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SO2-Induced Neurotoxicity Is Mediated by Cyclooxygenases-2-Derived Prostaglandin E2 and its Downstream Signaling Pathway in Rat Hippocampal Neurons

Sulfur dioxide (SO2) pollution in atmospheric environment is involved in neurotoxicity and increased risk for hospitalization and mortality of many brain disorders; however, our understanding of the mechanisms by which SO2 caused harmful insults on neurons remains elusive. Here, we show that SO2 exposure produced a neuronal insult, and the neurotoxic effect was likely via...

Oesophageal cancer and occupational exposure to rubber: A nested case-control study

KE LI$ 0 SHUNZHANG YU% 0 0 $Preventive Branch, Shantou University Medical College , Shantou 515031 , People's Republic of China; %Department of Epidemiology, Shanghai Medical University , Shanghai

A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Olopatadine Concentration in Human Plasma

A sensitive and rapid method based on liquid chromatography-tandem mass spectrometry (MS-MS) was developed for the determination of olopatadine in human plasma. Sample preparations were carried out by protein precipitation with the addition of acetonitrile followed by liquid-liquid extraction with ethyl acetate/dichloromethane after internal standard (IS, amitriptyline) spiked...