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Detecting virus-specific effects on post-infection temporal gene expression

Different types of viruses have different envelope proteins, and may have their shared or distinctive host-virus interactions which result in various post-infection effects in humans and animals. These effects often do not appear at once but take time to unfold. To characterize the virus-specific effects, we applied a Multivariate Polynomial Time-dependent Genetic Association...

Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1)

Peritoneal fibrosis remains a serious complication of long-term peritoneal dialysis (PD) leading to peritoneal membrane ultrafiltration failure. Epithelial–mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a key process of peritoneal fibrosis. Curcumin has been previously shown to inhibit EMT of renal tubular epithelial cells and prevent renal fibrosis. There...

Pralatrexate in Chinese Patients with Relapsed or Refractory Peripheral T-cell Lymphoma: A Single-arm, Multicenter Study

Mundipharma (China) Pharmaceutical Co., Ltd. Xiaonan Hong, Yuqin Song, Huiqiang Huang, Bing Bai, Huilai Zhang, Xiaoyan Ke, Yuankai Shi, and Jun Zhu declare that they have no conflicts of interest that might be

Postnatal growth in preterm infants during the first year of life: A population-based cohort study in China

. Shengtao Zhou for his effort in manuscript conception and design. Author Contributions Conceptualization: Leni Kang, Huiqing Wang, Chunhua He, Ke Wang, Lei Miao, Yanping Wang, Jun Zhu, Xiaohong Li, Dezhi ... Mu. Data curation: Leni Kang, Chunhua He, Lei Miao, Qi Li, Yanping Wang, Jun Zhu. Formal analysis: Leni Kang, Xiaohong Li, Xingzhe Liu. 9 / 11 Funding acquisition: Huiqing Wang, Yanping Wang

High-dose etoposide could discriminate the benefit from autologous peripheral blood stem cell transplantation in the patients with refractory diffuse large B cell lymphoma

To evaluate the strategy of using high-dose etoposide mobilization followed by autologous peripheral blood stem cell transplantation (APBSCT) in patients with diffuse large B cell lymphoma (DLBCL) refractory to rituximab-based chemotherapy. Forty patients with refractory DLBCL were treated with high-dose etoposide for stem cell mobilization. All patients were in progressive...

Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer

Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer Yong Wu,1,2 Yu Deng,2,3 Jun Zhu,1,2 Yachen Duan,1,2 WeiWei Weng,2,3 Xiaohua Wu1,2 1Department of

Laser Spot Center Detection and Comparison Test

High efficiency and precision of the pot center detection are the foundations of avionics instrument navigation and optics measurement basis for many applications. It has noticeable impact on overall system performance. Among them, laser spot detection is very important in the optical measurement technology. In order to improve the low accuracy of the spot center position, the...

Analysis of the Load Sharing Behaviour and Cushion Failure Mode for a Disconnected Piled Raft

Disconnected piled raft (DPR) foundations are characterized by having no structural connection to a raft. The raft-pile gap is filled with a granular cushion, which creates a more uniform pressure distribution on the raft and reduces the differential settlement. A series of tests has been performed to investigate the load transfer mechanisms of a DPR. The effects of the thickness...

Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1

OBJECTIVEThrough dynamic means, etiological factors, including chronic inflammation and insulin resistance have the potential to perpetuate metabolic incidences such as type 2 diabetes and obesity. Abatement of such syndromes can be achieved by complex mechanisms initiated through bioactive compounds such as polyphenols derived from fruits. Using a whole-fruit approach, the...

An isolable catenane consisting of two Möbius conjugated nanohoops

Besides its mathematical importance, the Möbius topology (twisted, single-sided strip) is intriguing at the molecular level, as it features structural elegance and distinct properties; however, it carries synthetic challenges. Although some Möbius-type molecules have been isolated by synthetic chemists accompanied by extensive computational studies, the design, preparation, and...

