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An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

BackgroundCardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cytisine, and sophocarpine being the primary toxic components.MethodsIn this study...

Lipocalin 2: a potential therapeutic target for breast cancer metastasis

Lipocalin 2: a potential therapeutic target for breast cancer metastasis Chenxia Hu,1 Ke Yang,1 Mengjie Li,1 Weiping Huang,2 Fengxue Zhang,2 Hongqi Wang2 1School of Pharmaceutical Science, Guangzhou

Vertical stratification of bacteria and the chemical compounds in crude oil-contaminated soil layers of the semi-deserted Dzungharian Basin

Contributions Conceptualization: Jiang-Ke Yang. Data curation: Jiang-Ke Yang. Formal analysis: Jiang-Ke Yang. Funding acquisition: Jiang-Ke Yang, Qun-Fang Chao. Investigation: Jian-Fang Liang, Lu-Mei Xiao ... , Yang Yang. 18 / 20 Methodology: Jiang-Ke Yang. Project administration: Jiang-Ke Yang, Qun-Fang Chao. Supervision: Jiang-Ke Yang, Qun-Fang Chao. Writing ? original draft: Jiang-Ke Yang. Writing

Assessment of health professional education across five Asian countries—a protocol

There is an increasing consensus globally that the education of health professionals is failing to keep pace with scientific, social, and economic changes transforming the healthcare environment. This catalyzed a movement in reforming education of health professionals across Bangladesh, China, India, Thailand, and Vietnam who jointly volunteered to implement and conduct...

Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process

Jiang,3 Kerong Dai,1 Ke Yang,2 Yongqiang Hao1 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of

Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme

The cellulose binding domain (CBD) of cellulase binding to cellulosic materials is the initiation of a synergistic action on the enzymatic hydrolysis of the most abundant renewable biomass resources in nature. The binding of the CBD domain to cellulosic substrates generally relies on the interaction between the aromatic amino acids structurally located on the flat face of the CBD...

Reaction and Characterization of Low-Temperature Effect of Transition Nanostructure Metal Codoped SCR Catalyst

; rf.liamtoh@gnepup, and Lulu Cai; moc.621@ululxzl Received 24 January 2017; Accepted 28 February 2017; Published 20 September 2017 Academic Editor: Jinwei Gao Copyright © 2017 Ke Yang et al. This is an open ... that they have no conflicts of interest. Authors’ Contributions Quan Xu, Peng Pu, and Li Cao conceived and designed the experiments; Ke Yang and Weiwei Xiao performed the experiments; Jiaojiao Bai, Li

Prognostic value of plasma EGFR ctDNA in NSCLC patients treated with EGFR-TKIs

Objective Epidermal growth factor receptor (EGFR) specific mutations have been known to improve survival of patients with non-small-cell lung carcinoma (NSCLC). However, whether there are any changes of EGFR mutations after targeted therapy and its clinical significance is unclear. This study was to identify the status of EGFR mutations after targeted therapy and predict the...

DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages

Author notes Ke Yang, Xinhe Liu and Yan Liu contributed equally to this work. AffiliationsDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 ... Zhang & Weifeng ShenDepartment of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, ChinaYan Liu AuthorsSearch for Ke Yang in:Nature Research

Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle

Chongqing Medical University, Chongqing 400014, China Correspondence should be addressed to Ke Yang; moc.361@41101287 Received 5 July 2016; Revised 4 January 2017; Accepted 24 January 2017; Published 27 ... Foundation of China (no. 81301350) and Basic and Advanced Research Projects in Chongqing (no. cstc2013jcyjA10021). Ke Yang was supported by the National Natural Science Foundation of China (no. 81371718

Association of long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus

, Anhui Medical University, Anhui, P. R. ChinaJun Li, Guo-Cui Wu, Tian-Ping Zhang, Xiao-Ke Yang, Shuang-Shuang Chen, Lian-Ju Li, Shu-Zhen Xu, Tian-Tian Lv, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing YeAnhui ... Province Key Laboratory of Major Autoimmune Diseases, Anhui, P. R. ChinaJun Li, Guo-Cui Wu, Tian-Ping Zhang, Xiao-Ke Yang, Shuang-Shuang Chen, Lian-Ju Li, Shu-Zhen Xu, Tian-Tian Lv, Rui-Xue Leng, Hai-Feng

Backbone cup – a structure design competition based on topology optimization and 3D printing

This paper addresses a structure design competition based on topology optimization and 3D Printing, and proposes an experimental approach to efficiently and quickly measure the mechanical performance of the structures designed using topology optimization. Since the topology optimized structure designs are prone to be geometrically complex, it is extremely inconvenient to...

Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway

Background Wogonin is an encouraging choice for clinical use owing to its potent anti-tumor and anti-inflammatory effects with the high safety profile. However, wogonin for targeted therapy of lymphoma was not well addressed. In this study, we focused on its anticancer effect alongside with the underlying mechanisms for targeted therapy in EBV-positive lymphoma. This will...

Backbone cup – a structure design competition based on topology optimization and 3D printing

This paper addresses a structure design competition based on topology optimization and 3D Printing, and proposes an experimental approach to efficiently and quickly measure the mechanical performance of the structures designed using topology optimization. Since the topology optimized structure designs are prone to be geometrically complex, it is extremely inconvenient to...

Dramatically Enhanced Visible Light Response of Monolayer ZrS2 via Non-covalent Modification by Double-Ring Tubular B20 Cluster

The ability to strongly absorb light is central to solar energy conversion. We demonstrate here that the hybrid of monolayer ZrS2 and double-ring tubular B20 cluster exhibits dramatically enhanced light absorption in the entire visible spectrum. The unique near-gap electronic structure and large built-in potential at the interface will lead to the robust separation of...

Flexoelectric effect in an in-plane switching (IPS) liquid crystal cell for low-power consumption display devices

ScholarSearch for Dong-Woo Kim in:Nature Research journals • PubMed • Google ScholarSearch for Deng-Ke Yang in:Nature Research journals • PubMed • Google ScholarSearch for Joong Hee Lee in:Nature Research

Structural Phase Transition of ThC Under High Pressure

Thorium monocarbide (ThC) as a potential fuel for next generation nuclear reactor has been subjected to its structural stability investigation under high pressure, and so far no one reported the observation of structure phase transition induced by pressure. Here, utilizing the synchrotron X-ray diffraction technique, we for the first time, experimentally revealed the phase...

Black hole solution and strong gravitational lensing in Eddington-inspired Born–Infeld gravity

A new theory of gravity called Eddington-inspired Born–Infeld (EiBI) gravity was recently proposed by Bañados and Ferreira. This theory leads to some exciting new features, such as free of cosmological singularities. In this paper, we first obtain a charged EiBI black hole solution with a nonvanishing cosmological constant when the electromagnetic field is included in. Then based...