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Maternal diet before and during pregnancy and risk of asthma and allergic rhinitis in children

Consumption of certain foods during pregnancy has been shown to have beneficial effects on childhood asthma and allergic disease development and aggravation. However, most studies provide conflicting results and the relationships between maternal preconceptional diet and risks of childhood asthma and allergic disease have not previously been explored. The objective of this study...

Pretreatment by omalizumab allows allergen-specific immunotherapy in children and young adult with severe allergic asthma

Tamazoust Guiddir 0 Jocelyne Just 0 Flore Amat 0 0 Armand Trousseau Children's Hospital, Allergology Department , Paris , France 2015 Lambert et al; licensee BioMed Central Ltd. This is an Open Access

Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study

Background The classification of rhinitis in adults is missing in epidemiological studies. Objective To identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach. Methods 983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms...

Determinants of Allergic Rhinitis in Young Children with Asthma

Background In the preschool period, allergic rhinitis (AR) is infrequent and thus under-diagnosed. However, recent works have highlighted the occurrence of AR in toddlers although the causes of AR in this young population remain unknown. The objective of this study was to identify determinants of AR in young children with asthma. Methods We carried out a case-control study of 227...

An EAACI “European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI)”: the methodology

Moises A Caldern 0 Pablo Rodrguez del Ro Carmen Vidal Jocelyne Just Oliver Pfaar Allan Linneberg Pascal Demoly 0 Section of Allergy and Clinical Immunology, Imperial College London, National Heart

An EAACI “European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI)”: the methodology

At present, there is no European report on clinically relevant systemic reactions due to the regular use of allergen immunotherapy (AIT), administered either subcutaneously or sublingually (SCIT and SLIT, respectively) outside clinical trials. Using an electronic survey and a “harmonised terminology” according to MedDRA, we aimed to prospectively collect systemic adverse...

Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort

Background Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term “atopic march”. However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma. Methods We performed a cluster...

The emerging landscape of dynamic DNA methylation in early childhood

Background DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood. Results By analysing 538 paired DNA blood samples from children at birth and at 4–5 years old and 726 paired samples from children at 4 and 8 years old from four European birth...

The emerging landscape of dynamic DNA methylation in early childhood

DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood. By analysing 538 paired DNA blood samples from children at birth and at 4–5 years old and 726 paired samples from children at 4 and 8 years old from four European birth cohorts using the...

EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy

Bousquet Aziz Sheikh Anthony Frew Glenis Scadding Claus Bachert Hans J Malling Rudolph Valenta Beatrice Bilo Antonio Nieto Cezmi Akdis Jocelyne Just Carmen Vidal Eva M Varga Emilio Alvarez-Cuesta Barbara

EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy

Allergy today is a public health concern of pandemic proportions, affecting more than 150 million people in Europe alone. In view of epidemiological trends, the European Academy of Allergy and Clinical Immunology (EAACI) predicts that within the next few decades, more than half of the European population may at some point in their lives experience some type of allergy. Not only...

Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families

Christine Kra¨ henbu¨ hl 3 Arnaud Lemainque 0 Isabella Annesi-Maesano 7 Christine Betard 0 Jean Bousquet 6 Denis Charpin 5 Fre´ de´ ric Gormand 4 Michel Guilloud-Bataille 1 Jocelyne Just 9 Nicole Le Moual 7