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Deletion of exons 17 and 18 in prestin’s STAS domain results in loss of function

Cochlear outer hair cells (OHC) express the motor protein, prestin, which is required for sensitivity and frequency selectivity. Because our previous work showed that a calmodulin binding site (CBS) was located in prestin’s C-terminal, specifically within the intrinsically disordered region, we sought to delete the IDR to study the functional significance of calcium-dependent...

A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens

Luyan Gu Zuhai Lei Jianming Bao Jiahui Wu Tingting He Fupin Hu Jing Zheng Honglin Li Weiping Zhu Lei Shao Xiaojing Dong Daijie Chen Xuhong Qian Youjun Yang Antimicrobial resistance is a public health

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

The nuclear import receptor karyopherin β1 (KPNB1) is involved in the nuclear import of most proteins and in the regulation of multiple mitotic events. Upregulation of KPNB1 has been observed in cancers including glioblastoma. Depletion of KPNB1 induces mitotic arrest and apoptosis in cancer cells, but the underlying mechanism is not clearly elucidated. Here, we found that...

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals

Liu, Jing Zheng, Zhimin Huang, Xiaopei Cao, and Haipeng Xiao collected parts of the data. Yanbing Li designed the study and reviewed the paper. Acknowledgments The authors are grateful to all

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals

Juan Liu and Jianbin Liu contributed equally to this study; they collected and analyzed the data and wrote the paper. Hai Li, Liehua Liu, Jing Zheng, Zhimin Huang, Xiaopei Cao, and Haipeng Xiao collected

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals

Juan Liu and Jianbin Liu contributed equally to this study; they collected and analyzed the data and wrote the paper. Hai Li, Liehua Liu, Jing Zheng, Zhimin Huang, Xiaopei Cao, and Haipeng Xiao collected

Clarifying the molecular mechanism associated with carfilzomib resistance in human multiple myeloma using microarray gene expression profile and genetic interaction network

, Jing Zheng, Jianda Hu Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China Abstract: Carfilzomib ... Zhihong Zheng Tingbo Liu Jing Zheng Jianda hu 0 0 Department of h ematology, Fujian Provincial Key Laboratory of hematology, Fujian Medical University Union Hospital , Fuzhou, Fujian , People's Republic of

Orthogonal navigation of multiple visible-light-driven artificial microswimmers

), the URC Strategic Research Theme on Clean Energy (University of Hong Kong), and the URC Strategic Research Theme on New Materials (University of Hong Kong). Author information Author notes Jing Zheng ... Liu, Xiaojun Zhan, Zhihan Wan & Jinyao Tang AuthorsSearch for Jing Zheng in:Nature Research journals • PubMed • Google Scholar Search for Baohu Dai in:Nature Research journals • PubMed • Google

Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken

In recent years, avian influenza virus H9N2 undergoing antigenic drift represents a threat to poultry farming as well as public health. Current vaccines are restricted to inactivated vaccine strains and their related variants. In this study, a recombinant H9N2 (H9N2-TM) strain with a replaced H3 hemagglutinin (HA) transmembrane (TM) domain was generated. Virus assembly and viral...

Experimental Verification of New Function Theories of Particles (1)-Experimental Verification of New Kinetic Energy Theorem of Rigid Body Fixed Axis Rotation

Sliding friction torque does dissipative work on the force-bearer, transforming the kinetic energy of the bearer into internal energy and others of the bearer. Sliding friction countertorque does dissipative work on the applying body, transforming the kinetic energy of the bearer into internal energy and others of the applying body. In the experiment, the dissipative work done by...

Recommendation in heterogeneous information network via dual similarity regularization

Recommender system has caught much attention from multiple disciplines, and many techniques are proposed to build it. Recently, social recommendation becomes a hot research direction. The social recommendation methods tend to leverage social relations among users obtained from social network to alleviate data sparsity and cold-start problems in recommender systems. It employs...

An Efficient Approach for Solving Optimization over Linear Arithmetic Constraints

Joint Conference on Automated Reasoning , June 2012 , pp. 339 - 354 . Jing-Zheng Wu is an associate research professor of the Institute of Software, Chinese Academy of Sciences, Beijing. He received his

Vibrator Data Denoising Based on Fractional Wavelet Transform

In this paper, a novel data denoising method is proposed for seismic exploration with a vibrator which produces a chirp-like signal. The method is based on fractional wavelet transform (FRWT), which is similar to the fractional Fourier transform (FRFT). It can represent signals in the fractional domain, and has the advantages of multi-resolution analysis as the wavelet transform...

Flattening Filter-Free Beams in Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy for Sinonasal Cancer

Purpose To evaluate the dosimetric impacts of flattening filter-free (FFF) beams in intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for sinonasal cancer. Methods For fourteen cases, IMRT and VMAT planning was performed using 6-MV photon beams with both conventional flattened and FFF modes. The four types of plans were compared in terms of...

Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3’s Function

Cadherin-related 23 (CDH23) is an adhesive protein important for hearing and vision, while CAMSAP3/Marshalin is a microtubule (MT) minus-end binding protein that regulates MT networks. Although both CDH23 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein interaction domains, no functional connection between these two proteins has been...

A Prediction Model for ROS1-Rearranged Lung Adenocarcinomas based on Histologic Features

Aims To identify the clinical and histological characteristics of ROS1-rearranged non-small-cell lung carcinomas (NSCLCs) and build a prediction model to prescreen suitable patients for molecular testing. Methods and Results We identified 27 cases of ROS1-rearranged lung adenocarcinomas in 1165 patients with NSCLCs confirmed by real-time PCR and FISH and performed univariate and...

A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function

In this report, we investigated the pathogenic mechanism underlying the deafness-associated mitochondrial(mt) tRNAAsp 7551A > G mutation. The m.7551A > G mutation is localized at a highly conserved nucleotide(A37), adjacent (3′) to the anticodon, which is important for the fidelity of codon recognition and stabilization in functional tRNAs. It was anticipated that the m.7551A > G...

Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice

A knockin (KI) mouse expressing mutated prestinV499G/Y501H (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs were normal in stiffness and longer than OHCs lacking prestin, accelerated OHC death...

Charge-to-mass Ratio of Saltating Particles in Wind-Blown Sand

Electronical and Machanical Engineering, Xidian University, Xi'an, 710071, ChinaXiao-Jing Zheng AuthorsSearch for Tian-Li Bo in:Nature Research journals • PubMed • Google ScholarSearch for Huan Zhang in:Nature ... Research journals • PubMed • Google ScholarSearch for Xiao-Jing Zheng in:Nature Research journals • PubMed • Google Scholar Contributions T.B. and X.Z. wrote the main manuscript text and H.Z. prepared

A Solution to Reconstruct Cross-Cut Shredded Text Documents Based on Character Recognition and Genetic Algorithm

The reconstruction of destroyed paper documents is of more interest during the last years. This topic is relevant to the fields of forensics, investigative sciences, and archeology. Previous research and analysis on the reconstruction of cross-cut shredded text document (RCCSTD) are mainly based on the likelihood and the traditional heuristic algorithm. In this paper, a feature...