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„Diabesity“ – Adipositas und Typ-2-Diabetes (Update 2019)

ZusammenfassungAdipositas und Typ-2-Diabetes werden seit einigen Jahren vermehrt unter dem Namen „Diabesity“ zusammengefasst. Das trägt dem Umstand Rechnung, dass die Adipositas dem Diabetes in den meisten Fällen häufig vorangeht und wohl der wichtigste Faktor in der weltweiten Zunahme des Typ-2-Diabetes ist. Der Body-Mass-Index (BMI) ist individuell betrachtet ein sehr grobes Ma...

Ernährungsempfehlungen bei Diabetes mellitus (Update 2019)

ZusammenfassungEs besteht breiter Konsens, dass eine effiziente Diabetes-Therapie in den meisten Fällen auch von einer Modifikation des Lebensstils begleitet sein muss. Das bedeutet für die Patienten in der Regel eine Normalisierung des Körpergewichts (Gewichtsreduktion und/oder Halten des Gewichts) in Kombination mit einer Veränderung des Bewegungs- und Ernährungsverhaltens.Die...

Changes in Bone Mineral Density Following Weight Loss Induced by One-Anastomosis Gastric Bypass in Patients with Vitamin D Supplementation

& Eva Winzer 2,3 & Karin Schindler 1 & Igor Grabovac 3 & Franz Kainberger 5 & Michael Krebs 1 & Friedrich Hoppichler 2,6 & Felix Langer 7 & Gerhard Prager 7 & Rodrig Marculescu 8 & Bernhard Ludvik 1,9

Management of Pregnant Women after Bariatric Surgery

The prevalence of obesity is growing worldwide, and strategies to overcome this epidemic need to be developed urgently. Bariatric surgery is a very effective treatment option to reduce excess weight and often performed in women of reproductive age. Weight loss influences fertility positively and can resolve hormonal imbalance. So far, guidelines suggest conceiving after losing...

Adipositas und Typ 2 Diabetes

Adipositas und Typ 2 Diabetes werden heute gerne unter dem Namen „Diabesity“ zusammengefasst. Das trägt dem Umstand Rechnung, dass die Adipositas dem Diabetes häufig vorangeht und wohl der wichtigste Faktor in der Zunahme des Typ 2 Diabetes mellitus ist. Der Body-Mass-Index (BMI) ist nur ein sehr grobes Maß der Körperverfettung. Sogar Normalgewichtige können bei Muskelmangel zu...

Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial

Background Bariatric patients often suffer from vitamin D deficiency (VDD), and both, morbid obesity and VDD, are related to non-alcoholic fatty liver disease. However, limited data are available regarding best strategies for treating VDD, particularly, in bariatric patients undergoing omega-loop gastric bypass (OLGB). Therefore, we examined the efficacy and safety of a forced...

The Effect of Roux-en-Y vs. Omega-Loop Gastric Bypass on Liver, Metabolic Parameters, and Weight Loss

Background Omega-loop gastric bypass (OLGB) results in weight loss (WL) but data on its impact on liver and glucose metabolism compared to Roux-en-Y gastric bypass (RYGB) is lacking. Therefore, the aim of this study was to compare the development of hepatic and metabolic markers as well as WL between the above-mentioned surgical groups during the first postoperative year. Methods...

Prevalence of Liver Fibrosis and its Association with Non-invasive Fibrosis and Metabolic Markers in Morbidly Obese Patients with Vitamin D Deficiency

Background Morbidly obese patients are at risk for non-alcoholic fatty liver disease (NAFLD) and vitamin D deficiency (VDD). Non-alcoholic steatohepatitis (NASH) is the progressive variant of NAFLD and can advance to fibrosis, cirrhosis, and liver cancer. We aimed to examine prevalence of liver fibrosis and its non-invasive predictors in bariatric patients with VDD (<75 nmol/l...

The Patient- And Nutrition-Derived Outcome Risk Assessment Score (PANDORA): Development of a Simple Predictive Risk Score for 30-Day In-Hospital Mortality Based on Demographics, Clinical Observation, and Nutrition

Objective To develop a simple scoring system to predict 30 day in-hospital mortality of in-patients excluding those from intensive care units based on easily obtainable demographic, disease and nutrition related patient data. Methods Score development with general estimation equation methodology and model selection by P-value thresholding based on a cross-sectional sample of 52...

The link between obesity and vitamin D in bariatric patients with omega-loop gastric bypass surgery - a vitamin D supplementation trial to compare the efficacy of postoperative cholecalciferol loading (LOAD): study protocol for a randomized controlled trial

Background Beyond its classical role in calcium homoeostasis and bone metabolism, vitamin D deficiency has been found to be associated with several diseases, including diabetes, non-alcoholic fatty liver disease, and even obesity itself. Importantly, there are limited data on therapeutic strategies for vitamin D deficiency in bariatric patients, and the procedure-specific...