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Immortalization of common marmoset monkey fibroblasts by piggyBac transposition of hTERT

Contributions Conceptualization: Katharina Debowski, Ru?diger Behr. Data curation: Stoyan Petkov, Tobias Kahland, Orr Shomroni, Thomas Lingner, Gabriela Formal analysis: Stoyan Petkov, Tobias Kahland, Orr ... Shomroni, Thomas Lingner, Gabriela Salinas, Sigrid Fuchs, Katharina Debowski, Ru?diger Behr. Investigation: Stoyan Petkov, Katharina Debowski. Methodology: Tobias Kahland, Orr Shomroni, Thomas Lingner

Differentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent Reporter

Curative approaches for eye cataracts and other eye abnormalities, such as myopia and hyperopia currently suffer from a lack of appropriate models. Here, we present a new approach for in vitro growth of lentoid bodies from induced pluripotent stem (iPS) cells as a tool for ophthalmological research. We generated a transgenic mouse line with lens-specific expression of a...

The transcriptomes of novel marmoset monkey embryonic stem cell lines reflect distinct genomic features

information accompanies this paper at http://www.nature.com/srep Competing financial interests: Katharina Debowski is employed by STEMCELL Technologies SARL from March 1st 2016 on. All other authors declare

Non-Viral Generation of Marmoset Monkey iPS Cells by a Six-Factor-in-One-Vector Approach

Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived...

CRIS—A Novel cAMP-Binding Protein Controlling Spermiogenesis and the Development of Flagellar Bending

The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor involved in sperm function) that is unrelated to any of the other members of this protein family. CRIS is exclusively expressed in...