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Thermotoga maritima NusG: domain interaction mediates autoinhibition and thermostability

NusG, the only universally conserved transcription factor, comprises an N- and a C-terminal domain (NTD, CTD) that are flexibly connected and move independently in Escherichia coli and other organisms. In NusG from the hyperthermophilic bacterium Thermotoga maritima (tmNusG), however, NTD and CTD interact tightly. This closed state stabilizes the CTD, but masks the binding sites...

Determination of RNA polymerase binding surfaces of transcription factors by NMR spectroscopy

Strauß Present address: Columbia University Medical Center, New York, NY 10032, USA. Johanna Drögemüller & Martin Strauß These authors contributed equally to this work. AffiliationsLehrstuhl Biopolymere ... H. Knauer AuthorsSearch for Johanna Drögemüller in:Nature Research journals • PubMed • Google ScholarSearch for Martin Strauß in:Nature Research journals • PubMed • Google ScholarSearch for Kristian

Exploring RNA polymerase regulation by NMR spectroscopy

, GermanyJohanna Drögemüller, Martin Strauß, Kristian Schweimer, Birgitta M. Wöhrl, Stefan H. Knauer & Paul Rösch AuthorsSearch for Johanna Drögemüller in:Nature Research journals • PubMed • Google ScholarSearch for