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Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients

Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2

Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice

Hospital, Beijing, ChinaYaqi Yin, Yu Cheng, Li Zang, Jieqing Gao, Jing Xue & Yiming MuDepartment of Molecular Biology, Institute of Basic Medicine, School of Life Science, Chinese PLA General Hospital ... Scholar Search for Jieqing Gao in:Nature Research journals • PubMed • Google Scholar Search for Jing Xue in:Nature Research journals • PubMed • Google Scholar Search for Zongyan Xie in:Nature Research

Development and characterization of a polarized human endometrial cell epithelia in an air–liquid interface state

Human endometrial epithelia undergo injury repair and regeneration with the menstrual cycle; however, mechanisms underpinning the roles of endometrial epithelial cells in endometrial lesions and regeneration remain incompletely understood, mainly owing to the difficulty in the isolation and expansion of primary endometrial epithelial cells and the lack of reliable models for in...

Recent advances in synthetic methods and applications of silver nanostructures

As the advanced functional materials, silver nanoparticles are potentially useful in various fields such as photoelectric, bio-sensing, catalysis, antibacterial and other fields, which are mainly based on their various properties. However, the properties of silver nanoparticles are usually determined by their size, shape, and surrounding medium, which can be modulated by various...

Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial

Luo and Jing Xue are co-first authors Background: The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to

Use of an Improved Matching Algorithm to Select Scaffolds for Enzyme Design Based on a Complex Active Site Model

Active site preorganization helps native enzymes electrostatically stabilize the transition state better than the ground state for their primary substrates and achieve significant rate enhancement. In this report, we hypothesize that a complex active site model for active site preorganization modeling should help to create preorganized active site design and afford higher...

Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations

Background Environmental perturbation of epigenetic mechanisms is linked to a growing number of diseases. Characterizing the role environmental factors play in modifying the epigenome is important for disease etiology. Vitamin D is an essential nutrient affecting brain, bone, heart, immune and reproductive health. Vitamin D insufficiency is a global issue, and the role in...

Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis

Copyright © 2017 Jing Xue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... .Competing Interests The authors declare that they have no competing interests. Authors’ Contributions Shuhong Chi and Xiaoming Liu conceived and designed the experiments; Jing Xue and Jiali Yang analyzed the

Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis

Copyright © 2017 Jing Xue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... .Competing Interests The authors declare that they have no competing interests. Authors’ Contributions Shuhong Chi and Xiaoming Liu conceived and designed the experiments; Jing Xue and Jiali Yang analyzed the

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly

The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise mechanism of clathrin assembly is not yet known. Clathrin assembly protein AP180 has more clathrin binding motifs than any other endocytic protein and has a major role in the assembly of the clathrin coat...

Segmentation of Hyperacute Cerebral Infarcts Based on Sparse Representation of Diffusion Weighted Imaging

Segmentation of infarcts at hyperacute stage is challenging as they exhibit substantial variability which may even be hard for experts to delineate manually. In this paper, a sparse representation based classification method is explored. For each patient, four volumetric data items including three volumes of diffusion weighted imaging and a computed asymmetry map are employed to...

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Interests The authors declare that they have no competing interests. Authors’ Contributions Juan Shi, Shuhong Chi, Jing Xue, and Jiali Yang collected references and wrote the draft; Jiali Yang and Feng Li

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Interests The authors declare that they have no competing interests. Authors’ Contributions Juan Shi, Shuhong Chi, Jing Xue, and Jiali Yang collected references and wrote the draft; Jiali Yang and Feng Li

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Interests The authors declare that they have no competing interests. Authors’ Contributions Juan Shi, Shuhong Chi, Jing Xue, and Jiali Yang collected references and wrote the draft; Jiali Yang and Feng Li

Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer

,1,2 Dali Yan,1,2 Siwen Liu,4 Jieyu He,5 Jing Xue,4 Jianzhong Wu,4 Jifeng Feng2 1The Fourth Clinical School of Nanjing Medical University, 2Department of Chemotherapy, Nanjing Medical University

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation. In this study, we examined whether cGAS plays a role in RA FLS. In this study, cGAS was overexpressed in RA-FLS compared with OA FLS...

Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway

’ Contributions Jinxi He and Xiaoming Liu conceived and designed the experiments; Jiali Yang, Kangjian Zhang, and Jun Wei analyzed the data and drafted the manuscript; Jiali Yang, Kangjian Zhang, Jing Xue, Jun Wei

Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway

’ Contributions Jinxi He and Xiaoming Liu conceived and designed the experiments; Jiali Yang, Kangjian Zhang, and Jun Wei analyzed the data and drafted the manuscript; Jiali Yang, Kangjian Zhang, Jing Xue, Jun Wei

Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress

The present study was aimed at investigating the effect of amifostine on myocardial ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert-butyl hydroperoxide). The results showed that pretreatment with amifostine significantly attenuated cell apoptosis and death, accompanied by decreased reactive oxygen species (ROS) production and lower mitochondrial...

The ∼16 kDa C-Terminal Sequence of Clathrin Assembly Protein AP180 Is Essential for Efficient Clathrin Binding

Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro. Both AP180 and its ubiquitously expressed homolog clathrin assembly lymphoid myeloid leukemia protein (CALM) control vesicle size and shape in clathrin mediated endocytosis. The clathrin assembly role of AP180 is...