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7 papers found.
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Mouse model of ocular hypertension with retinal ganglion cell degeneration

Clint L. Makino for providing equipment. Author Contributions Conceptualization: Ryo Mukai, Kip M. Connor. Data curation: Ryo Mukai, Dong Ho Park. Formal analysis: Ryo Mukai, Dong Ho Park. Funding ... acquisition: Dong Ho Park, Clifford B. Kim, Joan W. Miller, Kip M. Connor. Investigation: Ryo Mukai, Dong Ho Park, Yoko Okunuki, Eiichi Hasegawa, Garrett Klokman, Clifford B. Kim, Anitha Krishnan, Meredith

Attenuation of choroidal neovascularization by dietary intake of ω-3 long-chain polyunsaturated fatty acids and lutein in mice

. Supervision: Kip M. Connor, Kazuhiro Kimura. Writing ± original draft: Ryoji Yanai. Writing ± review & editing: Kip M. Connor, Kazuhiro Kimura. 11 / 13 12 / 13 26. 1. Lim LS , Mitchell P , Seddon JM , Holz

Revisiting the mouse model of oxygen-induced retinopathy

Revisiting the mouse model of oxygen-induced retinopathy Clifford B Kim,1,2 Patricia A D’Amore,2–4 Kip M Connor1,2 1Angiogenesis Laboratory, Massachusetts Eye and Ear, 2Department of Ophthalmology, Harvard Medical School, 3Schepens Eye Research Institute, Massachusetts Eye and Ear, 4Department of Pathology, Harvard Medical School, Boston, MA, USA Abstract: Abnormal blood vessel...

Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function

Omega (ω)–3 long-chain polyunsaturated fatty acids (LCPUFAs) inhibit the production of inflammatory mediators and thereby contribute to the regulation of inflammation. Experimental autoimmune uveitis (EAU) is a well-established animal model of autoimmune retinal inflammation. To investigate the potential effects of dietary intake of ω-3 LCPUFAs on uveitis, we examined the anti...

Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of...

EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay

EGFL7 is a secreted angiogenic factor, which in contrast to the well-known secreted angiogenic molecules VEGF and FGF-2, is almost exclusively expressed by endothelial cells and may act in an autocrine fashion. Prior studies have shown EGFL7 to mediate its angiogenic effects by interfering with the Notch pathway and/or via the intronic miR126. Less is known about its effects on...

Characterization of a Spontaneous Retinal Neovascular Mouse Model

Background Vision loss due to vascular disease of the retina is a leading cause of blindness in the world. Retinal angiomatous proliferation (RAP) is a subgroup of neovascular age-related macular degeneration (AMD), whereby abnormal blood vessels develop in the retina leading to debilitating vision loss and eventual blindness. The novel mouse strain, neoretinal vascularization 2...