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Developing and validating risk prediction models in an individual participant data meta-analysis

Background Risk prediction models estimate the risk of developing future outcomes for individuals based on one or more underlying characteristics (predictors). We review how researchers develop and validate risk prediction models within an individual participant data (IPD) meta-analysis, in order to assess the feasibility and conduct of the approach. Methods A qualitative review...

Developing and validating risk prediction models in an individual participant data meta-analysis

Risk prediction models estimate the risk of developing future outcomes for individuals based on one or more underlying characteristics (predictors). We review how researchers develop and validate risk prediction models within an individual participant data (IPD) meta-analysis, in order to assess the feasibility and conduct of the approach. A qualitative review of the aims...

Comparison of approaches to estimate confidence intervals of post-test probabilities of diagnostic test results in a nested case-control study

Yvonne Vergouwe 2 A Rogier T Donders 1 Karel GM Moons 0 0 Julius Center for Health Sciences and Primary Care And Division of Anesthesiology, Intensive Care Care and Emergency Medicine, University Medical

Prediction models for clustered data: comparison of a random intercept and standard regression model

Background When study data are clustered, standard regression analysis is considered inappropriate and analytical techniques for clustered data need to be used. For prediction research in which the interest of predictor effects is on the patient level, random effect regression models are probably preferred over standard regression analysis. It is well known that the random effect...

Incorporating quality assessments of primary studies in the conclusions of diagnostic accuracy reviews: a cross-sectional study

Background Drawing conclusions from systematic reviews of test accuracy studies without considering the methodological quality (risk of bias) of included studies may lead to unwarranted optimism about the value of the test(s) under study. We sought to identify to what extent the results of quality assessment of included studies are incorporated in the conclusions of diagnostic...

Triage of frail elderly with reduced exercise tolerance in primary care (TREE). a clustered randomized diagnostic study

BackgroundExercise reduced tolerance and breathlessness are common in the elderly and can result in substantial loss in functionality and health related quality of life. Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are common underlying causes, but can be difficult to disentangle due to overlap in symptomatology. In addition, other potential causes such as...

The influence of medical testing on patients’ health: an overview from the gynecologists’ perspective

Bossuyt 0 Karel GM Moons Marcel GW Dijkgraaf Kirsten J McCaffery Ben Willem J Mol 1 Brent C Opmeer 0 Department of Clinical Epidemiology , Biostatistics and Bioinformatics , Academic Medical Center

The influence of medical testing on patients’ health: an overview from the gynecologists’ perspective

A medical tests may influence the health of patients by guiding clinical decisions, such as treatment in case of a positive test result. However, a medical test can influence the health of patients through other mechanisms as well, like giving reassurance. To make a clinical recommendation about a medical test, we should be aware of the full range of effects of that test on...

Child abuse inventory at emergency rooms: CHAIN-ER rationale and design

Background Child abuse and neglect is an important international health problem with unacceptable levels of morbidity and mortality. Although maltreatment as a cause of injury is estimated to be only 1% or less of the injured children attending the emergency room, the consequences of both missed child abuse cases and wrong suspicions are substantial. Therefore, the accuracy of...

The Patient Health Questionnaire-9 for detection of major depressive disorder in primary care: consequences of current thresholds in a crosssectional study

Background There is a need for brief instruments to ascertain the diagnosis of major depressive disorder. In this study, we present the reliability, construct validity and accuracy of the PHQ-9 and PHQ-2 to detect major depressive disorder in primary care. Methods Cross-sectional analyses within a large prospective cohort study (PREDICT-NL). Data was collected in seven large...

A systematic comparison of software dedicated to meta-analysis of causal studies

Background Our objective was to systematically assess the differences in features, results, and usability of currently available meta-analysis programs. Methods Systematic review of software. We did an extensive search on the internet (Google, Yahoo, Altavista, and MSN) for specialized meta-analysis software. We included six programs in our review: Comprehensive Meta-analysis...

Advantages of the nested case-control design in diagnostic research

Karel GM Moons 1 0 The Children's Hospital at Westmead , Sydney , Australia 1 Julius Center for Health Sciences and Primary Care, University Medical Center , Utrecht , The Netherlands Background

Development and validation of MIX: comprehensive free software for meta-analysis of causal research data

Background Meta-analysis has become a well-known method for synthesis of quantitative data from previously conducted research in applied health sciences. So far, meta-analysis has been particularly useful in evaluating and comparing therapies and in assessing causes of disease. Consequently, the number of software packages that can perform meta-analysis has increased over the...

Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials

Line Rode Katharina Klein Ann Tabor Elin etingz John C Morrison Everett F Magann Christian M Briery Vicente Serra Alfredo Perales Juan Meseguer Anwar H Nassar Arianne C Lim Karel GM Moons 0 Anneke Kwee

A randomised clinical trial on cardiotocography plus fetal blood sampling versus cardiotocography plus ST-analysis of the fetal electrocardiogram (STAN®) for intrapartum monitoring

monitoring Westerhuis 3 Karel GM Moons 1 Erik van Beek 0 Saskia M Bijvoet 7 Addy P Drogtrop 6 Herman P van Geijn 7 Jan MM van Lith 5 Ben WJ Mol 4 9 Jan G Nijhuis 8 S Guid Oei 9 Martina M Porath 9