The relationship between preoperative psychological evaluation and compensatory sweating

, Yan-Jun Zhu†1, Jie Liu†1, Li-Wei Li2 and Ying-Hui Liu1 †Contributed equally Journal of Cardiothoracic Surgery201813:42 ©  The Author(s). 2018 Received ... -Yu Wang and Yan-Jun Zhu contributed equally to this work. Abbreviations CS:  Compensatory sweating EPQ:  Eysenck Personality Questionnaire PPH:  Primary palmar hyperhidrosis SAS:  Self

Dissection and fine-mapping of two QTL for grain size linked in a 460-kb region on chromosome 1 of rice

BackgroundGrain size is a key determinant of grain weight and a trait having critical influence on grain quality in rice. While increasing evidences are shown for the importance of minor-effect QTL in controlling complex traits, the attention has not been given to grain size until recently. In previous studies, five QTL having small effects for grain size were resolved on the...

The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China

Shan Xiao,1 Jun Zhu,1 and Hua Yao2,4 1Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China 2Postdoctoral Research Station of Public Health, School of ... Zhang and Jiangfeng Mao worked on the formal analysis. Mingchen Zhang acquired the funding of the study. Mingchen Zhang, Ablikm Tuerdi, Xiaoyun Zeng, Li Quan, Jun Zhu, and Shan Xiao are assigned in the

Identification of microR-106b as a prognostic biomarker of p53-like bladder cancers by ActMiR

Centre for the Unknown, Lisbon, PortugalMireia Castillo-MartinThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAYixuan Gong, William K. Oh, Matthew D. Galsky & Jun Zhu ... journals • PubMed • Google Scholar Search for Jun Zhu in:Nature Research journals • PubMed • Google Scholar Conflict of interest The authors declare that they have no conflict of interest

Associations between the Epithelial-Mesenchymal Transition Phenotypes of Circulating Tumor Cells and the Clinicopathological Features of Patients with Colorectal Cancer

’ Contributions Fengjie Wu and Jun Zhu collected the clinical data and performed the histological analysis. Yongjiang Mao and Xiaomei Li performed the statistical analysis of case data and imaging data. Baoguang Hu

Large Lateral Photovoltaic Effect in MoS2/GaAs Heterojunction

Molybdenum disulfide (MoS2) nanoscaled films are deposited on GaAs substrates via magnetron sputtering technique, and MoS2/GaAs heterojunctions are fabricated. The lateral photovoltaic effect (LPE) of the fabricated MoS2/GaAs heterojunctions is investigated. The results show that a large LPE can be obtained in the MoS2/n-GaAs heterojunction. The LPE exhibits a linear dependence...

Analysis of the genotype-phenotype correlation in patients with phenylketonuria in mainland China

University Hospital, Sichuan University, Chengdu, ChinaNana Li, Chunhua He, Jing Tao, Zhen Liu, Jun Zhu, Ying Deng, Yixiong Guo, Ping Yu & Yanping WangKey Laboratory of Birth Defects and Related Diseases of ... Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaNana Li, Chunhua He, Jing Tao, Zhen Liu, Jun Zhu, Ying Deng, Yixiong Guo, Qintong Li, Ping Yu & Yanping WangLaboratory of

Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture

Most of the genome-wide association studies (GWASs) for human complex diseases have ignored dominance, epistasis and ethnic interactions. We conducted comparative GWASs for total cholesterol using full model and additive models, which illustrate the impacts of the ignoring genetic variants on analysis results and demonstrate how genetic effects of multiple loci could differ...

Spectral reconstruction of signals from periodic nonuniform subsampling based on a Nyquist folding scheme

Periodic nonuniform sampling occurs in many applications, and the Nyquist folding receiver (NYFR) is an efficient, low complexity, and broadband spectrum sensing architecture. In this paper, we first derive that the radio frequency (RF) sample clock function of NYFR is periodic nonuniform. Then, the classical results of periodic nonuniform sampling are applied to NYFR. We extend...

Highly Enhanced H2 Sensing Performance of Few-Layer MoS2/SiO2/Si Heterojunctions by Surface Decoration of Pd Nanoparticles

A novel few-layer MoS2/SiO2/Si heterojunction is fabricated via DC magnetron sputtering technique, and Pd nanoparticles are further synthesized on the device surface. The results demonstrate that the fabricated sensor exhibits highly enhanced responses to H2 at room temperature due to the decoration of Pd nanoparticles. For example, the Pd-decorated MoS2/SiO2/Si heterojunction...