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The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study

BackgroundSeveral methods exist to cost hospital contacts when estimating the cost effectiveness of a new intervention. However, the implications of choosing a particular approach remain unclear. We compare the use of the three main diagnosis-related group (DRG)-based national unit costs in England to determine whether choice of approach can impact on economic evaluation results...

The cost-effectiveness of early care by dedicated teams for chronic mental health conditions: results from the Oxford-CLAHRC on Early Intervention Psychosis services in England

Introduction: Psychosis is a common and severe mental illness, with a large health and economic impact on societies worldwide. The earlier the illness is treated the better the long term outcomes. In England, Early Intervention in Psychosis (EIP) services have been introduced over the last 15 years to address this problem and they are included in the new Access and Waiting time...

Massive sequencing of 70 genes reveals a myriad of missing genes or mechanisms to be uncovered in hereditary spastic paraplegias

Hereditary spastic paraplegias (HSP) are neurodegenerative disorders characterized by lower limb spasticity and weakness that can be complicated by other neurological or non-neurological signs. Despite a high genetic heterogeneity (>60 causative genes), 40–70% of the families remain without a molecular diagnosis. Analysis of one of the pioneer cohorts of 193 HSP families...

Prevalencia de patología ano-rectal en pacientes portadores de VIH/SIDA

Muñoz C., Juan Andrés Mansilla E., Claudia Heider C., M. José Leal W. y Carolina Chain A. Universidad de La Frontera. Temuco, Chile. Departamento de Cirugía (CMC, JAME, CHC, MJLW). Hospital Doctor

PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot–Marie–Tooth disease

Charcot–Marie–Tooth disease (CMT) comprises a clinically and genetically heterogeneous group of peripheral neuropathies characterized by progressive distal muscle weakness and atrophy, foot deformities and distal sensory loss. Following the analysis of two consanguineous families affected by a medium to late-onset recessive form of intermediate CMT, we identified overlapping...

Are neuropsychological changes relevant in subclinical hypothyroidism?

AlmeidaI; Mario VaismanI; Antonio José Leal CostaII; Fabiola A.A. ReisIII; Vaneska ReutersIV; Patricia TeixeiraIV; Marcia FerreiraIV; Letícia B.B. de M. TeixeiraIII; Glória R.B. de AraújoV; Marco Antonio

Avaliação clínica e de sintomas psiquiátricos no hipotireoidismo subclínico

    Patrícia de Fátima dos Santos Teixeira*; Vaneska Spinelli Reuters; Cloyra Paiva Almeida; Márcia Martins Ferreira; Márcia Branco Wagman; Fabíola Alves Aarão Reis; Antonio José Leal Costa; Mário Vaisman