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12 papers found.
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Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

Background Serum C-reactive protein (CRP), an acute inflammatory response biomarker, has been recognized as an indicator of malignant disease progression. However, the prognostic significance of CRP levels collected before tumor removal in intrahepatic cholangiocarcinoma requires further investigation. Methods We sampled the CRP levels in 140 patients with intrahepatic...

Positive expression of programmed death ligand-1 correlates with superior outcomes and might be a therapeutic target in primary pulmonary lymphoepithelioma-like carcinoma

,1,3,* Peng-fei Li,1,4,* Xin-ke Zhang,1,5 Jie-wei Chen,1,5 Hui-juan Qiu,1,2 Xiao-dong Wu,6 Bei Zhang1,21State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine

Overexpression of RNF2 Is an Independent Predictor of Outcome in Patients with Urothelial Carcinoma of the Bladder Undergoing Radical Cystectomy

Center, Guangzhou, ChinaXiang-Dong Li, Si-Liang Chen, Pei Dong, Jie-Wei Chen, Feng-Wei Wang, Sheng-Jie Guo, Li-Juan Jiang, Fang-Jian Zhou, Dan Xie & Zhuo-Wei LiuDepartment of Urology, Sun Yat-sen ... for Pei Dong in:Nature Research journals • PubMed • Google ScholarSearch for Jie-Wei Chen in:Nature Research journals • PubMed • Google ScholarSearch for Feng-Wei Wang in:Nature Research journals

The prognostic significance of tyrosine-protein phosphatase nonreceptor type 12 expression in nasopharyngeal carcinoma

and thank Miao Xu, Jie-Wei Chen, Feng Zhou, Yi-Hong Ling, and ChongMei Zhu for their comments on the key clinicopathological questions applied in this paper. All authors read and approved the final

Prognostic Significance of the pN Classification Supplemented by Vascular Invasion for Esophageal Squamous Cell Carcinoma

Background The biological behavior and clinical outcome of esophageal squamous cell carcinoma (ESCC) are difficult to predict. Methodology/Principal Findings We investigate the prognostic impact of vascular invasion to establish a risk stratification model to predict recurrence and overall survival. We retrospectively evaluated the vascular invasion of 433 patients with ESCC...

The prognostic effect of perineural invasion in esophageal squamous cell carcinoma

Background Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance in esophageal squamous cell carcinoma (ESCC) remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes. Methods We retrospectively evaluated the PNI of 433 patients with ESCC treated with...

Decreased Expression of PTPN12 Correlates with Tumor Recurrence and Poor Survival of Patients with Hepatocellular Carcinoma

Background Protein tyrosine phosphatase non-receptor type 12 (PTPN12), has been identified as a potent tumor suppressor in human cancers and a critical regulator of cell adhesion and migration. However, the PTPN12 expression and its prognostic significance in HCC have not been well elucidated. Methodology/Principal Findings In this study, tissue microarray-based...

Overexpression of ZEB2 in Peritumoral Liver Tissue Correlates with Favorable Survival after Curative Resection of Hepatocellular Carcinoma

Background ZEB2 has been suggested to mediate EMT and disease aggressiveness in several types of human cancers. However, the expression patterns of ZEB2 in hepatocellular carcinoma (HCC) and its effect on prognosis of HCC patients treated with hepatectomy are unclear. Methodology/Principal Findings In this study, the methods of tissue microarray and immunohistochemistry (IHC...

Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth

Jie-Wei Chen 0 Ying-Qin Li Ya-Fei Xu Xian-Yue Ren Ying Sun Hai-Qiang Mai Jian-Yong Shao Wei-Hua Jia Tie-Bang Kang Mu-Sheng Zeng Jun Ma 0 Equal contributors Sun Yat-sen University Cancer Center; State

Increased Intratumoral Neutrophil in Colorectal Carcinomas Correlates Closely with Malignant Phenotype and Predicts Patients' Adverse Prognosis

Background Substantial evidence suggests that the presence of inflammatory cells plays a critical role in the development and/or progression of human tumors. Neutrophils are the common inflammatory cells in tumors; however, the infiltration of intratumoral neutrophils in colorectal carcinoma (CRC) and its effect on CRC patients' prognosis are poorly understood. Methodology...

High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

Background It has been suggested that p300 participates in the regulation of a wide range of cell biological processes and mutation of p300 has been identified in certain types of human cancers. However, the expression dynamics of p300 in hepatocellular carcinoma (HCC) and its clinical/prognostic significance are unclear. Methods In this study, the methods of reverse...

Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis

Background The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significance of Rab27B in BC patients. Methods The mRNA/protein expression level of Rab27B was examined by performing Real-time PCR, western blot, and immunohistochemistry...