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Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation

in:Nature Research journals • PubMed • Google ScholarSearch for Jin-Sook Jeong in:Nature Research journals • PubMed • Google ScholarSearch for Seong-Wook Lee in:Nature Research journals • PubMed • Google ... authors declare no competing financial interests. Corresponding authors Correspondence to Jin-Sook Jeong or Seong-Wook Lee. Supplementary information Word documents1.Supplementary Information

Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF

Background We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis.

Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme

A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in vivo function of the hTERT-targeting trans-splicing ribozymes by employing the molecular analysis of expression level of genes affected by the ribozyme delivery into...

A Case of Hepatic Angiomyolipoma Which Was Misdiagnosed as Hepatocellular Carcinoma in a Hepatitis B Carrier

Bae,1 Jin Han Cho,2 Hee Jin Kwon,2 Jin Sook Jeong,3 Young Hoon Roh,4 and Sang Young Han1 1Department of Internal Medicine, Dong-A University College of Medicine, Busan 602-715, Republic of Korea

A Case of Hepatic Angiomyolipoma Which Was Misdiagnosed as Hepatocellular Carcinoma in a Hepatitis B Carrier

Bae,1 Jin Han Cho,2 Hee Jin Kwon,2 Jin Sook Jeong,3 Young Hoon Roh,4 and Sang Young Han1 1Department of Internal Medicine, Dong-A University College of Medicine, Busan 602-715, Republic of Korea

A Case of Hepatic Angiomyolipoma Which Was Misdiagnosed as Hepatocellular Carcinoma in a Hepatitis B Carrier

Bae,1 Jin Han Cho,2 Hee Jin Kwon,2 Jin Sook Jeong,3 Young Hoon Roh,4 and Sang Young Han1 1Department of Internal Medicine, Dong-A University College of Medicine, Busan 602-715, Republic of Korea

Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

Background Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative...

Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway

Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer of extracellular signals. Two pathways were studied. One was the G α s mediated cAMP pathway where two signal molecules were yielded, including RII and protein kinase A. The other was the G α q...

Vascular administration of adenoviral vector soaked in absorbable gelatin sponge particles (GSP) prolongs the transgene expression in hepatocytes

• PubMed • Google ScholarSearch for Jin-Sook Jeong in:Nature Research journals • PubMed • Google ScholarSearch for Seo-Hee Rha in:Nature Research journals • PubMed • Google ScholarSearch for Seung-Eun Kim

Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line

Hydroxyurea is commonly used to treat hematologic disorders and some type of solid tumors, but the mechanism for its therapeutic effect is not clearly known. In this study, we examined the effect of hydroxyurea on rat hepatoma McA-RH7777 cells, specifically, on the role of mitogen-activated protein (MAP) kinase signal transduction pathways and p21Waf1, p27Kip1 and p53. Rat...

Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver

Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of cell cycle regulators after G1 progression in the same repetitive low dose TA treated hepatocytes system and to define the determinators involved in G2 arrest. TA was daily administered...