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Total brachial artery reactivity and first time incident coronary heart disease events in a longitudinal cohort study: The multi-ethnic study of atherosclerosis

investigators and institutions can be found at http://www. mesa-nhlbi.org. Author Contributions Data curation: Joseph F. Polak. Formal analysis: Joseph F. Polak. Funding acquisition: Joseph F. Polak ... . Conceptualization: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Investigation: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Methodology: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Project

Lipoprotein-Associated Phospholipase A2, a Novel Cardiovascular Inflammatory Marker, in HIV-Infected Patients

Background. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an emerging biomarker of cardiovascular disease. This study was conducted to describe the distribution of Lp-PLA2 in a cohort of human immunodeficiency virus (HIV)–infected adults and to determine associations between Lp-PLA2, cardiometabolic risk factors, and subclinical atherosclerosis in this population. Methods...

Cost-Effectiveness of Coronary Artery Calcium Testing for Coronary Heart and Cardiovascular Disease Risk Prediction to Guide Statin Allocation: The Multi-Ethnic Study of Atherosclerosis (MESA)

Background The Multi-Ethnic Study of Atherosclerosis (MESA) showed that the addition of coronary artery calcium (CAC) to traditional risk factors improves risk classification, particularly in intermediate risk asymptomatic patients with LDL cholesterol levels <160 mg/dL. However, the cost-effectiveness of incorporating CAC into treatment decision rules has yet to be clearly...

Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study

Background The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters with atherosclerosis are limited. Here, we assessed that relation. Methods Individual participant data from 14 cohorts, involving 59,025 individuals were used...

Particulate matter components and subclinical atherosclerosis: common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study

Background Concentrations of outdoor fine particulate matter (PM2.5) have been associated with cardiovascular disease. PM2.5 chemical composition may be responsible for effects of exposure to PM2.5. Methods Using data from the Multi-Ethnic Study of Atherosclerosis (MESA) collected in 2000–2002 on 6,256 US adults without clinical cardiovascular disease in six U.S. metropolitan...

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

: Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Hung-Ju Lin, Stela McLachlan, Kimmo Ronkainen, Ulf Schminke, Lars Lind, Coen D. A. Stehouwer, Peter Willeit, Joseph F. Polak

Fine Particulate Air Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study from the Multi-Ethnic Study of Atherosclerosis and Air Pollution

In a prospective cohort study, Sara Adar and colleagues find that decreasing levels of fine particulate matter in multiple US urban areas are associated with slowed progression of intima-medial thickness, a surrogate measure of atherosclerosis.

Sex Differences in Subclinical Atherosclerosis by Race/Ethnicity in the Multi-Ethnic Study of Atherosclerosis

Center, Houston, Texas (Jennifer A. Nettleton); Department of Radiology, Tufts-New England Medical Center, Boston, Massachusetts (Joseph F. Polak); Department of Medicine, Johns Hopkins University School

Association of Small Artery Elasticity With Incident Cardiovascular Disease in Older Adults: The Multi-Ethnic Study of Atherosclerosis

, Seattle, Washington (Lyndia C. Brumback, Richard A. Kronmal); Department of Radiology, Tufts Medical Center, Boston, Massachusetts (Joseph F. Polak); Division of Nephrology, Department of Medicine, UCSF

Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Joseph F. Polak Jye-Yu C. Backlund Patricia A. Cleary Anita P. Harrington Daniel H. O'Leary John M. Lachin David M. Nathan for the DCCT/EDIC Research Group OBJECTIVEThis study investigated the long

Metabolic Syndrome and Subclinical Atherosclerosis in Patients Infected with HIV

Background.The present study examines the association between carotid and coronary atherosclerosis and metabolic syndrome in human immunodeficiency virus (HIV)–infected adults. Methods.We measured the common and internal carotid intima-media thickness (c-IMT) using B-mode ultrasonography, and we measured coronary artery calcium (CAC) using high-resolution, electrocardiographic...

Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events

Background Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with...

Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study

Introduction Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study. Methods Over 100,000 single nucleotide polymorphisms (SNPs) were genotyped (Human...

Diabetic Cardiomyopathy and Subclinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis (MESA)

OBJECTIVE—Studies have demonstrated increased left ventricular mass (LVM) and diastolic dysfunction among diabetic patients without clinical cardiovascular disease (CVD), but few have assessed the potential contribution of subclinical CVD to ventricular abnormalities in diabetes. We examined whether diabetic cardiomyopathy is associated with subclinical atherosclerosis and if...

Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes

Erik Ingelsson Lisa M. Sullivan Joanne M. Murabito Caroline S. Fox Emelia J. Benjamin Joseph F. Polak James B. Meigs Michelle J. Keyes Christopher J. O'Donnell Thomas J. Wang Ralph B. D'Agostino Sr

Genetics of coronary artery calcification among African Americans, a meta-analysis

Background Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...

Association of Fibrinogen and Coagulation Factors Vll and VIII with Cardiovascular Risk Factors in the Elderly: The Cardiovascular Health Study

Webb; Ultrasound Reading Center—Geisinger Medical Center, Danville, PA: Dr. Daniel H. O'Leary, Dr. Joseph F. Polak, and Laurie Funk; Central Blood Analysis Laboratory—University of Vermont, Burlington