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Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations

Compound Distribution Program sponsored by Cystic Fibrosis Foundation Therapeutics (Bethesda, MD, USA) for providing GlyH-101 and CFTRinh-172. Author Contributions Conceptualization: Jingyao Zhang, Tzyh ... -Chang Hwang. 15 / 20 Formal analysis: Jingyao Zhang, Ying-Chun Yu, Jiunn-Tyng Yeh. Investigation: Jingyao Zhang, Ying-Chun Yu, Jiunn-Tyng Yeh. Methodology: Jingyao Zhang. Project administration

Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties

, China Correspondence should be addressed to Chang Liu; moc.361@rotcodgnahcuil and Jingyao Zhang; moc.361@yuo21uoy Received 19 November 2017; Revised 12 January 2018; Accepted 21 January 2018; Published ... Liu and Jingyao Zhang provided substantial advice in designing the study and revising the paper. Yifan Jia and Zeyu Li contribute equally to the paper. Acknowledgments The authors are indebted to all

Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties

, China Correspondence should be addressed to Chang Liu; moc.361@rotcodgnahcuil and Jingyao Zhang; moc.361@yuo21uoy Received 19 November 2017; Revised 12 January 2018; Accepted 21 January 2018; Published ... Liu and Jingyao Zhang provided substantial advice in designing the study and revising the paper. Yifan Jia and Zeyu Li contribute equally to the paper. Acknowledgments The authors are indebted to all

Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments

.361@rotcodgnahcuil Received 1 October 2017; Revised 18 December 2017; Accepted 29 March 2018; Published 16 April 2018 Academic Editor: Ruchi Bansal Copyright © 2018 Jingyao Zhang et al. This is an ... substantial advice in designing the study and assisting in the division of labor. Jingyao Zhang and Ruixia Cui contributed equally to this work. Acknowledgments The authors are indebted to all individuals who

Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments

.361@rotcodgnahcuil Received 1 October 2017; Revised 18 December 2017; Accepted 29 March 2018; Published 16 April 2018 Academic Editor: Ruchi Bansal Copyright © 2018 Jingyao Zhang et al. This is an ... substantial advice in designing the study and assisting in the division of labor. Jingyao Zhang and Ruixia Cui contributed equally to this work. Acknowledgments The authors are indebted to all individuals who

Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice

University, Xi’an Shaanxi, 710061, People’s Republic of ChinaChang Liu & Jingyao Zhang AuthorsSearch for Jianbin Bi in:Nature Research journals • PubMed • Google Scholar Search for Simin Zhang in:Nature ... for Yan Deng in:Nature Research journals • PubMed • Google Scholar Search for Chang Liu in:Nature Research journals • PubMed • Google Scholar Search for Jingyao Zhang in:Nature Research journals

5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

January 2017; Accepted 30 April 2017; Published 13 June 2017 Academic Editor: Ulrich Eisel Copyright © 2017 Jingyao Zhang et al. This is an open access article distributed under the Creative Commons ... ’ Contributions Jingyao Zhang and Jianbin Bi participated in the research design and writing of the paper; they contributed equally to the work. Sushun Liu participated in the research design and literature review

5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

January 2017; Accepted 30 April 2017; Published 13 June 2017 Academic Editor: Ulrich Eisel Copyright © 2017 Jingyao Zhang et al. This is an open access article distributed under the Creative Commons ... ’ Contributions Jingyao Zhang and Jianbin Bi participated in the research design and writing of the paper; they contributed equally to the work. Sushun Liu participated in the research design and literature review

Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-κB Activation

BST2 (CD317, tetherin, HM1.24) is an interferon-inducible transmembrane protein which can directly inhibit the release of enveloped virus particles from infected cells, and its anti-viral activity is reported to be related to the specific topological arrangement of its four structural domains. The N-terminal cytoplasmic tail of feline BST2 (fBST2) is characterized by a shorter N...

Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice

Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University; NO.277 Yanta West Road, Xi'an Shaanxi 710061, People's Republic of ChinaQifei Wu AuthorsSearch for Jingyao Zhang in:Nature

Role of cullin-elonginB-elonginC E3 complex in bovine immunodeficiency virus and maedi-visna virus Vif-mediated degradation of host A3Z2-Z3 proteins

Background All lentiviruses except equine infectious anemia virus (EIVA) antagonize antiviral family APOBEC3 (A3) proteins of the host through viral Vif proteins. The mechanism by which Vif of human, simian or feline immunodeficiency viruses (HIV/SIV/FIV) suppresses the corresponding host A3s has been studied extensively. Results Here, we determined that bovine immunodeficiency...

Tolerogenic Vaccination Reduced Effector Memory CD4 T Cells and Induced Effector Memory Treg Cells for Type I Diabetes Treatment

Background Vaccination could induce immune tolerance and protected NOD mice from the development of type I diabetes (T1D). We previously demonstrated that insulin peptide (B9-23) combined with dexamethasone (DEX) stimulated the expansion of antigen specific regulatory T (Treg) cells which in turn effectively prevented T1D in NOD mice. Here, we aimed to investigate the therapeutic...

Treg Cell Resistance to Apoptosis in DNA Vaccination for Experimental Autoimmune Encephalomyelitis Treatment

Background Regulatory T (Treg) cells can be induced with DNA vaccinations and protect mice from the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Tacrolimus (FK506) has been shown to have functions on inducing immunosuppression and augmenting apoptosis of pathologic T cells in autoimmune disease. Here we examined the...

Epitope Tags beside the N-Terminal Cytoplasmic Tail of Human BST-2 Alter Its Intracellular Trafficking and HIV-1 Restriction

BST-2 blocks the particle release of various enveloped viruses including HIV-1, and this antiviral activity is dependent on the topological arrangement of its four structural domains. Several functions of the cytoplasmic tail (CT) of BST-2 have been previously discussed, but the exact role of this domain remains to be clearly defined. In this study, we investigated the impact of...

Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif

Background The HIV-1 accessory factor Vif is necessary for efficient viral infection in non-permissive cells. Vif antagonizes the antiviral activity of human cytidine deaminase APOBEC3 proteins that confer the non-permissive phenotype by tethering them (APOBEC3DE/3F/3G) to the Vif-CBF-β-ElonginB-ElonginC-Cullin5-Rbx (Vif-CBF-β-EloB-EloC-Cul5-Rbx) E3 complex to induce their...

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence

Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homologous protein TcpC was recently identified as a virulence factor in uropathogenic Escherichia coli (E. coli), suppressing innate...