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13 papers found.
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Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest

• PubMed • Google Scholar Search for Ivana Grbeša in:Nature Research journals • PubMed • Google Scholar Search for Robert Belužić in:Nature Research journals • PubMed • Google Scholar Search for Jong Hoon ... Park in:Nature Research journals • PubMed • Google Scholar Search for Hyun Kyung Kong in:Nature Research journals • PubMed • Google Scholar Search for Nevenka Kopjar in:Nature Research journals

Quantitative analysis of neural tissues around the optic disc after panretinal photocoagulation in patients with diabetic retinopathy

Seung Yang, June-Gone Kim, Jong Eun Woo. Methodology: Hyun Seung Yang, Jae Bong Cha, Jong Eun Woo. Supervision: June-Gone Kim, Jong Hoon Park. Validation: June-Gone Kim. Writing ± original draft: Hyun

Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models

design and the preparation of MS. Competing Interests The authors declare that they have no competing interests. Corresponding author Correspondence to Jong Hoon Park. Electronic supplementary ... • PubMed • Google Scholar Search for Eun Young Park in:Nature Research journals • PubMed • Google Scholar Search for Jinwoong Bok in:Nature Research journals • PubMed • Google Scholar Search for Jong Hoon

Hydrolyzed collagen intake increases bone mass of growing rats trained with running exercise

Background Some studies have shown that dietary hydrolyzed collagen peptides (HC) effectively prevent age-related bone loss. However, it is not known whether the intake of HC also has positive effect on bone mass or strength when combined with exercise during growth phase. Methods We examined the effects of 11 weeks of HC intake and running exercise on bone mass and strength in...

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

Tamoxifen resistance is often observed in the majority of estrogen receptor–positive breast cancers and it remains as a serious clinical problem in breast cancer management. Increased aerobic glycolysis has been proposed as one of the mechanisms for acquired resistance to chemotherapeutic agents in breast cancer cells such as adriamycin. Herein, we report that the glycolysis...

How much locomotive activity is needed for an active physical activity level: analysis of total step counts

Background Although physical activity recommendations for public health have focused on locomotive activity such as walking and running, it is uncertain how much these activities contribute to overall physical activity level (PAL). The purpose of the present study was to determine the contribution of locomotive activity to PAL using total step counts measured in a calorimeter...

Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney Disease

Mass effect from polycystic kidney and liver enlargement can result in significant clinical complications and symptoms in autosomal dominant polycystic kidney disease (ADPKD). In this single-center study, we examined the correlation of height-adjusted total liver volume (htTLV) and total kidney volume (htTKV) by CT imaging with hepatic complications (n = 461) and abdominal...

Bone marrow-derived, alternatively activated macrophages enhance solid tumor growth and lung metastasis of mammary carcinoma cells in a Balb/C mouse orthotopic model

Tumor-associated macrophages, which are derived from the infiltration of circulating bone marrow-derived monocytes, consist primarily of a polarized M2 macrophage (M2-Mϕ) population and are associated with poor prognosis in various cancers. In the present study, we attempted to assess whether M2-Mϕs derived from bone marrow stimulate the promotion and progression of mammary...

Gas Nozzle Effect on the Deposition of Polysilicon by Monosilane Siemens Reactor

Deposition of polysilicon (poly-Si) was tried to increase productivity of poly-Si by using two different types of gas nozzle in a monosilane Bell-jar Siemens (MS-Siemens) reactor. In a mass production of poly-Si, deposition rate and energy consumption are very important factors because they are main performance indicators of Siemens reactor and they are directly related with the...

Gas Nozzle Effect on the Deposition of Polysilicon by Monosilane Siemens Reactor

Deposition of polysilicon (poly-Si) was tried to increase productivity of poly-Si by using two different types of gas nozzle in a monosilane Bell-jar Siemens (MS-Siemens) reactor. In a mass production of poly-Si, deposition rate and energy consumption are very important factors because they are main performance indicators of Siemens reactor and they are directly related with the...

PEP-1-PON1 Protein Regulates Inflammatory Response in Raw 264.7 Macrophages and Ameliorates Inflammation in a TPA-Induced Animal Model

Paraoxonase 1 (PON1) is an antioxidant enzyme which plays a central role in various diseases. However, the mechanism and function of PON1 protein in inflammation are poorly understood. Since PON1 protein alone cannot be delivered into cells, we generated a cell permeable PEP-1-PON1 protein using protein transduction domains, and examined whether it can protect against cell death...

Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) occurs by germline mutation in PKD1 or PKD2. Evidence of homozygous inactivation of either gene in human cyst lining cells as well as in mouse knockout models strongly supports a two-hit mechanism for cyst formation. Discovery of trans-heterozygous mutations in PKD1 and PKD2 in a minority of human renal cysts has led to the...