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Pre-clinical Experimental Therapeutics and Pharmacology

BACKGROUND: Hypoxia-inducible factor 1a (HIF-1alpha) induces transcription of glycolytic genes, including carbonic anhydrase IX (CA IX) and glucose transporter-1 (GLUT-1), and angiogenic proteins like vascular endothelial growth factor (VEGF). HIF-1alpha expression is increased in human glioblastoma multiforme (GBM) compared to low-grade tumors. We have previously shown that HIF...

Stem Cells

increase the efficacy of radiotherapy. SC-27. MOLECULAR AND LINEAGE CHARACTERIZATION OF GLIOMA STEM CELLS Jun Fu , Rui-Jun Shen , Howard Colman , Frederick F. Lang , W. K. Alfred Yung , and Dimpy Koul ; The

Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration

While studying Bim, a BH3-only proapoptotic protein, we identified an ∼36 kDa protein, which was abundantly expressed in all five strains of primary normal human prostate (NHP) epithelial cells but significantly reduced or lost in seven prostate cancer cell lines. The ∼36 kDa protein was subsequently identified as annexin II by proteomic approach and confirmed by Western blotting...

Fine Mapping of the Psoriasis Susceptibility Locus PSORS1 Supports HLA-C as the Susceptibility Gene in the Han Chinese Population

PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population. In this...

Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats—association with oxidative DNA damage and enhanced cell proliferation

Arsenic is a notorious environmental toxicant known to be carcinogenic for the skin, lung and urinary bladder in human beings. The carcinogenicity of trimethylarsine oxide (TMAO), one organic metabolite of inorganic arsenics in humans and experimental animals, was investigated here in male Fischer 344 rats in a 2-year carcinogenicity test. TMAO was administered to a total of 129...

Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression

Our recent research indicated that phenobarbital (PB) may inhibit the development of N-diethylnitrosamine (DEN)-initiated pre-neoplastic lesions at low doses in a rat liver medium-term bioassay (Ito test), while high doses exhibit promoting activity. This raises the question of whether treatment with low doses of PB might reduce cancer risk. For clarification, male 6-week-old...

Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells

research; Guo-hai SHI, Xu-dong YAO, Shi-ling ZHANG, Bo DAI, and Wen-jun XIAO performed the research; Hai-liang ZHANG and Yi-jun SHEN contributed analytic tools; Guo-hai SHI, Yao ZHU, and Yi-ping ZHU analyzed ... Ye, Xu-dong Yao, Shi-ling Zhang, Bo Dai, Hai-liang Zhang, Yi-jun Shen, Yao Zhu, Yi-ping Zhu, Wen-jun Xiao & Chun-guang MaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai

Plasma microRNAs as potential biomarkers for non-small-cell lung cancer

L Katz AuthorsSearch for Jun Shen in:Nature Research journals • PubMed • Google ScholarSearch for Nevins W Todd in:Nature Research journals • PubMed • Google ScholarSearch for Howard Zhang in:Nature

α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells

Aim:We aimed to investigate the potential modification of previously unrecognized surface glycoprotein(s) by α2,6-sialylation other than by integrins.Methods:The expression of β-galactoside α2,6-sialyltransferase (ST6Gal-I) in the colon cancer cell line HCT116 was reduced by siRNA. The adhesion and Boyden chamber assay were used to detect the variation in cell motility. α2,6...

The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus

Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, resulting in inhibition of nuclear translocation of nuclear factor of activated T-cells (NFAT). There is increasing data supporting a critical role of NFAT in mediating angiogenic responses stimulated...

Fetal Onset of Aberrant Gene Expression Relevant to Pulmonary Carcinogenesis in Lung Adenocarcinoma Development Induced by In Utero Arsenic Exposure

Arsenic is a human pulmonary carcinogen. Our work indicates that in utero arsenic exposure in mice can induce or initiate lung cancer in female offspring. To define early molecular changes, pregnant C3H mice were given 85 ppm arsenic in drinking water from days 8 to 18 of gestation and expression of selected genes in the fetal lung or in lung tumors developing in adults was...

Peach genetic resources: diversity, population structure and linkage disequilibrium

Background Peach (Prunus persica (L.) Batsch) is one of the most important model fruits in the Rosaceae family. Native to the west of China, where peach has been domesticated for more than 4,000 years, its cultivation spread from China to Persia, Mediterranean countries and to America. Chinese peach has had a major impact on international peach breeding programs due to its high...

Peach genetic resources: diversity, population structure and linkage disequilibrium

Peach (Prunus persica (L.) Batsch) is one of the most important model fruits in the Rosaceae family. Native to the west of China, where peach has been domesticated for more than 4,000 years, its cultivation spread from China to Persia, Mediterranean countries and to America. Chinese peach has had a major impact on international peach breeding programs due to its high genetic...

Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers

Background Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma microRNAs are useful in identifying lung cancer among individuals with CT-detected SPNs. Methods By using...

The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies

Background Numerous studies have investigated association of OGG1 Ser326Cys polymorphism with lung cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis based on 27 publications encompass 9663 cases and 11348 controls to comprehensively evaluate such associations. Methods We searched publications from MEDLINE and EMBASE which were...

Gene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray

Osteoarthritis (OA) is a degenerative joint disease that affects both cartilage and bone. A better understanding of the early molecular changes in subchondral bone may help elucidate the pathogenesis of OA. We used microarray technology to investigate the time course of molecular changes in the subchondral bone in the early stages of experimental osteoarthritis in a rat model. We...

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

Birgit H. Funke Matthew S. Lebo Samantha B. Baxter Jun Shen Heather M. McLaughlin Eugene H. Clark 2 Larry J. Babb Stephanie W. Cox Steven R. DePalma Carolyn Y. Ho J.G. Seidman Christine E. Seidman Heidi L

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Background Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could...

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could be...