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52 papers found.
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Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study

Confidence interval mTORC1 Mechanistic target of rapamycin complex 1 OR odds ratio Communicated by Mario Bianchetti Hilde K. Brekke and Johnny Ludvigsson acted as equivalent senior authors

Exploring C-peptide loss in type 1 diabetes using growth curve analysis

curation: Johnny Ludvigsson. Formal analysis: Rachel E. J. Besser, Tim J. Cole. Funding acquisition: Johnny Ludvigsson. Investigation: Rachel E. J. Besser, Johnny Ludvigsson, Tim J. Cole. Methodology ... : Tim J. Cole. Project administration: Johnny Ludvigsson. Resources: Johnny Ludvigsson. Software: Tim J. Cole. Supervision: Tim J. Cole. Writing ± original draft: Rachel E. J. Besser, Tim J. Cole

Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes

Barcenilla,1 Jeannette Wahlberg,2 Peter Achenbach,3 Johnny Ludvigsson,1,4 and Rosaura Casas1 1Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences ... patient privacy. Disclosure The current address of Johnny Ludvigsson is Division of Pediatrics, Department of Clinical and Experimental Medicine, Medical Faculty of Linköping University, 581 85 Linköping

Serum miRNA levels are related to glucose homeostasis and islet autoantibodies in children with high risk for type 1 diabetes

: Linda Åkerman. Conceptualization: Linda Åkerman, Johnny Ludvigsson, Camilla Skoglund. Formal analysis: Linda Åkerman, Beatriz Tavira, Camilla Skoglund. Funding acquisition: Rosaura Casas, Johnny ... Ludvigsson, Camilla Skoglund. Investigation: Linda Åkerman. Methodology: Linda Åkerman. Project administration: Linda Åkerman, Johnny Ludvigsson, Camilla Skoglund. Resources: Rosaura Casas, Johnny

Two Insulin Gene Single Nucleotide Polymorphisms Associated with Type 1 Diabetes Risk in the Finnish and Swedish Populations

We have developed high-throughput tests for the detection of the insulin gene region SNPs −23HphI and −2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time...

Worm infestations and development of autoimmunity in children – The ABIS study

project leader Johnny Ludvigsson, who can show where the minimal underlying data set for this study can be found in ABIS biobank register. Ethics The ABIS study has been approved by the Research Ethics

Author’s Reply to Dayal: “Therapies to Preserve β-Cell Function in Type 1 Diabetes”

Drugs Author's Reply to Dayal: ''Therapies to Preserve b-Cell Function in Type 1 Diabetes'' Johnny Ludvigsson 0 1 0 Division of Pediatrics, Department of Clinical and Experimental Medicine, Linko ... ̈ping University , 58185 Linko ̈ping , Sweden 1 & Johnny Ludvigsson - In his comment [ 1 ] on ‘‘Therapies to Preserve b-Cell Function in Type 1 Diabetes’’ [ 2 ], Devi Dayal, while overall very

Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children

islet autoantibodies to insulin (IAA), GAD (GADA), tyrosine phosphatase 2 (IA-2A) and zinc transporter Paolo Pozzilli, Johnny Ludvigsson and Ahuva Nissim share senior authorship. Biomarker; Insulin

Effect of simultaneous vaccination with H1N1 and GAD-alum on GAD65-induced immune response

registration: ClinicalTrials.gov NCT00723411. Children; GAD; H1N1; Immune intervention; Type 1 diabetes; Vaccine - Johnny Ludvigsson and Rosaura Casas contributed equally to this study. Abbreviations GADA

Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study

Aim To further elucidate the relationship between physical activity and several risk factors for development of diabetes (glucose, C-peptide and obesity) over time. Methods A prospective longitudinal study where physical activity was measured on 199 children from Kalmar and Linköping at age 8, and the same 107 children from Linköping again at age 12. Anthropometric data was...

High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases

, Sweden 1 Johnny Ludvigsson and Annika Thorsell are joint last authors 2 Department of Medicine and Health Sciences, Community Medicine/General Practice, Linkoping University , Linkoping 58183 , Sweden 3

GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis

Aims/hypothesis GAD is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. Randomised controlled clinical trials of a GAD + alum vaccine in human participants have so far given conflicting results. Methods In this study, we sought to see whether a clearer answer to the question of whether GAD65 has an effect on C-peptide could be reached by...

Update on Treatment of Type 1 Diabetes in Childhood

Johnny Ludvigsson 0 0 J. Ludvigsson (&) Division of Pediatrics, Department of Clinical and Experimental Medicine, Linkoping University , 58185, Linkoping, Sweden After 90 years of using insulin to

Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study

Johnny Ludvigsson 0 Anneli Frostell 0 0 J. Carstensen Division of Health and Society, Department of Medical and Health Sciences, Linköping University , Linköping , Sweden Aims/hypothesis The aim of this ... ; Stressful events; Type 1 diabetes mellitus - Johnny Ludvigsson and Anneli Frostell are joint senior authors on this paper. Introduction The aetiology behind type 1 diabetes is unknown, but both genetic

Antibiotic exposure in pregnancy and risk of coeliac disease in offspring: a cohort study

Background The infant microbiota may play a pathogenic role in coeliac disease (CD). Antibiotic treatment in pregnancy is common and could significantly impact the infant microbiota. In this study, we aimed to investigate the association between antibiotic exposure during pregnancy and CD in offspring. Methods Prospective questionnaire data on antibiotic exposure in pregnancy...

Impact of HbA1c, Followed From Onset of Type 1 Diabetes, on the Development of Severe Retinopathy and Nephropathy: The VISS Study (Vascular Diabetic Complications in Southeast Sweden)

Meryl Dhir Mats Fredrikson Johnny Ludvigsson Hans J. Arnqvist RESEARCH DESIGN AND METHODS A longitudinal observation study followed an unselected population of 451 patients diagnosed with type 1 diabetes

General immune dampening is associated with disturbed metabolism at diagnosis of type 1 diabetes

Background:Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D.Methods:Sixty-nine newly diagnosed T1D children were studied together with a reference group...

Cellular and Humoral Immune Responses in Type 1 Diabetic Patients Participating in a Phase III GAD-alum Intervention Trial

OBJECTIVE GAD formulated in aluminum hydroxide (GAD-alum) has previously been shown to induce preservation of residual insulin secretion in recent-onset type 1 diabetes, but recent phase II and III GAD-alum trials failed to reach primary outcomes. The European phase III study was therefore closed after 15 months, and only a minority of patients completed the 30 months of follow-up.