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Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele

Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele Kumi Sakurada,1,* Takeshi Kozaru,2,* Kazuo Yamada,1 Masashi Nibuya,1

Differential requirements of hippocampal de novo protein and mRNA synthesis in two long-term spatial memory tests: Spontaneous place recognition and delay-interposed radial maze performance in rats

Hippocampal de novo mRNA and protein synthesis has been suggested to be critical for long-term spatial memory. However, its requirement in each memory process (i.e. encoding, consolidation and retrieval) and the differences in the roles of de novo mRNA and protein synthesis in different situations where spatial memory is tested have not been thoroughly investigated. To address...

Monitoring of Serial Presurgical and Postsurgical Changes in the Serum Proteome in a Series of Patients with Calcific Aortic Stenosis

therapeutic strategies for CAS. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. Authors’ Contribution Kazumi Satoh and Kazuo Yamada

A prospective naturalistic study of antidepressant-induced jitteriness/anxiety syndrome

A prospective naturalistic study of antidepressant-induced jitteriness/anxiety syndrome Tsuyoto Harada, Ken Inada, Kazuo Yamada, Kaoru Sakamoto, Jun Ishigooka Department of Psychiatry, Tokyo Women’s ... e a r c h; Tsuyoto harada; Ken inada; Kazuo Yamada; Kaoru sakamoto; Jun ishigooka - Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract wil

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma

Nicotinamide (Nam) phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in mammalian NAD synthesis, catalyzing nicotinamide mononucleotide (NMN) formation from Nam and 5-phosphoribosyl 1-pyrophosphate (PRPP). NAMPT has also been described as an adipocytokine visfatin with a variety of actions, although physiological significance of this protein remains unclear. It has...

Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population

We recently reported the results of a genome-wide association study (GWAS) of schizophrenia in the Japanese population. In that study, a single nucleotide polymorphism (SNP) (rs3106653) in the KCNJ3 (potassium inwardly rectifying channel, subfamily J, member 3) gene located at 2q24.1 showed association with schizophrenia in two independent sample sets. KCNJ3, also termed GIRK1 or...

Population-Specific Haplotype Association of the Postsynaptic Density Gene DLG4 with Schizophrenia, in Family-Based Association Studies

The post-synaptic density (PSD) of glutamatergic synapses harbors a multitude of proteins critical for maintaining synaptic dynamics. Alteration of protein expression levels in this matrix is a marked phenomenon of neuropsychiatric disorders including schizophrenia, where cognitive functions are impaired. To investigate the genetic relationship of genes expressed in the PSD with...

Genetic Variants on 3q21 and in the Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: A Genetic Association Study

Background Recent genome-wide association studies (GWASs) investigating bipolar disorder (BD) have detected a number of susceptibility genes. These studies have also provided novel insight into shared genetic components between BD and schizophrenia (SCZ), two major psychotic disorders. To examine the replication of the risk variants for BD and the pleiotropic effect of the...

Genome-Wide Association Study of Schizophrenia in Japanese Population

Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits. Genetic variants should explain a considerable portion of the risk for schizophrenia, and genome-wide association study (GWAS) is a potentially powerful tool for identifying the risk variants that underlie the disease. Here, we report the results of a three-stage analysis of three...

Ablation of Mrds1/Ofcc1 Induces Hyper-γ-Glutamyl Transpeptidasemia without Abnormal Head Development and Schizophrenia-Relevant Behaviors in Mice

Mutations in the Opo gene result in eye malformation in medaka fish. The human ortholog of this gene, MRDS1/OFCC1, is a potentially causal gene for orofacial cleft, as well as a susceptibility gene for schizophrenia, a devastating mental illness. Based on this evidence, we hypothesized that this gene could perform crucial functions in the development of head and brain structures...

A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population

Background Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research We examined the...

Association of Transcription Factor Gene LMX1B with Autism

Yamada Yoshimi Iwayama Tomoko Toyota Masatsugu Tsujii Yasuhide Iwata Katsuaki Suzuki Hideo Matsuzaki Keiko Iwata Toshiro Sugiyama Takeo Yoshikawa Norio Mori Kenji Hashimoto, Chiba University Center for

Increased Stathmin1 Expression in the Dentate Gyrus of Mice Causes Abnormal Axonal Arborizations

Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in multiple brain functions. To clarify the cause of abnormal behavior in PACAP deficient-mice, we attempted the identification of genes whose expression was altered in the dentate gyrus of PACAP-deficient mice using the differential display method. Expression of stathmin1 was up-regulated in the dentate gyrus...

Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics

Molecular Psychiatry, RIKEN Brain Science Institute , 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan 2 Mizuho Nakajima Eiji Hattori Kazuo Yamada Yoshimi Iwayama Tomoko Toyota Yasuhide Iwata Kenji J

Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype

Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI with C3H/He (C3) animals that show low PPI. We detected six major loci for PPI, six for the acoustic startle response, and four...

Two Component Character of S(k,ω) in Superfluid 4He

Two Component Character of S (k 0 ro) in Superfluid 'He 0 0 Kazuo YAMADA Department of Physics, Nagoya University , Nagoya 464 (Received November 19, 1979) The response functions in superfluid 'He

Quantum Hydrodynamics and Two-Fluid Dynamics

Kazumasa MIYAKE 0 Kazuo YAMADA 0 0 Department of Physics, iVagoya University , Nagoya 464 lt is shown how two fluid dynamical equations for superfluid He' are derived from quantum hydrodynamical

Dynamics of Bose-Einstein Condensate and Two-Fluid Hydrodynamics

Kazumasa MIYAKE 0 Kazuo YAMADA 0 0 Department of Physics, Nagoya University , Nagoya 464 1 q , j;q, J!. ;q), the linearized forms of which are written as follows: Dynamics of BoseEinstein Condensate

Dynamics of Longitudinal Component in Ordered Spin Systems

Dynamical behaviors of longitudinal component in the ordered planar and isotropic Heisenberg systems are examined in the hydrodynamical spin wave approximation. It is found that the long time behaviors are not subject to an exponential decay law in time which leads to a diffusive motion, but is represented by the inverse power law in time associated with the oscillation of spin...