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6 papers found.
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Association of RIP2 gene polymorphisms and systemic lupus erythematosus in a Chinese population

The aim of this study was to investigate the association of receptor interacting protein 2 (RIP2) single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. A case–control study was performed on the SNPs rs16900617 and rs16900627 in 590 Chinese SLE patients and 660 healthy controls. These SNPs were typed by TaqMan...

Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune diseases, which affects multiple organ systems such as kidney. The imbalance of T-helper 1 (Th1)/Th2 cells is critical in the pathogenesis of SLE. The T-cell immunoglobulin mucin (TIM) proteins comprise a family of cell surface molecules expressed on T cells that regulate Th1- and Th2-cell-mediated immunity...

Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis

& Major Disease Screening and Diagnosis, Anhui Medical University for the provision of experimental equipment and technical supports. Author Contributions Conceptualization: Jin-Hui Tao. Data curation ... : Jin-Hui Tao, Jiang-Ping Tang, Yong Zhang, Qin Liu, Ya-Ling Wang. Formal analysis: Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang. Funding acquisition: Jin-Hui Tao. Investigation: Jin-Hui Tao, Xiao-Juan Dai

Single nucleotide polymorphisms of HSP90AA1 gene influence response of SLE patients to glucocorticoids treatment

Heat shock protein 90 (HSP90) is an important glucocorticoid receptor (GR) chaperone protein, and is supposed to be the key factor in regulating glucocorticoids (GCs) effects. The aim of the present study was to explore whether single nucleotide polymorphisms (SNPs) within HSP90AA1 gene affect the response of systemic lupus erythematosus (SLE) patients to GCs treatment. Two...