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WRF-Chem modeling of particulate matter in the Yangtze River Delta region: Source apportionment and its sensitivity to emission changes

Jingyi Li 0 1 Xin Long 1 0 Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology ... acquisition: Nan Li. Methodology: Nan Li, Jingyi Li, Xin Long. Supervision: Hong Liao. Visualization: Nan Li. Writing ? original draft: Nan Li. Writing ? review & editing: Nan Li, Qingyang He. 13 / 15 14

Tubeimoside I induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function

Municipal Education Commission (Grant No. KJQN201800429). Author information Author notes These authors contributed equally: Xuping Feng, Jing Zhou, Jingyi Li AffiliationsDepartment of Biochemistry and ... AuthorsSearch for Xuping Feng in:Nature Research journals • PubMed • Google Scholar Search for Jing Zhou in:Nature Research journals • PubMed • Google Scholar Search for Jingyi Li in:Nature Research journals

Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants

As shown in our previous study, two alternatively spliced androgen receptor (AR) variants, which are exclusively expressed in the granulosa cells of patients with polycystic ovary syndrome, exhibit retarded nuclear translocation compared with wild-type AR. However, researchers have not yet determined whether these abnormalities correlate with heat shock protein 90 (HSP90) and...

Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET

assisted conception. KeywordsDiminished ovarian reserve Live-birth rate In vitro fertilization and embryo transfer Impact factors Cohort study  Yun Huang and Jingyi Li contributed equally to this work

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi l l i t Song and Jing Qu declare that they have no conflict of interest. All institutional and national guidelines for

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling

). Author information Author notes Jingyi Li and Meiying Zhang contributed equally to this work. AffiliationsDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853 ... Jingyi Li in:Nature Research journals • PubMed • Google Scholar Search for Meiying Zhang in:Nature Research journals • PubMed • Google Scholar Search for Tao He in:Nature Research journals • PubMed

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that homozygous knock-in mice carrying a point mutation at the Ser86 phosphorylation site of acetyltransferase Tip60 (Tip60SA/SA) display...

Epigenome overlap measure (EPOM) for comparing tissue/cell types based on chromatin states

Background The dynamics of epigenomic marks in their relevant chromatin states regulate distinct gene expression patterns, biological functions and phenotypic variations in biological processes. The availability of high-throughput epigenomic data generated by next-generation sequencing technologies allows a data-driven approach to evaluate the similarities and differences of...

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non-tumor tissue. This study aimed to elucidate the underlying mechanisms of PTHLH in ICC development. The CCK-8 assay, colony formation assays, flow cytometry and a xenograft...

Toxicity of TiO2 Nanoparticles to Escherichia coli: Effects of Particle Size, Crystal Phase and Water Chemistry

Controversial and inconsistent results on the eco-toxicity of TiO2 nanoparticles (NPs) are commonly found in recorded studies and more experimental works are therefore warranted to elucidate the nanotoxicity and its underlying precise mechanisms. Toxicities of five types of TiO2 NPs with different particle sizes (10∼50 nm) and crystal phases were investigated using Escherichia...

One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities

, Lanzhou University, China, 730000Yulong Sun, Tao Sun, Luping Liu, Xiaoyuan Zhang, Jingyi Li, Yan Zhuang & Rui WangAnesthesia department of Gansu Provincial Hospital, China, 730000Shaoli DingKey Laboratory ... • Google ScholarSearch for Shaoli Ding in:Nature Research journals • PubMed • Google ScholarSearch for Jingyi Li in:Nature Research journals • PubMed • Google ScholarSearch for Yan Zhuang in:Nature Research

Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing

, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Hong Wang, Yong Zhang & Shaorong GaoGraduate School of Peking Union Medical College, Beijing, ChinaXiaoyu Liu & Shaorong ... journals • PubMed • Google ScholarSearch for Yanhong Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Jingyi Li in:Nature Research journals • PubMed • Google ScholarSearch for You Wu

Optical Imaging of Paramagnetic Bead-DNA Aggregation Inhibition Allows for Low Copy Number Detection of Infectious Pathogens

DNA-paramagnetic silica bead aggregation in a rotating magnetic field facilitates the quantification of DNA with femtogram sensitivity, but yields no sequence-specific information. Here we provide an original description of aggregation inhibition for the detection of DNA and RNA in a sequence-specific manner following loop-mediated isothermal amplification (LAMP). The fragments...

Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling of DNA methylation in circulating cell-free DNA (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification and sequencing (MCTA-Seq) method that can detect thousands of hypermethylated CpG islands simultaneously in ccfDNA. This highly sensitive...

Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice

Myeloid cells have a critical role in maintaining intestinal homeostasis and regulating the development of inflammatory bowel disease and colitis-associated cancer (CAC). However, the signaling pathways that control the function of colonic myeloid cells in these pathological processes are still poorly defined. In this study, we demonstrate that transforming growth factor-β (TGF...

Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPARγ Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells

Emerging evidence suggests that tumor-initiating cells (TICs) are the most malignant cell subpopulation in tumors because of their resistance to chemotherapy or radiation treatment. Targeting TICs may be a key innovation for cancer treatment. In this study, we found that PPARγ agonists inhibited the cancer stem cell-like phenotype and attenuated tumor growth of human...

The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis

Introduction Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. The renal involvement is commonly characterised by a pauci-immune crescentic glomerulonephritis (PiCGN) with a very rapid decline in renal function. Cathelicidin LL37, an endogenous antimicrobial peptide, has recently...

HIV Infection in Gastric Epithelial Cells

Many chronic human immunodeficiency virus (HIV) patients suffer from gastric complaints, including gastric tuberculosis and coinfection of other pathogens. Recent work has demonstrated that a variety of nonimmune cells can act as viral reservoirs, even at the early stage of HIV infection. In this study, we detect HIV viral particles, proteins, and nucleic acids in gastric...

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis

Introduction Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA). Methods The expression profile of miRNAs in CD4+ T cells from synovial fluid (SF) and peripheral...