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Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica

, Republic of Korea 1 Research Foundation of Korea, Grant recipient: Ju Young Lee, Grant number: NRF- 2016M3A6A8928386 (the Intelligent Synthetic Biology Center of Global Frontier Project), and Ministry of ... . Acknowledgments We thank Dr. Young Hye Kim (KBSI) for the ESI MS analysis. Author Contributions Conceptualization: Ju Young Lee. Investigation: In-Seung Jang, Ji Yeon Jang, Jonggeon Jegal. Methodology: Ju

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

Neuroinflammation is associated with neurodegenerative diseases, including Alzheimer’s disease (AD). Thus, modulating the neuroinflammatory response represents a potential therapeutic strategy for treating neurodegenerative diseases. Several recent studies have shown that dopamine (DA) and its receptors are expressed in immune cells and are involved in the neuroinflammatory...

Factors associated with group bullying and psychopathology in elementary school students using child-welfare facilities

Sung Hwan Song,5 Ga Na Park,6 Ju Young Lee,1 Jae Ock Kim5 1Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, College of Medicine, Seoul National University, Seoul, South Korea

Improved spatial learning and memory by perilla diet is correlated with immunoreactivities to neurofilament and α-synuclein in hilus of dentate gyrus

-Young Lee Yeong Keun Yeo Jong Sang Kim Jinkyu Lim 0 Equal contributors Major in Food Biomaterials, Kyungpook National University , Daegu 702-701 , South Korea Background: Perilla (Perilla frutescens

Human DJ-1 and its homologs are novel glyoxalases

Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione. Purified DJ-1 proteins exhibit...

The validity of the canadian triage and acuity scale in predicting resource utilization and the need for immediate life-saving interventions in elderly emergency department patients

We evaluated the validity of the Canadian Triage and Acuity Scale (CTAS) in elderly emergency department (ED) patients. In particular, we examined the sensitivity and specificity of the CTAS for identifying elderly patients who received an immediate life-saving intervention in the ED. We reviewed the medical records of consecutive patients who were 65 years of age or older and...

Preparation and Characterization of Self-Emulsified Docetaxel

The aim of this paper was to prepare a self-microemulsifying docetaxel (Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx-loaded self-microemulsifying system (SMES) showed the initial size of the range of 80–100 nm with narrow size distribution and the negative zeta-potential values. Its morphology was a spherical shape by atomic force microscopy. In...

Preparation and Characterization of Self-Emulsified Docetaxel

The aim of this paper was to prepare a self-microemulsifying docetaxel (Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx-loaded self-microemulsifying system (SMES) showed the initial size of the range of 80–100 nm with narrow size distribution and the negative zeta-potential values. Its morphology was a spherical shape by atomic force microscopy. In...

Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli

Now that many genomes have been sequenced and the products of newly identified genes have been annotated, the next goal is to engineer the desired phenotypes in organisms of interest. For the phenotypic engineering of microorganisms, we have developed novel artificial transcription factors (ATFs) capable of reprogramming innate gene expression circuits in Escherichia coli. These...

The Incidence of Tuberculosis after a Measles Outbreak

Among 53,974 cases of measles that occurred during the 2000–2001 outbreak in Korea, the incidence of tuberculosis following measles was 47 cases per 214,949.6 person-years, which was significantly lower than that in the general population (standardized incidence ratio, 0.73; 95% confidence interval, 0.54–0.96). In conclusion, we did not find a positive relationship between...