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Search: authors:"Justin J. J. van der Hooft"

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A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters

ObjectivePlants produce a plethora of specialized metabolites to defend themselves against pathogens and insects, to attract pollinators and to communicate with other organisms. Many of these are also applied in the clinic and in agriculture. Genes encoding the enzymes that drive the biosynthesis of these metabolites are sometimes physically grouped on the chromosome, in regions...

Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose

IntroductionCampylobacter jejuni is the leading cause of foodborne bacterial enteritis in humans, and yet little is known in regard to how genetic diversity and metabolic capabilities among isolates affect their metabolic phenotype and pathogenicity.ObjectivesFor instance, the C. jejuni 11168 strain can utilize both l-fucose and l-glutamate as a carbon source, which provides the...

Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation

, UK 1 Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow , UK 2 & Justin J. J. van der Hooft 3 Wellcome Trust Centre for Molecular Parasitology ... grant to the Wellcome Trust Centre for Molecular Parasitology (Grant No. 104111/Z/14/Z). Compliance with ethical standards Conflict of interest Justin J. J. van der Hooft declares that he has no conflict