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Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

notes These authors contributed equally: Jie Song, Jing Li, Fangji Yang AffiliationsDepartment of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaJie Song ... Haematology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, ChinaDongjun Lin AuthorsSearch for Jie Song in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature

Loss of miR-144 signaling interrupts extracellular matrix remodeling after myocardial infarction leading to worsened cardiac function

We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending coronary artery in male miR-144 KO mice, and wild-type littermates...

Bacterial diversity among the fruit bodies of ectomycorrhizal and saprophytic fungi and their corresponding hyphosphere soils

, Nanjing, 210023, ChinaYaping Liu, Qibiao Sun, Jing Li & Bin Lian AuthorsSearch for Yaping Liu in:Nature Research journals • PubMed • Google Scholar Search for Qibiao Sun in:Nature Research journals ... • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search for Bin Lian in:Nature Research journals • PubMed • Google Scholar Contributions B.L. designed

Repurposing CRISPR-Cas12b for mammalian genome engineering

The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cleavage activity at endogenous genome remains to be explored...

NIPS, a 3D network-integrated predictor of deleterious protein SAPs, and its application in cancer prognosis

computations. Author information AffiliationsDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaBo Wang, Jing Li, Xi Cheng ... , Qiao Zhou, Jingxu Yang, Menghuan Zhang, Haifeng Chen & Jing Li AuthorsSearch for Bo Wang in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed

Size-dependent kinetics during non-equilibrium lithiation of nano-sized zinc ferrite

Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of spinel ZnFe2O4 as a function of particle size. We have found...

Meta-analysis of soil mercury accumulation by vegetables

Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentration factor (BCF) include cowpea, long bean, and radish, whereas...

Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc

, Guangzhou, 510515, ChinaJun-Wen Shi, Ting-Ting Zhang, Jie Yang, Xiao-Lin Lin, Jun-Shuang Jia, Hong-Fen Shen, Sheng-Chun Wang, Jing Li, Wen-Tao Zhao & Dong XiaoInstitute of Comparative Medicine & Laboratory ... Research journals • PubMed • Google Scholar Search for Sheng-Chun Wang in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search

Phase-field model of pitting corrosion kinetics in metallic materials

in:Nature Research journals • PubMed • Google Scholar Search for Jing-Li Luo in:Nature Research journals • PubMed • Google Scholar Search for San-Qiang Shi in:Nature Research journals • PubMed • Google

Molecular characterization of mesenchymal stem cells in human osteoarthritis cartilage reveals contribution to the OA phenotype

: Collection and assembly of data, final approval of manuscript. Jing Li: Collection and assembly of data, final approval of manuscript. Nicholas Lemme: Collection of data, final approval of manuscript. Richard

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are...

Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4

Macau, Macau, People’s Republic of ChinaLi Wang, Jing-jing Li, Peipei Li, Zhiqiang Zhao & Li-jun DiDepartment of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, 230032, ChinaLi-yu Guo ...  & Haisheng Zhou AuthorsSearch for Li Wang in:Nature Research journals • PubMed • Google Scholar Search for Jing-jing Li in:Nature Research journals • PubMed • Google Scholar Search for Li-yu Guo in:Nature

Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1

MicroRNAs (miRNAs) are small noncoding RNA molecules that play important roles in various biological processes. Much evidence shows that miRNAs are closely associated with numerous virus infections; however, involvement of cellular miRNAs in influenza A virus (IAV) infection is unclear. Here, we found that expression of miR-203 was up-regulated markedly via two different...

The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis

The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 atherothrombotic stroke, 94 hemorrhagic stroke and 225 lacunar infraction) and 616...

Analysis of the genotype-phenotype correlation in patients with phenylketonuria in mainland China

University (grant ID: IRT0935). Author information Author notes Nana Li, Chunhua He and Jing Li contributed equally to this work. AffiliationsNational Center for Birth Defect Monitoring, West China Second ... journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search for Jing Tao in:Nature Research journals • PubMed • Google Scholar Search for Zhen Liu

Dual-electrochromic bipolar electrode-based universal platform for the construction of various visual advanced logic devices

A universal logic platform based on dual-electrochromic bipolar electrodes (BPEs) for the operation of various visual advanced logic devices was designed and constructed for the first time. Two BPEs separated by three reaction channels filled with different reaction solutions constituted the closed BPE system and were used as the initial state. Under different input combinations...

Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

Scientific RepoRts | through downregulation of PI3K? mediated PI3K/AKT/mTOR/p70S6K/ Hong-Wei Zhang Jin-Jiao Hu Ruo-Qiu Fu Xin Liu Yan-Hao Zhang Jing Li Lei Liu Yu-Nong Li Qin Deng Qing-Song Luo Qin

Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance

Research journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search for Lei Gao in:Nature Research journals • PubMed • Google Scholar Search for Dai