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34 papers found.
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RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

The oncogene Bmi-1 is a member of the Polycomb group gene family. Its expression is found to be greatly increased in a number of malignant tumors including breast cancer. This could suggest Bmi-1 as a potent therapeutic target. In this study, RNAi was introduced to down-regulate the expression of Bmi-1 in a highly malignant breast adenocarcinoma cell line, MCF-7. A thorough study...

Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations

Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different groups have different drug sensitivities and, consequently, there are differences in drug effects. In this study, we...

Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis

Medical College, Beijing, 100021, ChinaChan-juan Cui, Guo-jing Wang, Sheng-kai Huang & Wei CuiDepartment of Laboratory Medicine, Peking University Third Hospital, Haidian District, Beijing, 100191 ... , ChinaShuo Yang & Rui Qiao AuthorsSearch for Chan-juan Cui in:Nature Research journals • PubMed • Google Scholar Search for Guo-jing Wang in:Nature Research journals • PubMed • Google Scholar Search for Shuo

Dynamic and Modularized MicroRNA Regulation and Its Implication in Human Cancers

• Google Scholar Search for Juan Cui in:Nature Research journals • PubMed • Google Scholar Contributions J.S. and J.C. conceived and designed the experiments; J.S., B.S., Z.X., and T.G. performed the ... . Corresponding author Correspondence to Juan Cui. Electronic supplementary material miRDR codeSupplementary InformationSupplementary Table S2Supplementary Table S4Supplementary Table S5Supplementary Table

Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation

MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Compelling evidences of microRNAs from rice, milk, and honeysuckle transported to human blood and tissues have created a high volume of interests in the fundamental questions...

Effect of Straw Amendment on Soil Zn Availability and Ageing of Exogenous Water-Soluble Zn Applied to Calcareous Soil

Organic matter plays a key role in availability and transformation of soil Zn (zinc), which greatly controls Zn concentrations in cereal grains and human Zn nutrition level. Accordingly, soils homogenized with the wheat straw (0, 12 g straw kg-1) and Zn fertilizer (0, 7 mg Zn kg-1) were buried and incubated in the field over 210 days to explore the response of soil Zn...

Dietary MicroRNA Database (DMD): An Archive Database and Analytic Tool for Food-Borne microRNAs

With the advent of high throughput technology, a huge amount of microRNA information has been added to the growing body of knowledge for non-coding RNAs. Here we present the Dietary MicroRNA Databases (DMD), the first repository for archiving and analyzing the published and novel microRNAs discovered in dietary resources. Currently there are fifteen types of dietary species, such...

Corrigendum: Hinge-like structure induced unusual properties of black phosphorus and new strategies to improve the thermoelectric performance

Sheng-YingYue Hui-Juan Cui Qing- Rong Zheng Gang Su This Article contains errors in the insets of Figures 3(a), 3(b) and 3(c), where the stress values were incorrectly given as three times smaller than

Highly efficient light management for perovskite solar cells

of the Chinese Academy of Sciences. Author information AffiliationsSchool of Physics, University of Chinese Academy of Sciences, P. O. Box 4588, Beijing 100049, ChinaDong-Lin Wang, Hui-Juan Cui ... ScholarSearch for Hui-Juan Cui in:Nature Research journals • PubMed • Google ScholarSearch for Guo-Jiao Hou in:Nature Research journals • PubMed • Google ScholarSearch for Zhen-Gang Zhu in:Nature Research

Tinselenidene: a Two-dimensional Auxetic Material with Ultralow Lattice Thermal Conductivity and Ultrahigh Hole Mobility

Sciences, University of Chinese Academy of Sciences, Beijing, China 100049Wu-Zhang Fang, Hui-Juan Cui, Qing-Rong Zheng & Gang Su AuthorsSearch for Li-Chuan Zhang in:Nature Research journals • PubMed • Google ... ScholarSearch for Guangzhao Qin in:Nature Research journals • PubMed • Google ScholarSearch for Wu-Zhang Fang in:Nature Research journals • PubMed • Google ScholarSearch for Hui-Juan Cui in:Nature Research

Computational Prediction of Human Salivary Proteins from Blood Circulation and Application to Diagnostic Biomarker Identification

Proteins can move from blood circulation into salivary glands through active transportation, passive diffusion or ultrafiltration, some of which are then released into saliva and hence can potentially serve as biomarkers for diseases if accurately identified. We present a novel computational method for predicting salivary proteins that come from circulation. The basis for the...

Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in cancer cells, which tri mechanisms to transport them out, hence leading to increased acidity in their extracellular environments. It has been well established that the increased acidity will induce cell death of normal cells but not cancer cells. The main question we address here is: how...

Reconsideration of In-Silico siRNA Design Based on Feature Selection: A Cross-Platform Data Integration Perspective

RNA interference via exogenous short interference RNAs (siRNA) is increasingly more widely employed as a tool in gene function studies, drug target discovery and disease treatment. Currently there is a strong need for rational siRNA design to achieve more reliable and specific gene silencing; and to keep up with the increasing needs for a wider range of applications. While...

The Arabidopsis LFR Gene Is Required for the Formation of Anther Cell Layers and Normal Expression of Key Regulatory Genes

The anther is the male reproductive organ in flowering plants. Although some genes were reported to be involved in anther development, the molecular mechanisms underlying the transcriptional regulation of these genes is unclear. lfr-2 (leaf and flower related-2), the null allele of Arabidopsis thaliana LFR (LEAF AND FLOWER RELATED), was male-sterile. The anthers of lfr-2 plants...

The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats

Zhang,1 Yu-juan Cui,1 Yu-mei Chang,1 Cai-wu Jiang,2 Zhen-zhi Meng,3 Peng Xu,1 Hai-yan Liu,1 Dong-ying Wang,1 and Xue-bin Cao1 1Department of Cardiology, Geriatric Cardiovascular Disease Research and

MicroRNA Expression and Regulation in Human Ovarian Carcinoma Cells by Luteinizing Hormone

Background MicroRNAs have been widely-studied with regard to their aberrant expression and high correlation with tumorigenesis and progression in various solid tumors. With the major goal of assessing gonadotropin (luteinizing hormone, LH) contributions to LH receptor (LHR)-positive ovarian cancer cells, we have conducted a genome-wide transcriptomic analysis on human epithelial...

A phylogenetic model for understanding the effect of gene duplication on cancer progression

As biotechnology advances rapidly, a tremendous amount of cancer genetic data has become available, providing an unprecedented opportunity for understanding the genetic mechanisms of cancer. To understand the effects of duplications and deletions on cancer progression, two genomes (normal and tumor) were sequenced from each of five stomach cancer patients in different stages (I...

A Comparative Study of Gene-Expression Data of Basal Cell Carcinoma and Melanoma Reveals New Insights about the Two Cancers

A comparative analysis of genome-scale transcriptomic data of two types of skin cancers, melanoma and basal cell carcinoma in comparison with other cancer types, was conducted with the aim of identifying key regulatory factors that either cause or contribute to the aggressiveness of melanoma, while basal cell carcinoma generally remains a mild disease. Multiple cancer-related...

In-silico prediction of blood-secretory human proteins using a ranking algorithm

Background Computational identification of blood-secretory proteins, especially proteins with differentially expressed genes in diseased tissues, can provide highly useful information in linking transcriptomic data to proteomic studies for targeted disease biomarker discovery in serum. Results A new algorithm for prediction of blood-secretory proteins is presented using an...