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6 papers found.
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Comparative analysis of the human saliva microbiome from different climate zones: Alaska, Germany, and Africa

the late Ivane Nasidze for valuable contributions to this work. This research was funded by the Max Planck Society and the National Science Foundation (OPP-0732857). Jing Li was supported by the

Global analysis of saliva as a source of bacterial genes for insights into human population structure and migration studies

Background The genetic diversity of the human microbiome holds great potential for shedding light on the history of our ancestors. Helicobacter pylori is the most prominent example as its analysis allowed a fine-scale resolution of past migration patterns including some that could not be distinguished using human genetic markers. However studies of H. pylori require stomach...

The saliva microbiome of Pan and Homo

Background It is increasingly recognized that the bacteria that live in and on the human body (the microbiome) can play an important role in health and disease. The composition of the microbiome is potentially influenced by both internal factors (such as phylogeny and host physiology) and external factors (such as diet and local environment), and interspecific comparisons can aid...

Identification of gene fusions from human lung cancer mass spectrometry data

Background Tandem mass spectrometry (MS/MS) technology has been applied to identify proteins, as an ultimate approach to confirm the original genome annotation. To be able to identify gene fusion proteins, a special database containing peptides that cross over gene fusion breakpoints is needed. Methods It is impractical to construct a database that includes all possible fusion...

Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach

Despite the many potential advantages of Ad vectors for vaccine application, the full utility of current Ad vaccines may be limited by the host anti-vector immune response. Direct incorporation of antigens into the adenovirus capsid offers a new and exciting approach for vaccination strategies; this strategy exploits the inherent antigenicity of the Ad vector. Critical to...