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Interpreting genomic data via entropic dissection

369 8656; Email: Correspondence may also be addressed to Jing Li. Tel: +1 216 368 0356; Email: feasible by the development of efficient sampling techniques, namely, the Markov Chain Monte Carlo (MCMC

Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq

Rhesus macaque is a widely used primate model organism. Its genome annotations are however still largely comparative computational predictions derived mainly from human genes, which precludes studies on the macaque-specific genes, gene isoforms or their regulations. Here we took advantage of histone H3 lysine 4 trimethylation (H3K4me3)’s ability to mark transcription start sites...

Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

The structure of human telomere DNA is of intense interest because of its role in the biology of both cancer and aging. The sequence [5′-AGGG(TTAGGG)3] has been used as a model for telomere DNA in both NMR and X-ray crystallographic studies, the results of which show dramatically different structures. In Na+ solution, NMR revealed an antiparallel G-quadruplex structure that...