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A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy

Background The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment has emerged as a novel strategy for studying renal diseases. Considering the numerous molecules involved in DN development, a high-throughput platform with parallel detection of multiple mRNAs is needed. In this study, we constructed a self...

Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells

Background Dyslipidemia and activation of renin-angiotensin system (RAS) contribute to the progression of chronic kidney disease (CKD). This study investigated possible synergistic effects of intrarenal RAS activation with hyperlipidemia in renal injuries. Methods Apolipoprotein knockout mice were fed with normal chow diet (control) or high fat diet (HF group) for eight weeks...

Associations of Serum 25-Hydroxyvitamin D3 Levels with Visceral Adipose Tissue in Chinese Men with Normal Glucose Tolerance

Objective Decreased serum vitamin D level is a common observation in obese adults. Since no Chinese population-based study has yet evaluated the relationship between serum vitamin D levels and the accurate adiposity variables, this study investigated the association of serum vitamin D (assessed by 25-hydroxyvitamin D3 [25(OH)D3]) levels with precise body fat content and...

Autophagy Limits Endotoxemic Acute Kidney Injury and Alters Renal Tubular Epithelial Cell Cytokine Expression

Sepsis related acute kidney injury (AKI) is a common in-hospital complication with a dismal prognosis. Our incomplete understanding of disease pathogenesis has prevented the identification of hypothesis-driven preventive or therapeutic interventions. Increasing evidence in ischemia-reperfusion and nephrotoxic mouse models of AKI support the theory that autophagy protects renal...

Combination Therapy with the Histone Deacetylase Inhibitor LBH589 and Radiation Is an Effective Regimen for Prostate Cancer Cells

Radiation therapy (RT) continues to be one of the most popular treatment options for localized prostate cancer (CaP). The purpose of the study was to investigate the in vitro effect of LBH589 alone and in combination with RT on the growth and survival of CaP cell lines and the possible mechanisms of radiosensitization of this combination therapy. The effect of LBH589 alone or in...

Dissecting microbial community structure and methane-producing pathways of a full-scale anaerobic reactor digesting activated sludge from wastewater treatment by metagenomic sequencing

Queensland ECR Project. Bing-Jie Ni acknowledges the support of Australian Research Council Discovery Early Career Researcher Award (DE130100451). 1. van Loosdrecht MCM , Brdjanovic D. Anticipating the next

Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer

Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer Jialan Zang,1–3,* Yong Hu,1,2,* Xiaoyue Xu,1,2 Jie Ni

Epithelial-to-mesenchymal transition correlates with gefitinib resistance in NSCLC cells and the liver X receptor ligand GW3965 reverses gefitinib resistance through inhibition of vimentin

,* Jialan Zang,2,* Xiaobing Qin,1 Dali Yan,1 Haixia Cao,1 Leilei Zhou,1 Jie Ni,1 Shaorong Yu,1 Jianzhong Wu,1 Ji-Feng Feng1 1Research Center for Clinical Oncology, Affiliated Cancer Hospital of Nanjing

Evaluation on the Nanoscale Zero Valent Iron Based Microbial Denitrification for Nitrate Removal from Groundwater

Acknowledgements This study was supported by the Australian Research Council (ARC) through Project DP130103147. Bing-Jie Ni acknowledges the support of ARC Discovery Early Career Researcher Award (DE130100451 ... for Xiaohu Dai in:Nature Research journals • PubMed • Google ScholarSearch for Bing-Jie Ni in:Nature Research journals • PubMed • Google Scholar Contributions L.P., Y.L. and B.-J.N. wrote the manuscript

Identification and Characterization of a Novel Non-Coding RNA Involved in Sperm Maturation

A long and ever-expanding roster of small (∼20–30 nucleotides) RNAs has emerged during the last decade, and most can be subsumed under the three main headings of microRNAs(miRNAs), Piwi-interacting RNAs(piRNAs), and short interferingRNAs(siRNAs). Among the three categories, miRNAs is the most quickly expanded group. The most recent number of identified miRNAs is 16,772 (Sanger...

Inflammation Disrupts the LDL Receptor Pathway and Accelerates the Progression of Vascular Calcification in ESRD Patients

Background Chronic inflammation plays a crucial role in the progression of vascular calcification (VC). This study was designed to investigate whether the low-density lipoprotein receptor (LDLr) pathway is involved in the progression of VC in patients with end-stage renal disease (ESRD) during inflammation. Methods and Results Twenty-eight ESRD patients were divided into control...

