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Search: authors:"Jong Kyu Woo"

7 papers found.
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Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells

The transmembrane nerve injury-induced protein 1 (Ninjurin1 or Ninj1) is involved in progressing inflammatory diseases. In this study, we aimed to investigate a novel function of Ninj1 in pulmonary fibrosis. We found that the expression of Ninj1 in a patient cohort was upregulated in the lung specimens of idiopathic pulmonary fibrosis patients as well as mice with bleomycin...

Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression

, Seoul National University, Seoul, 08826, Republic of KoreaJe Kyung Seong AuthorsSearch for Jong Kyu Woo in:Nature Research journals • PubMed • Google Scholar Search for Jae Hoon Shin in:Nature Research

Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model

BackgroundInflammatory bowel disease (IBD) is characterized by chronic or relapsing immune system activation and inflammation within the gastrointestinal tract. The lack of safety and efficacy of standard therapies, the use of food supplements for managing IBD is increasing, and many studies have reported that various food supplements provide many beneficial effects for the IBD...

The novel IGF-IR/Akt–dependent anticancer activities of glucosamine

Ki-Hoon Song Ju-Hee Kang Jong-Kyu Woo 1 Jeong-Seok Nam Hye-Young Min Ho-Young Lee Soo-Youl Kim Seung-Hyun Oh 0 1 0 College of Pharmacy, Gachon University , 7-45 Songdo-dong, Yeonsu-gu, Incheon 406

The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1

Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF-κB activation. We previously reported that the C-terminal region of Bfl-1 fused with GFP (BC) is sufficient to induce apoptosis in 293T cells. In the present study, we...

Structural Basis for Depletion of Heat Shock Protein 90 Client Proteins by Deguelin

Background The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of various oncoproteins, including hypoxia-inducible factor 1α (HIF-1α) and Akt. Deguelin is a rotenoid with antitumor activities. We investigated whether the antitumor activities of deguelin involve the functional inhibition of Hsp90.