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Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis

metastasis. KeywordsHepatocellular carcinoma CD147 Phosphorylation Invasion Metastasis  Jin Jin and Shi-Jie Wang contributed equally to this work. Electronic supplementary material The online version of

Analytical equation for outflow along the flow in a perforated fluid distribution pipe

curation: Quanli Zong. Formal analysis: Huanfang Liu, Quanli Zong. Funding acquisition: Huanfang Liu. Investigation: Huanfang Liu, Quanli Zong, Jin Jin. Methodology: Huanfang Liu. Project administration ... : Hongxing Lv. Software: Jin Jin. Supervision: Hongxing Lv. Validation: Huanfang Liu, Quanli Zong. Visualization: Jin Jin. Writing ± original draft: Huanfang Liu, Quanli Zong. Writing ± review & editing

Effect of plating temperature on electroless amorphous Ni–P film on Si wafers in an alkaline bath solution

Nickel–phosphorus (Ni–P) film was deposited by electroless process on the surface of p-type polycrystalline silicon at the temperature of 60–80 °C and pH value of 10.0. The effect of plating temperature on morphology, crystallographic structure, chemical composition and deposition rate of Ni–P film was studied. Microstructure and morphology of surface and cross section of the...

Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling Pathway

Kwon, Miyeon Kim, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hye Jin Jin, and Hong Bae Jeon Biomedical Research Institute, MEDIPOST Co. Ltd., Seongnam 13494, Republic of Korea Correspondence ... should be addressed to Hye Jin Jin; rk.oc.tsop-idem@77ynneg and Hong Bae Jeon; rk.oc.tsop-idem@bhj Received 11 January 2018; Accepted 3 May 2018; Published 11 July 2018 Academic Editor: Jonathan Marchant

Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling Pathway

Kwon, Miyeon Kim, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hye Jin Jin, and Hong Bae Jeon Biomedical Research Institute, MEDIPOST Co. Ltd., Seongnam 13494, Republic of Korea Correspondence ... should be addressed to Hye Jin Jin; rk.oc.tsop-idem@77ynneg and Hong Bae Jeon; rk.oc.tsop-idem@bhj Received 11 January 2018; Accepted 3 May 2018; Published 11 July 2018 Academic Editor: Jonathan Marchant

Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

the manuscript. All authors read and approved the final manuscript. Author information Author notes These authors contributed equally: Bo Jing, Jin Jin. AffiliationsKey Laboratory of Cell ... Institute of Medicine, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, ChinaBo Jing, Jin Jin, Meng Liu, Li Yang, Hu Lei, Hanzhang Xu, Jiong Deng & Yingli WuDepartment of Hematology, Rui

Cauchy Noise Removal by Nonconvex ADMM with Convergence Guarantees

Image restoration is one of the essential tasks in image processing. In order to restore images from blurs and noise while also preserving their edges, one often applies total variation (TV) minimization. Cauchy noise, which frequently appears in engineering applications, is a kind of impulsive and non-Gaussian noise. Removing Cauchy noise can be achieved by solving a nonconvex...

Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up

Background Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated. Methods A retrospective study of sixteen patients was undertaken to evaluate treatment of tumors with joint arthroplasty and tumor resection. The...

Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells

Background Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical use, and improved culture systems are required. Here, we report the effects of calcium (Ca2+) and hypoxia on the proliferation of human umbilical cord blood...

Exposure–Response and Tumor Growth Inhibition Analyses of the Monovalent Anti-c-MET Antibody Onartuzumab (MetMAb) in the Second- and Third-Line Non-Small Cell Lung Cancer

onartuzumab dose in this population. ACKNOWLEDGMENTS We acknowledge Bert Lum from Genentech Inc. for his expert review and comments. COMPLIANCE WITH ETHICAL STANDARDS Conflict of Interest Kelong Han, Jin ... Jin, Helen Winter, and Mark Stroh receive salary from Genentech and hold stocks in Roche Pharmaceuticals. In addition, Jin Jin also holds stock in Eli Lilly. Fredrik Jonsson, Pascal Chanu, and René

Identification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkin's lymphoma

Despite great advancements in the treatment of non-Hodgkin lymphoma (NHL), sensitivity of different subtypes to therapy varies. Targeting the aberrant activation NF-κB signaling pathways in lymphoid malignancies is a promising strategy. Here, we report that 11(13)-dehydroivaxillin (DHI), a natural compound isolated from the Carpesium genus, induces growth inhibition and apoptosis...

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

. Competing interest Kelong Han, Alan Sandler, Asha Das, and Jin Jin are employees of Genentech and hold stocks of Roche Pharmaceuticals; In addition, Jin Jin also holds stocks in Eli Lilly; Laurent Claret and

Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow

Appropriate bone mass is maintained by bone-forming osteoblast and bone-resorbing osteoclasts. Mesenchymal stem cell (MSC) lineage cells control osteoclastogenesis via expression of RANKL and OPG (receptor activator of nuclear factor κB ligand and osteoprotegerin), which promote and inhibit bone resorption, respectively. Protein crosslinking enzymes transglutaminase 2 (TG2) and...

Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

Zhou & Jin Jin AuthorsSearch for Zhengjun Gao in:Nature Research journals • PubMed • Google Scholar Search for Yiyuan Li in:Nature Research journals • PubMed • Google Scholar Search for Fei Wang ... Scholar Search for Ji-Yong Zhou in:Nature Research journals • PubMed • Google Scholar Search for Xin-Hua Feng in:Nature Research journals • PubMed • Google Scholar Search for Jin Jin in:Nature Research

Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is characterized by uncontrolled secretion of autoantibodies by plasma cells. Although the functional importance of plasma cells and autoantibodies in SLE has been well established, the underlying molecular mechanisms of controlling autoantibody production remain poorly understood. Here we show that Peli1 has a B cell-intrinsic function to...

Bufei Huoxue Capsule Attenuates PM2.5-Induced Pulmonary Inflammation in Mice

Qin, Mingjie Gu, and Jin Jin also contributed equally to this work. References Q. Zhao, K.-B. He, Y.-L. Ma et al., “Regional PM pollution in Beijing and surrounding area during summertime,” Huan

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

, Pengfei Fang, Junling Jia, Jin Jin, Sheng Ye & Long ZhangInstitutes of Biology and Medical Science, Soochow University, 215123, Suzhou, ChinaFeng Xie & Fangfang ZhouState Key Laboratory for Diagnostic and ... Search for Jin Jin in:Nature Research journals • PubMed • Google Scholar Search for Chen Ding in:Nature Research journals • PubMed • Google Scholar Search for Sheng Ye in:Nature Research journals