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The change in lifestyle data during 9 years: the reliability and continuity of baseline health practices

ObjectivesTo reveal change patterns in self-reported lifestyle data for 9 years, and examine the characteristics of changes by type of lifestyle and ageing.MethodsThe authors used the lifestyle data of 7,080 male workers aged 20–59 who received checkups for 9 years. The proportions of change patterns during the 9 years were determined in seven health practices; smoking, eating...

Stress hormone levels in saliva after shogi competition are modified by stress coping strategies

ObjectiveUsing shogi, a representative table game popular in Japan, to model a stress situation, we investigated the modulatory effects of player characteristics on changes in the levels of cortisol and testosterone in the saliva of the players.MethodsSaliva samples were collected at the following time-points: (1) 30 min after awakening on the day of the shogi convention; (2...

Is habitual alcohol drinking associated with reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese?

Yuquan Lu 0 Kanehisa Morimoto 0 0 Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine , 2-2 Yamada-oka, Osaka 565-0871, Japan - Alcohol drinking-derived

Exposure level to cigarette tar or nicotine is associated with leukocyte DNA damage in male Japanese smokers

We investigated the number of cigarettes smoked daily, years of smoking, cigarette pack-years, levels of daily exposure to cigarette tar (LECT, mg/day) or nicotine (LECN, mg/day) in 53 male Japanese smokers using a questionnaire and measured each participant's baseline leukocyte DNA damage using the alkaline comet assay. The results showed that the baseline value of peripheral...

Long-term effects of lifestyle on multiple risk factors in male workers

Objectives To examine the long-term effects of lifestyle on the recovery from risk factors of cardiovascular disease and to discuss the difference in the effects of lifestyle modification in subjects with a single risk factor and those with multiple risk factors. Methods We used checkup data compiled for 6477 male workers, aged 20–59 years in 1995, with risk factors of...

Influence of personal patterns of behavior on the effects of Tai Chi: a pilot study

ObjectivesTo investigate the influence of individual patterns of personality and behavior on the change in mood status after a brief period of Tai Chi exercise.MethodsThe mood status in 22 healthy females was evaluated before and after a period of Tai Chi exercise using the Profile of Mood States (POMS) score. Patterns of personal behavior were also assessed by written...

Association between lifestyle factors and plasma adiponectin levels in Japanese men

Background Adiponectin is an adipocyte-specific protein that plays a role in obesity, insulin resistant, lipid metabolism, and anti-inflammation. Hypoadiponectinemia may be associated with a higher risk for type 2 diabetes and cardiovascular disease. Some studies suggest that adiponectin levels are modulated by lifestyle factors, but little is known about the associations between...

4-Nitroquinoline 1-Oxide Forms 8-Hydroxydeoxyguanosine in Human Fibroblasts through Reactive Oxygen Species

4-Nitroquinoline 1-oxide (4NQO) is thought to elicit its carcinogenicity by producing DNA adducts after being metabolized to 4-hydroxyaminoquinoline 1-oxide, which forms 8-hydroxydeoxyguanosine (8OHdG), oxidative damage. To determine whether reactive oxygen species (ROS) are involved in the generation of 8OHdG by 4NQO, we used high-performance liquid chromatography and...

ACCELERATED PAPER: Relationship between the intracellular reactive oxygen species and the induction of oxidative DNA damage in human neutrophil-like cells

Tom Takeuchi 0 Madoka Nakajima 0 Kanehisa Morimoto 0 0 Department of Hygiene and Preventive Medicine, Osaka University School of Medicine , 2-2 Yamada-oka, Suita, 565 Japan 'To whom correspondence

Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions

Madoka Nakajima 0 Torn Takeuchi 0 Kanehisa Morimoto 0 0 Department of Hygiene and Preventive Medicine, Osaka University School of Medicine , 2-2 Yamadaoka Suita, Osaka 565, Japan 'To whom

Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU)

We conducted a collaborative validation study, under the auspices of the Japanese Ministry of Labour, on the in vitro micronucleus test to see if it could be used as an alternative to the in vitro chromosome aberration test for evaluation of chemical safety. We used the Chinese hamster lung cell line (CHL/IU), which is the most widely used system for the latter test in Japan, and...


Sugimoto 1 Kanehisa Morimoto. 1 0 Department of Occupational Health, Osaka Prefectural Institute of Public Health , Osaka 520 , Japan 1 'Department of Hygiene and Preventive Medicine, Osaka University