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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells

’ Contributions Yong Li performed the experiments and wrote the manuscript; Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, and Xiao-bin Cui performed some of the experiments; Yong Li, Ping

miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells

’ Contributions Yong Li performed the experiments and wrote the manuscript; Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, and Xiao-bin Cui performed some of the experiments; Yong Li, Ping

miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells

Wang, Jing Li, and Xiao-bin Cui performed some of the experiments; Yong Li, Ping Gong, Ji-xue Hou, and Na Li analyzed the data; Na Li designed and supervised the study, wrote and edited the manuscript

CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction

University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong Received 8 July 2016; Revised 13 October 2016; Accepted 18 October 2016 Academic Editor: Ghislain Opdenakker Copyright © 2016 Jing Li

CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction

University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong Received 8 July 2016; Revised 13 October 2016; Accepted 18 October 2016 Academic Editor: Ghislain Opdenakker Copyright © 2016 Jing Li

Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8

 Rudra Copyright © 2016 Jing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any ... . Authors’ Contributions Jing Li and Lanzhu Yue contributed equally to the manuscript. Acknowledgments This work was supported by the National Natural Science Foundation of China (81170472 and 81400085

Th17 Cells Exhibit Antitumor Effects in MDS Possibly through Augmenting Functions of CD8

 Rudra Copyright © 2016 Jing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any ... . Authors’ Contributions Jing Li and Lanzhu Yue contributed equally to the manuscript. Acknowledgments This work was supported by the National Natural Science Foundation of China (81170472 and 81400085

qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data

In an isogenic cell population, phenotypic heterogeneity among individual cells is common and critical for survival of the population under different environment conditions. DNA modification is an important epigenetic factor that can regulate phenotypic heterogeneity. The single molecule real-time (SMRT) sequencing technology provides a unique platform for detecting a wide range...

Chemokines in Chronic Liver Allograft Dysfunction Pathogenesis and Potential Therapeutic Targets

Despite advances in immunosuppressive drugs, long-term success of liver transplantation is still limited by the development of chronic liver allograft dysfunction. Although the exact pathogenesis of chronic liver allograft dysfunction remains to be established, there is strong evidence that chemokines are involved in organ damage induced by inflammatory and immune responses after...

Chemokines in Chronic Liver Allograft Dysfunction Pathogenesis and Potential Therapeutic Targets

Despite advances in immunosuppressive drugs, long-term success of liver transplantation is still limited by the development of chronic liver allograft dysfunction. Although the exact pathogenesis of chronic liver allograft dysfunction remains to be established, there is strong evidence that chemokines are involved in organ damage induced by inflammatory and immune responses after...

Chemokines in Chronic Liver Allograft Dysfunction Pathogenesis and Potential Therapeutic Targets

Despite advances in immunosuppressive drugs, long-term success of liver transplantation is still limited by the development of chronic liver allograft dysfunction. Although the exact pathogenesis of chronic liver allograft dysfunction remains to be established, there is strong evidence that chemokines are involved in organ damage induced by inflammatory and immune responses after...

Interpreting genomic data via entropic dissection

369 8656; Email: Correspondence may also be addressed to Jing Li. Tel: +1 216 368 0356; Email: feasible by the development of efficient sampling techniques, namely, the Markov Chain Monte Carlo (MCMC

RecJ-like protein from Pyrococcus furiosus has 3′–5′ exonuclease activity on RNA: implications for proofreading of 3′-mismatched RNA primers in DNA replication

Replicative DNA polymerases require an RNA primer for leading and lagging strand DNA synthesis, and primase is responsible for the de novo synthesis of this RNA primer. However, the archaeal primase from Pyrococcus furiosus (Pfu) frequently incorporates mismatched nucleoside monophosphate, which stops RNA synthesis. Pfu DNA polymerase (PolB) cannot elongate the resulting 3...

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

MDC1 is a key mediator of the DNA-damage response in mammals with several phosphorylation-dependent protein interaction domains. The function of its N-terminal forkhead-associated (FHA) domain remains elusive. Here, we show with structural, biochemical and cellular data that the FHA domain mediates phosphorylation-dependent dimerization of MDC1 in response to DNA damage. Crystal...

Chinese SLE Treatment and Research Group Registry: III. Association of Autoantibodies with Clinical Manifestations in Chinese Patients with Systemic Lupus Erythematosus

March 2014; Published 23 April 2014 Academic Editor: Marvin J. Fritzler Copyright © 2014 Jing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which ... . Authors’ Contribution Jing Li, Xiaomei Leng, and Zhijun Li contributed equally to this study. All authors made substantial contributions to conception and design. Dr. Jing Li, Dr. Xiaomei Leng, and Dr

Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways

Various ‘omics’ technologies, including microarrays and gas chromatography mass spectrometry, can be used to identify hundreds of interesting genes, proteins and metabolites, such as differential genes, proteins and metabolites associated with diseases. Identifying metabolic pathways has become an invaluable aid to understanding the genes and metabolites associated with studying...

Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq

Rhesus macaque is a widely used primate model organism. Its genome annotations are however still largely comparative computational predictions derived mainly from human genes, which precludes studies on the macaque-specific genes, gene isoforms or their regulations. Here we took advantage of histone H3 lysine 4 trimethylation (H3K4me3)’s ability to mark transcription start sites...

dbDEPC 2.0: updated database of differentially expressed proteins in human cancers

A large amount of differentially expressed proteins (DEPs) have been identified in various cancer proteomics experiments, curation and annotation of these proteins are important in deciphering their roles in oncogenesis and tumor progression, and may further help to discover potential protein biomarkers for clinical applications. In 2009, we published the first database of DEPs...

SubpathwayMiner: a software package for flexible identification of pathways

With the development of high-throughput experimental techniques such as microarray, mass spectrometry and large-scale mutagenesis, there is an increasing need to automatically annotate gene sets and identify the involved pathways. Although many pathway analysis tools are developed, new tools are still needed to meet the requirements for flexible or advanced analysis purpose. Here...

Thermal difference spectra: a specific signature for nucleic acid structures

We show that nucleic acid structures may be conveniently and inexpensively characterized by their UV thermal difference spectra. A thermal difference spectrum (TDS) is obtained for a nucleic acid by simply recording the ultraviolet absorbance spectra of the unfolded and folded states at temperatures above and below its melting temperature (Tm). The difference between these two...