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Search: authors:"Jun K. Takeuchi"

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Chromatin Modification and Remodeling in Heart Development

In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have...

Chromatin Modification and Remodeling in Heart Development

In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have...

Sexual dimorphisms of mRNA and miRNA in human/murine heart disease

Background Sexual dimorphisms are well recognized in various cardiac diseases such as ischemic cardiomyopathy (ICM), hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Thorough understanding of the underlying genetic programs is crucial to optimize treatment strategies specified for each gender. By performing meta-analysis and microarray analysis, we sought to...

NKX2-5 Regulates the Expression of β-Catenin and GATA4 in Ventricular Myocytes

Background The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and β-catenin. The interplay between these factors and their downstream targets are not completely understood. Here, we studied regulation of β-catenin and GATA4 by NKX2-5 in human fetal cardiac myocytes...

Reptilian heart development and the molecular basis of cardiac chamber evolution

. Georges Stephany Latham Laurel Beck R. Mark Henkelman Brian L. Black Eric N. Olson Juli Wade Jun K. Takeuchi Mona Nemer Scott F. Gilbert Benoit G. Bruneau - CORRIGENDUM In this Letter, author Laurel Beck

Chromatin remodelling complex dosage modulates transcription factor function in heart development

K. Takeuchi in:Nature Research journals • PubMed • Google ScholarSearch for Xin Lou in:Nature Research journals • PubMed • Google ScholarSearch for Jeffrey M. Alexander in:Nature Research journals ... Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.Ian C. ScottDepartment of Pediatrics, University of California, San Francisco, California 94143, USA.Benoit G. Bruneau AuthorsSearch for Jun