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An Analysis of 3-Year Outcomes Following Canaloplasty for the Treatment of Open-Angle Glaucoma

Purpose. To report 3-year results investigating the safety and efficacy of canaloplasty for open-angle glaucoma. Setting. University of Oklahoma, Dean McGee Eye Institute, Oklahoma, United States of America. Design. Nonrandomized single-center retrospective chart review. Methods. Adult open-angle glaucoma eyes underwent canaloplasty or combined cataract-canaloplasty surgery. A...

An Analysis of 3-Year Outcomes Following Canaloplasty for the Treatment of Open-Angle Glaucoma

Purpose. To report 3-year results investigating the safety and efficacy of canaloplasty for open-angle glaucoma. Setting. University of Oklahoma, Dean McGee Eye Institute, Oklahoma, United States of America. Design. Nonrandomized single-center retrospective chart review. Methods. Adult open-angle glaucoma eyes underwent canaloplasty or combined cataract-canaloplasty surgery. A...

Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner

agreement between OUHSC and Qualyst Transporter Solutions, LLC (Durham, NC). 22 / 26 Author Contributions Conceptualization: Khondoker Alam, Kai Ding, Wei Yue. Data curation: Khondoker Alam, Taleah Farasyn ... , Alexandra Crowe, Kai Ding, Wei Yue. Formal analysis: Khondoker Alam, Taleah Farasyn, Alexandra Crowe, Kai Ding, Wei Yue. Funding acquisition: Wei Yue. Investigation: Khondoker Alam, Taleah Farasyn, Alexandra

Temperature Dependence of Raman-Active In-Plane E2g Phonons in Layered Graphene and h-BN Flakes

Thermal properties of sp2 systems such as graphene and hexagonal boron nitride (h-BN) have attracted significant attention because of both systems being excellent thermal conductors. This research reports micro-Raman measurements on the in-plane E2g optical phonon peaks (~ 1580 cm−1 in graphene layers and ~ 1362 cm−1 in h-BN layers) as a function of temperature from − 194 to 200...

PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. In this study, we aimed to explore the role of PKM2 in the activation of mDCs in...

PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure is mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on dendritic cells in immune-mediated diseases. In this study, we aimed to explore the role of PKM2 in the activation of mDCs in...

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs, and various inhibitors have been reported in the literature. However, none of the reported potent inhibitors of human mPGES-1 has shown to be also a potent inhibitor of mouse or rat mPGES-1, which prevents using...

MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma

MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma Zhi-Wei Lu,1,2,* Ming-Yu Du,2,* Lu-Xi Qian,1,2 Nan Zhang,2 Jia-Jia Gu,2 Kai Ding,3 Jing Wu,2 Hong-Ming

Identification and characterization of inorganic-phosphate-solubilizing bacteria from agricultural fields with a rapid isolation method

The ability to solubilize fixed inorganic phosphorus (P) for plant growth is important for increasing crop yield. More P can be released by inoculating soil with inorganic-phosphate-solubilizing bacteria (iPSBs). We used 96-well microplates instead of traditional 200-mm petri dishes to rapidly screen iPSB strains for their solubilizing ability. We simultaneously obtained 76 iPSB...

Fractal Dimension Based on Morphological Covering for Ground Target Classification

Seismic waves are widely used in ground target classification due to its inherent characteristics. However, they are often affected by extraneous factors and have been found to demonstrate a complicated nonlinear characteristic. The traditional signal analysis methods cannot effectively extract the nonlinear features. Motivated by this fact, this paper applies the fractal...

Fractal Dimension Based on Morphological Covering for Ground Target Classification

Seismic waves are widely used in ground target classification due to its inherent characteristics. However, they are often affected by extraneous factors and have been found to demonstrate a complicated nonlinear characteristic. The traditional signal analysis methods cannot effectively extract the nonlinear features. Motivated by this fact, this paper applies the fractal...

Long-term nitrogen fertilization decreased the abundance of inorganic phosphate solubilizing bacteria in an alkaline soil

Inorganic phosphate solubilizing bacteria (iPSB) are essential to facilitate phosphorus (P) mobilization in alkaline soil, however, the phylogenetic structure of iPSB communities remains poorly characterized. Thus, we use a reference iPSB database to analyze the distribution of iPSB communities based on 16S rRNA gene illumina sequencing. Additionally, a noval pqqC primer was...

Cetuximab and Cisplatin Show Different Combination Effect in Nasopharyngeal Carcinoma Cells Lines via Inactivation of EGFR/AKT Signaling Pathway

 Teng Huang,1,2,3 Kai Ding,2,3,4 Haixia Cao,3 Lin Xu,5 and Xia He1,2,3,4 1The Fourth Clinical School of Nanjing Medical University, Nanjing 210009, China 2Department of Radiation Oncology, Nanjing

MICU1 drives glycolysis and chemoresistance in ovarian cancer

ScholarSearch for Rosemary Zuna in:Nature Research journals • PubMed • Google ScholarSearch for Kai Ding in:Nature Research journals • PubMed • Google ScholarSearch for Leonidas Tsiokas in:Nature Research

MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis

Background Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant factor that limits the efficacy of radiotherapy for NPC patients. Growing evidence supports that microRNAs (miRNAs) play an important role in radiation response...

MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis

Background Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant factor that limits the efficacy of radiotherapy for NPC patients. Growing evidence supports that microRNAs (miRNAs) play an important role in radiation response...

On the Local and Stratified Likelihood Approaches in Single-Index Hazards Model

Kai Ding Michael R. Kosorok Donglin Zeng We propose the single-index hazards model for censored survival data. As an extension of the Cox model and many transformation models, this model allows

Improving Intensity-Based Lung CT Registration Accuracy Utilizing Vascular Information

Accurate pulmonary image registration is a challenging problem when the lungs have a deformation with large distance. In this work, we present a nonrigid volumetric registration algorithm to track lung motion between a pair of intrasubject CT images acquired at different inflation levels and introduce a new vesselness similarity cost that improves intensity-only registration...

Improving Intensity-Based Lung CT Registration Accuracy Utilizing Vascular Information

Accurate pulmonary image registration is a challenging problem when the lungs have a deformation with large distance. In this work, we present a nonrigid volumetric registration algorithm to track lung motion between a pair of intrasubject CT images acquired at different inflation levels and introduce a new vesselness similarity cost that improves intensity-only registration...

Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury

Gastrointestinal (GI) mucosal damage is a devastating adverse effect of radiation therapy. We have recently reported that expression of Dclk1, a Tuft cell and tumor stem cell (TSC) marker, 24h after high dose total-body gamma-IR (TBI) can be used as a surrogate marker for crypt survival. Dietary pectin has been demonstrated to possess chemopreventive properties, whereas its...