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Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Background Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are...

Low serum eicosapentaenoic acid / arachidonic acid ratio in male subjects with visceral obesity

Background Visceral fat accumulation is caused by over-nutrition and physical inactivity. Excess accumulation of visceral fat associates with atherosclerosis. Polyunsaturated fatty acids have an important role in human nutrition, but imbalance of dietary long-chain polyunsaturated fatty acids, especially low eicosapentaenoic acid (EPA) / arachidonic acid (AA) ratio, is associated...

Clinical significance of visceral fat reduction through health education in preventing atherosclerotic cardiovascular disease - Lesson from the Amagasaki Visceral Fat Study: A Japanese perspective

reviewed/edited manuscript. All authors read and approved the final version of the manuscript. Authors information Ken Kishida, MD, PhD, is an assistance professor at the Department of Metabolism and

Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report

Background Atherosclerosis is an age-related disease. Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated circulating C1q and C1q-APN levels in Japanese men including elderly men. Findings The study subjects were 509 Japanese men including elderly men. Serum levels of...

Sleep-wake cycle irregularities in type 2 diabetics

-cholesterol; T2DM: type 2 diabetes mellitus. Competing interests Ken Kishida and Tohru Funahashi are members of the Department of Metabolism and Atherosclerosis, a sponsored course endowed by Kowa Co. Ltd

High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Background The complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and serum C1q binding adiponectin (C1q-APN) can be measured. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina...

Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a CAG repeat in the androgen receptor (AR) gene. Mutant AR has been postulated to alter the expression of genes important for mitochondrial function and induce mitochondrial dysfunction. Here, we show that the expression levels of peroxisome proliferator-activated receptor-γ (PPARγ), a...

Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution

Background B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities. Intraabdominal fat accumulation is associated with atherosclerotic cardiovascular diseases and cardiac dysfunction. Circulating BNP levels are relatively low (within the normal limits) in obesity...

Serum C1q- binding adiponectin in maintenance hemodialysis patients

Background Patients on maintenance hemodialysis (HD) have much higher levels of adiponectin (Total-APN). Adiponectin and C1q form a protein complex in human blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We recently reported that C1q-APN/Total-APN ratio rather than Total-APN correlated with atherosclerosis in diabetics. However, the characteristics of C1q-APN...

Serum C1q- binding adiponectin in maintenance hemodialysis patients

Patients on maintenance hemodialysis (HD) have much higher levels of adiponectin (Total-APN). Adiponectin and C1q form a protein complex in human blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We recently reported that C1q-APN/Total-APN ratio rather than Total-APN correlated with atherosclerosis in diabetics. However, the characteristics of C1q-APN in HD...

High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome

Background The prevalence of gastroesophageal reflux disease (GERD) has been increasing worldwide. Abdominal obesity or visceral fat accumulation rather than simple obesity is associated with GERD. Previous reports demonstrated the association between GERD and type 2 diabetes mellitus (T2DM). Signification of visceral fat accumulation and adiponectin in T2DM patients with GERD...

A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus- a randomized controlled trial START-J study

“Department of Metabolism and Atherosclerosis”, a sponsored course endowed by Kowa Co. Ltd. Toshiyuki Hibuse, Ken Kishida, Norikazu Maeda, and Hitoshi Nishizawa are consultants and promotional speakers for ONO

Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing

approved the final version of the manuscript. Competing interests Ken Kishida and Tohru Funahashi are members of the “Department of Metabolism and Atherosclerosis”, a sponsored course endowed by Kowa Co. Ltd

Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study

Background Circulating thiobarbituric acid-reacting substance (TBARS) levels, a marker of systemic oxidative stress, are predictive of cardiovascular events. However, they has not been evaluated in Japanese, especially with regard to the factors that contribute to the changes in circulating TBARS levels. We investigated the cross-sectional and longitudinal relationships between...

One-Year Reductions in Body Weight and Blood Pressure, but Not in Visceral Fat Accumulation and Adiponectin, Improve Urinary Albumin-to-Creatinine Ratio in Middle-Aged Japanese Men

accumulation and adiponectin. HIDEAKI NAKATSUJI, MD1 KEN KISHIDA, MD, PHD1 TOHRU FUNAHASHI, MD, PHD1 MIDORI NOGUCHI, RN2 TOMOKO OGAWA, RN2 YUKIYOSHI OKAUCHI, MD, PHD1 HITOSHI NISHIZAWA, MD, PHD3 TADASHI ... 5Sumitomo Hospital, Osaka, Japan. Corresponding author: Ken Kishida, kkishida@ imed2.med.osaka-u.ac.jp. DOI: 10.2337/dc10-0739 © 2010 by the American Diabetes Association. Readers may use this article as

Changes in Serum Adiponectin Concentrations Correlate With Changes in BMI, Waist Circumference, and Estimated Visceral Fat Area in Middle-Aged General Population

APN. YUKIYOSHI OKAUCHI, MD1 KEN KISHIDA, MD1 TOHRU FUNAHASHI, MD1 MIDORI NOGUCHI, RN2 TOMOKO OGAWA, RN2 MIWA RYO, MD1 KOHEI OKITA, MD1 HIROMI IWAHASHI, MD1 AKIHISA IMAGAWA, MD1 TADASHI NAKAMURA

Visceral Fat Is a Major Contributor for Multiple Risk Factor Clustering in Japanese Men With Impaired Glucose Tolerance

OBJECTIVE—The significance of abdominal visceral fat accumulation was evaluated in Japanese men with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS—The IGT subjects (n = 123) were aged 55 ± 9 years with a BMI of 24 ± 3 kg/m2. The 148 control subjects with normal glucose tolerance (NGT) were matched for age and BMI. IGT and NGT were classified according to the 1985...

Coordinated Regulation of Fat-Specific and Liver-Specific Glycerol Channels, Aquaporin Adipose and Aquaporin 9

Hiroshi Kuriyama Iichiro Shimomura Ken Kishida Hidehiko Kondo Naoki Furuyama Hitoshi Nishizawa Norikazu Maeda Morihiro Matsuda Hiroyuki Nagaretani Shinji Kihara Tadashi Nakamura Yoshihiro Tochino

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Hitoshi Nishizawa Iichiro Shimomura Ken Kishida Norikazu Maeda Hiroshi Kuriyama Hiroyuki Nagaretani Morihiro Matsuda Hidehiko Kondo Naoki Furuyama Shinji Kihara Tadashi Nakamura Yoshihiro Tochino

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

Norikazu Maeda Masahiko Takahashi Tohru Funahashi Shinji Kihara Hitoshi Nishizawa Ken Kishida Hiroyuki Nagaretani Morihiro Matsuda Ryutaro Komuro Noriyuki Ouchi Hiroshi Kuriyama Kikuko Hotta Tadashi