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127 papers found.
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Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders

from Teva, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg. Kaj Blennow has served as a consultant or at advisory

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments

Portelius, Kaj Blennow, Karen H. Ashe, Kathleen R. Zahs, Peng Liu. Formal analysis: Marianne K. O. Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H. Ashe ... , Kathleen R. Zahs, Peng Liu. Funding acquisition: Karen H. Ashe. Investigation: Marianne K. O. Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H. Ashe, Kathleen

Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery—a randomized trial

Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a systemic inflammatory response is considered a possible etiology. The effects of the glucocorticoid, methylprednisolone, on cerebrospinal fluid (CSF) markers of BBB function, neuroinflammation, and brain injury in patients...

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

PurposeStudies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181, P-tau181p) and mid-domain tau (i.e. total tau, T-tau). Moreover, these studies did not examine CSF tau levels in relation to cerebral glucose metabolism. We thus aimed to examine CSF tau measures, using both commercial and...

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease

BackgroundTo investigate how serum neurofilament light (NfL) concentration changes through the course of disease in familial Alzheimer’s disease (FAD) and to assess when NfL concentration first increases.MethodsNfL was measured using an ultrasensitive immunoassay in 117 serum samples from 61 individuals from families with PSEN1 or APP mutations in a longitudinal study (mean ± SD...

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

BackgroundThe Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for multicentre research studies and clinical trials. In this study, we aimed at deriving reference Centiloid thresholds that maximize the agreement against core...

The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain

Brain tumors are the most common form of solid tumors in children. Due to the increasing number of survivors, it is of importance to prevent long-term treatment-induced side effects. Montelukast, a leukotriene receptor antagonist, may have the desired neuroprotective properties. The aim of the study was to determine whether montelukast could reduce adverse effects of cranial...

A Review of Fluid Biomarkers for Alzheimer’s Disease: Moving from CSF to Blood

A set of core cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) includes total tau (T-tau), phosphorylated tau (P-tau) and β-amyloid 42 (Aβ42). These biomarkers reflect some of the key aspects of AD pathophysiology, including neuronal degeneration, tau phosphorylation with tangle formation, and Aβ aggregation with deposition of the peptide into plaques. The core...

Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia - A nested case control study

Conceptualization: Lina Bergman, Henrik Hagberg, Helena Åkerud. Data curation: Lina Bergman, Helena Åkerud. Formal analysis: Lina Bergman, Helena Åkerud. Funding acquisition: Kaj Blennow, Helena Åkerud ... . Investigation: Helena Åkerud. Methodology: Lina Bergman, Helena Åkerud. Project administration: Helena Kaihola, Helena Åkerud. Resources: Henrik Zetterberg, Kaj Blennow, Helena Åkerud. Supervision: Henrik

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides ending at amino acid (aa) 123 or 224 using high-resolution mass spectrometry. We...

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease

BackgroundA growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the screening of neurodegeneration in Alzheimer’s disease (AD).MethodsWith a single molecule array method (Simoa, Quanterix), plasma NfL concentrations were measured in 99 subjects with AD at the stage of mild cognitive...

Cerebrospinal fluid sCD27 levels indicate active T cell-mediated inflammation in premanifest Huntington's disease

clinical data collection. Author Contributions Conceptualization: Valter NiemelaÈ, Joachim Burman, Jimmy Sundblom. Data curation: Valter NiemelaÈ, Joachim Burman, Kaj Blennow, Henrik Zetterberg, Jimmy ... Sundblom. Formal analysis: Valter NiemelaÈ, Kaj Blennow, Henrik Zetterberg, Anders Larsson. Funding acquisition: Jimmy Sundblom. Investigation: Valter NiemelaÈ, Henrik Zetterberg, Anders Larsson, Jimmy

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Neurogranin (Ng) is a small 7.6 kDa postsynaptic protein that has been detected at elevated concentrations in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD), both as a full-length molecule and as fragments from its C-terminal half. Ng is involved in postsynaptic calcium (Ca) signal transduction and memory formation via binding to calmodulin in a Ca-dependent...

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

, Nae-Yuh Wang, Frederick E. Sieber. Formal analysis: Esther S. Oh, Nae-Yuh Wang. Funding acquisition: Esther S. Oh, Constantine G. Lyketsos. Methodology: Esther S. Oh, Kaj Blennow, Nae-Yuh Wang ... , Henrik Zetterberg, Constantine G. Lyketsos. Project administration: Esther S. Oh. Resources: Esther S. Oh, Kaj Blennow, Frederick E. Sieber, Constantine G. Lyketsos. Software: Esther S. Oh. Supervision

Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease

BackgroundIn this study, we tested to which extent possible between-center differences in standardized operating procedures (SOPs) for biobanking of cerebrospinal fluid (CSF) samples influence the homogeneity of the resulting aliquots and, consequently, the concentrations of the centrally analyzed selected Alzheimer’s disease biomarkers.MethodsProficiency processing samples (PPSs...

Correction to: A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

Following publication of the original article [1], the author reported errors in the formatting of the table. The details of the errors are as follows:

Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study

Surgery and anesthesia have been linked to postoperative cognitive disturbance and increased risk of Alzheimer’s disease. It is not clear by which mechanisms this increased risk for cognitive disease is mediated. Further, amyloid β production has been suggested to depend on the sleep-wake cycle and neuronal activity. The aim of the present study was to examine if cerebrospinal...

Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease

Biomarkers of Huntington’s disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein neurogranin and the microglial protein TREM2 are increased in...