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A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71

Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. We report a rare case of HFMD in a 16-year-old male...

Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

notes These authors contributed equally: Jie Song, Jing Li, Fangji Yang AffiliationsDepartment of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaJie Song ... Haematology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, ChinaDongjun Lin AuthorsSearch for Jie Song in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature

Detection and analysis of CpG sites with multimodal DNA methylation level distributions and their relationships with SNPs

DNA methylation levels at cytosine-phosphate-guanine (CpG) sites with multimodal distributions among different samples have been reported recently. One possible explanation for such variability is that genetic variants might affect epigenetic variation. One obvious case is that mutations such as single-nucleotide polymorphisms (SNPs) interrupt CpG sites, resulting in different...

The needs of informal caregivers and barriers of primary care workers toward dementia management in primary care: a qualitative study in Beijing

Informal caregivers of people with dementia in Beijing are increasingly called upon to provide home-based care for their patients due to the increasing number of dementia patients and the shortage of standardized institutional solutions of care for patients in China. This study aimed to clarify the needs of informal caregivers and barriers of primary care workers toward dementia...

Global transcriptome analysis of H5N1 influenza virus-infected human cells

BackgroundInfluenza A virus (IAV) belongs to the Orthomyxoviridae family. IAV causes a highly contagious respiratory disease in humans that exacts severe economic losses globally. The virus uses strategies developed to exploit and subvert cellular proteins and pathways to increase its own replication and to inhibit antiviral immune response.ResultsA/bar-headed goose/Qinghai/1...

A nomogram for predicting the HER2 status in female patients with breast cancer in China: a nationwide, multicenter, 10-year epidemiological study

The concordance rate of human epidermal growth factor receptor 2 (HER2) status between core needle biopsy (CNB) and subsequent excisional biopsies of the same tumor varies from 81 to 96%, which may cause inappropriate neoadjuvant therapy that impair the potential benefit from HER2 targeted therapy for patients. This study aimed to establish a nomogram to predict the HER2 status...

Loss of miR-144 signaling interrupts extracellular matrix remodeling after myocardial infarction leading to worsened cardiac function

We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending coronary artery in male miR-144 KO mice, and wild-type littermates...

Bacterial diversity among the fruit bodies of ectomycorrhizal and saprophytic fungi and their corresponding hyphosphere soils

, Nanjing, 210023, ChinaYaping Liu, Qibiao Sun, Jing Li & Bin Lian AuthorsSearch for Yaping Liu in:Nature Research journals • PubMed • Google Scholar Search for Qibiao Sun in:Nature Research journals ... • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search for Bin Lian in:Nature Research journals • PubMed • Google Scholar Contributions B.L. designed

Characterization of molecular diversity and genome-wide association study of stripe rust resistance at the adult plant stage in Northern Chinese wheat landraces

Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe rust is the most cost-effective method to control the disease. In the present study, a genome-wide association study (GWAS) was conducted to identify...

Rat limbal niche cells can induce transdifferentiation of oral mucosal epithelial cells into corneal epithelial-like cells in vitro

BackgroundCultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal microenvironment, limbal niche cells (LNCs) play a key role in the direction of stem cell differentiation. In this study, we investigated whether LNCs can induce...

Rat limbal niche cells can induce transdifferentiation of oral mucosal epithelial cells into corneal epithelial-like cells in vitro

Cultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal microenvironment, limbal niche cells (LNCs) play a key role in the direction of stem cell differentiation. In this study, we investigated whether LNCs can induce the...

NIPS, a 3D network-integrated predictor of deleterious protein SAPs, and its application in cancer prognosis

computations. Author information AffiliationsDepartment of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaBo Wang, Jing Li, Xi Cheng ... , Qiao Zhou, Jingxu Yang, Menghuan Zhang, Haifeng Chen & Jing Li AuthorsSearch for Bo Wang in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed

Repurposing CRISPR-Cas12b for mammalian genome engineering

The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cleavage activity at endogenous genome remains to be explored...

Size-dependent kinetics during non-equilibrium lithiation of nano-sized zinc ferrite

Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of spinel ZnFe2O4 as a function of particle size. We have found...

Meta-analysis of soil mercury accumulation by vegetables

Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentration factor (BCF) include cowpea, long bean, and radish, whereas...

A colorimetric assay to rapidly determine the activities of lytic polysaccharide monooxygenases

Lytic polysaccharide monooxygenase (LPMOs) are enzymes that catalyze the breakdown of polysaccharides in biomass and have excellent potential for biorefinery applications. However, their activities are relatively low, and methods to measure these activities are costly, tedious or often reflect only an apparent activity to the polysaccharide substrates. Here, we describe a new...

Phase-field model of pitting corrosion kinetics in metallic materials

in:Nature Research journals • PubMed • Google Scholar Search for Jing-Li Luo in:Nature Research journals • PubMed • Google Scholar Search for San-Qiang Shi in:Nature Research journals • PubMed • Google

Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc

, Guangzhou, 510515, ChinaJun-Wen Shi, Ting-Ting Zhang, Jie Yang, Xiao-Lin Lin, Jun-Shuang Jia, Hong-Fen Shen, Sheng-Chun Wang, Jing Li, Wen-Tao Zhao & Dong XiaoInstitute of Comparative Medicine & Laboratory ... Research journals • PubMed • Google Scholar Search for Sheng-Chun Wang in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature Research journals • PubMed • Google Scholar Search

The effects of patients initiated aggression on Chinese medical students’ career planning

Patient initiated aggression is common among Chinese health-care workers, reaching over 10,000 incidents annually (Jinyang web. http://6d.dxy.cn/article/55497 . 2013), and the tense doctor-patient relationship generates stress among medical students. Because of the paucity of data (few surveys pay attention to the effects of violence perpetrated by patients on medical students...

The clinical spectrum and genetic variability of limb-girdle muscular dystrophy in a cohort of Chinese patients

Limb-girdle muscular dystrophy (LGMD) is a commonly diagnosed hereditary muscular disorder, characterized by the progressive weakness of the limb-girdle muscles. Although the condition has been well-characterized, clinical and genetic heterogeneity can be observed in patients with LGMD. Here, we aimed to describe the clinical manifestations and genetic variability among a cohort...