Advanced search    

Search: authors:"Jonathan Beesley"

42 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer

Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition...

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

Leonie C. Jacobs 10 13 David M. Evans 11 12 13 Jonathan Beesley 6 13 14 Matthew H. Law 13 Peter Kraft 6 13 15 Alessia Visconti 13 John C. Taylor 8 13 Fan Liu 13 16 Margaret J. Wright 13 Anjali K. Henders 6

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690, have been identified within the hTERT gene. The minor allele (A) at rs10069690 creates an additional splice donor site in...

Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab

Xiaoqing?Chen Jonathan?Beesley Emmanuella?Bimeh Daniel?Barrowdale Esther?M.?John Mary?B.?Daly Irene?L.?Andrulis Saundra?S.?Buys Peter?Kraft kConFab investigators 3 Heather?Thorne Georgia?Chenevix-Trench

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Introduction Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear. Methods We used morphology, immunohistochemistry, gene expression and somatic mutation profiling to analyze 39 matched pairs of primary breast cancers and...

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers

-Villars Laurence Faivre Laurence Venat-Bouvet Capucine Delnatte Heli Nevanlinna Fergus J Couch Andrew K Godwin Maria Adelaide Caligo SWE-BRCA Rosa B Barkardottir kConFab Investigators Xiaoqing Chen Jonathan ... Beesley Sue Healey Carlos Caldas 0 Georgia Chenevix-Trench Bruce AJ Ponder 0 0 Cambridge Research Institute - CRUK, Li Ka Shing Centre, Cancer Research UK , Robinson Way, Cambridge, CB2 0RE , UK 1 Institute

ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

Background ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown.

Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer development

Multiple lines of evidence suggest regulatory variation to play an important role in phenotypic evolution and disease development, but few regulatory polymorphisms have been characterized genetically and molecularly. Recent technological advances have made it possible to identify bona fide regulatory sequences experimentally on a genome-wide scale and opened the window for the...

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

, Pontificia Universidad Javeriana, Bogota, ColombiaDiana Torres AuthorsSearch for Hatef Darabi in:Nature Research journals • PubMed • Google ScholarSearch for Jonathan Beesley in:Nature Research journals

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

-Trench AOCS/ACS Study Group Jonathan Beesley Penelope M. Webb Andrew Berchuck Joellen M. Schildkraut Edwin S. Iversen Patricia G. Moorman Christopher K. Edlund Daniel O. Stram Malcolm C. Pike Roberta B

Estrogen Receptor Beta rs1271572 Polymorphism and Invasive Ovarian Carcinoma Risk: Pooled Analysis within the Ovarian Cancer Association Consortium

Peter A. Fasching Matthias W. Beckmann Arif B. Ekici Alexander Hein Georgia Chenevix-Trench Penelope M. Webb Jonathan Beesley The Australian Ovarian Cancer Study Australian Cancer Study Groups Marc T ... , Jonathan Beesley, Xiaoqing Chen, Penelope M. Webb, The Australian Cancer Study (Ovarian Cancer), The Australian Ovarian Cancer Study Group, The Queensland Institute of Medical Research, Queensland; Peter

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

John R.B. Perry Yi-Hsiang Hsu Daniel I. Chasman Andrew D. Johnson Cathy Elks Eva Albrecht Irene L. Andrulis Jonathan Beesley Gerald S. Berenson Sven Bergmann Stig E. Bojesen Manjeet K. Bolla Judith

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer...

Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk

Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer. To evaluate the role of genetic variants at the TERT–CLPTM1L region in endometrial cancer risk, we carried out comprehensive fine-mapping analyses...

Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers

Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional...

Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

. Schildkraut Ya-Yu Tsai Susan J. Ramus Brooke L. Fridley Jonathan Beesley Sharon E. Johnatty Penelope M. Webb Georgia Chenevix-Trench Australian Ovarian Cancer Study Group Laura C. Dale Diether Lambrechts

Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”

the participating studies. The Ovarian Cancer Association Consortium Georgia Chenevix-Trench, Sharon E. Johnatty, Jonathan Beesley, Xiaoqing Chen, Penelope M. Webb, The Australian Cancer Study