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Systems Biology and the Discovery of Diagnostic Biomarkers

Systems biology is an approach to the science that views biology as an information science, studies biological systems as a whole and their interactions with the environment. This approach, for the reasons described here, has particular power in the search for informative diagnostic biomarkers of diseases because it focuses on the fundamental causes and keys on the identification...

Microscopic Investigation of Rate Dependence on Three-Point Notched-Tip Bending Sandstone

The cracking process in rock or concrete is usually characterized by the formation of microcracks that eventually form a propagating macrocrack. A series of three-point bending experiments were performed on sandstone containing Mode I crack under different loading rates. The microscopic monitoring system was established to capture the cracking process at notch tip. The loading...

Range extension of the rare agamid, Pseudocalotes austeniana (Annandale, 1908) (Reptilia, Sauria, Draconinae) in the East Himalaya, with comments on its ontogenetic shift

013873 was collected by Ke JIANG and Kai WANG from 80K, Medog County, Tibet, China (29?39?39? N, 095?29?25? E, WGS 84) in August 2013 and TMNH 20170001 was collected by Ping CI, Shiyang WEN, and Weidong ... (Fig. 1). China: Tibet Autonomous Region: Nychi Prefecture: Medog County: 80K (29?39?39? N, 095?29?25? E, WGS 84), collected by Kai Wang, Ke Jiang, and Jing Che on August 10, 2013 (female, KIZ 013873

EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer

Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4–12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell lung carcinoma (NSCLC) represents a great unmet need. Preclinical models...

Urban heat island modelling of a tropical city: case of Kuala Lumpur

The steep increase in urban populations results in the spatial extent of cities expanding both horizontally and vertically. The climatic response of urban areas differs greatly to rural areas exposed to the same environmental conditions, with urban temperatures generally being higher, particularly in the late afternoon and evening. Coupled with the upward trend in global...

iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes

A range of rare and common genetic variants have been discovered to be potentially associated with mental diseases, but many more have not been uncovered. Powerful integrative methods are needed to systematically prioritize both variants and genes that confer susceptibility to mental diseases in personal genomes of individual patients and to facilitate the development of...

Emerging Technologies, Infrastructures, and Applications for Video Streaming over Future Communication Networks

not be possible without the participation of our expert reviewers, who provided valuable feedback and constructive comments throughout the review process. Yuanlong Cao Yuming Fang Jiyan Wu Wei Quan Kai ... Wang

Experimental Investigation of Vibration Characteristics in a Centrifugal Pump with Vaned Diffuser

addressed to Kai Wang; nc.ude.sju@iakgnaw Received 26 August 2018; Revised 17 November 2018; Accepted 3 December 2018; Published 24 December 2018 Academic Editor: Franck Poisson Copyright © 2018 Kai Wang

NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data

Recent advances in single-molecule sequencing techniques, such as Nanopore sequencing, improved read length, increased sequencing throughput, and enabled direct detection of DNA modifications through the analysis of raw signals. These DNA modifications include naturally occurring modifications such as DNA methylations, as well as modifications that are introduced by DNA damage or...

New Trigonometric Basis Possessing Denominator Shape Parameters

should be addressed to Kai Wang; moc.qq@844886616 Received 30 July 2018; Accepted 27 September 2018; Published 24 October 2018 Academic Editor: Nhon Nguyen-Thanh Copyright © 2018 Kai Wang and Guicang

Experimental investigation on True Triaxial Deformation and Progressive Damage Behaviour of Sandstone

experimental investigation on t rue t riaxial Deformation and progressive Damage Behaviour of sandstone Zhaolin Li Lianguo Wang Yinlong Lu Wenshuai Li Kai Wang Hao Fan studying the true triaxial ... Li, Lianguo Wang* and Yinlong Lu designed experiments; Zhaolin Li, Wenshuai Li, Kai Wang and Hao Fan carried out experiments; Zhaolin Li and Wenshuai Li analyzed experimental results; Zhaolin Li wrote

A meta-analysis of anti-interleukin-13 monoclonal antibodies for uncontrolled asthma

Conceptualization: Hang Li, Xiaohong Liu. Data curation: Hang Li, Kai Wang, Huiting Huang, Wenbin Cheng. Formal analysis: Hang Li, Kai Wang, Wenbin Cheng. Funding acquisition: Xiaohong Liu. Investigation: Hang Li ... , Wenbin Cheng. Methodology: Hang Li, Kai Wang, Wenbin Cheng. Project administration: Huiting Huang, Xiaohong Liu. Software: Hang Li. 10 / 13 Supervision: Huiting Huang, Xiaohong Liu. Validation: Hang Li

Global threshold dynamics of a stochastic epidemic model incorporating media coverage

In this paper, we investigate the global threshold dynamics of a stochastic SIS epidemic model incorporating media coverage. We give the basic reproduction number R 0 s $\mathcal{R}_{0}^{s}$ and establish a global threshold theorem by Feller’s test: if R 0 s ≤ 1 $\mathcal{R}_{0}^{s}\leq 1$ , the disease will die out a.s.; if R 0 s > 1 $\mathcal{R}_{0}^{s}>1$ , the disease will...

Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer

Yingeng Wang,1,2 Meijie Liao,1,2 Xiaojun Rong,1,2 Bin Li,1 Kai Wang,1 Jing Chen,1 and Hao Zhang1 1Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Yellow

An Efficient Algorithm to Test Forcibly-connectedness of Graphical Degree Sequences

We present an algorithm to test whether a given graphical degree sequence is forcibly connected or not and prove its correctness. We also outline the extensions of the algorithm to test whether a given graphical degree sequence is forcibly $k$-connected or not for every fixed $k\ge 2$. We show through experimental evaluations that the algorithm is efficient on average, though its...

Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1

Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) signaling pathway that some growth factors promoted the migration and proliferation of tumor cells. The aim of this study is to explore the role of GPER-1 in AMF mediated...

Acute rhinosinusitis among pediatric patients with allergic rhinitis: A nationwide, population-based cohort study

Research Institutes, Taiwan. Author Contributions Conceptualization: Shi-Wei Lin, Sheng-Kai Wang, Ming-Chi Lu, Chun-Lung Wang. Formal analysis: Malcolm Koo. Methodology: Malcolm Koo. Project ... administration: Ming-Chi Lu. Resources: Ming-Chi Lu. Supervision: Ming-Chi Lu, Chun-Lung Wang. Writing ? original draft: Shi-Wei Lin, Sheng-Kai Wang, Ming-Chi Lu, Chun-Lung Wang. Writing ? review & editing

Adherence to medical regimen after paediatric liver transplantation: a systematic review and meta-analysis

Adherence to medical regimen after paediatric liver transplantation: a systematic review and meta-analysis Xingchu Meng, Wei Gao, Kai Wang, Chao Han, Wei Zhang, Chao Sun Department of Organ

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

, ChinaJunhui Yu, Zilu Chen, Yunhua Wu, Jing Guo, Kai Wang, Xuejun Sun & Jianbao ZhengDepartment of Reproductive Medicine, First Affiliated Hospital of Xi’an Jiaotong University, 710061, Xi’an, Shaanxi, ChinaShan ... • Google Scholar Search for Yunhua Wu in:Nature Research journals • PubMed • Google Scholar Search for Jing Guo in:Nature Research journals • PubMed • Google Scholar Search for Kai Wang in:Nature Research