Model-Based Feasibility Assessment of Membrane Biofilm Reactor to Achieve Simultaneous Ammonium, Dissolved Methane, and Sulfide Removal from Anaerobic Digestion Liquor

Peng ZhiguoYuan Bing-Jie Ni OPEN In this study, the membrane biofilm reactor (MBfR) is proposed to achieve simultaneous removal of ammonium, dissolved methane, and sulfide from main-stream and side ... supported by the Australian Research Council (ARC) through Project DP130103147. Xueming Chen acknowledges the scholarship support from China Scholarship Council (CSC). Dr. Bing-Jie Ni acknowledges the support

Modeling of Nitrous Oxide Production from Nitritation Reactors Treating Real Anaerobic Digestion Liquor

Grant for Early Career Engineering Researcher (GE12015). Dr. Bing-Jie Ni acknowledges the support of ARC Discovery Early Career Researcher Award (DE130100451). Prof. Xiaodi Hao acknowledges the funding

Modelling Methane Production and Sulfate Reduction in Anaerobic Granular Sludge Reactor with Ethanol as Electron Donor

In this work, a mathematical model based on growth kinetics of microorganisms and substrates transportation through biofilms was developed to describe methane production and sulfate reduction with ethanol being a key electron donor. The model was calibrated and validated using experimental data from two case studies conducted in granule-based Upflow Anaerobic Sludge Blanket...

Nitric oxide synthase isoforms play distinct roles during acute peritonitis

Background. Acute peritonitis is the most frequent complication of peritoneal dialysis (PD). Increased nitric oxide (NO) release by NO synthase (NOS) isoforms has been implicated in acute peritonitis, but the role played by the NOS isoforms expressed in the peritoneum is unknown. Methods. We investigated the structural and functional consequences of acute peritonitis induced by...

Nitrous Oxide Production in Co- Versus Counter-Diffusion Nitrifying Biofilms

• Google ScholarSearch for Yiwen Liu in:Nature Research journals • PubMed • Google ScholarSearch for Xiaohu Dai in:Nature Research journals • PubMed • Google ScholarSearch for Bing-Jie Ni in:Nature Research ... reviewed the manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Bing-Jie Ni. Supplementary information Word documents1

Nitrous Oxide Production in a Granule-based Partial Nitritation Reactor: A Model-based Evaluation

Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorporated two N2O production pathways by ammonia-oxidizing bacteria...

Peri-implant conditions and marginal bone loss around cemented and screw-retained single implant crowns in posterior regions: A retrospective cohort study with up to 4 years follow-up

Table. STROBE checklist. (DOC) Author Contributions Conceptualization: Jie-Ni, Hong-Chang Lai. Data curation: Jie-Ni, Long-fei Zhuang. Formal analysis: Xiao-Meng Zhang, Lin-Feng Fan. Funding ... -Yu Shi. Writing ± review & editing: Jie-Ni. 9 / 11 10. 11. 12. 13. 14. 15. 16. 17. 18. Sherif S, Susarla HK, Kapos T, Munoz D, Chang BM, Wright RF. A systematic review of screw- versus cement

Progression of Cartilage Degradation, Bone Resorption and Pain in Rat Temporomandibular Joint Osteoarthritis Induced by Injection of Iodoacetate

Background Osteoarthritis (OA) is an important subtype of temporomandibular disorders. A simple and reproducible animal model that mimics the histopathologic changes, both in the cartilage and subchondral bone, and clinical symptoms of temporomandibular joint osteoarthritis (TMJOA) would help in our understanding of its process and underlying mechanism. Objective To explore...

Quantitative evaluation on the characteristics of activated sludge granules and flocs using a fuzzy entropy-based approach

Science & Technology of China, Hefei 230026, ChinaFang Fang, Bing-Jie Ni & Han-Qing Yu AuthorsSearch for Fang Fang in:Nature Research journals • PubMed • Google ScholarSearch for Li-Li Qiao in:Nature ... Research journals • PubMed • Google ScholarSearch for Bing-Jie Ni in:Nature Research journals • PubMed • Google ScholarSearch for Jia-Shun Cao in:Nature Research journals • PubMed • Google ScholarSearch for