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Characterization of circulating DNA in plasma of patients after allogeneic bone grafting

release DNA into the blood since we did not measure Y-DNA with our technique. KeywordsBone allograft Guided bone regeneration Circulating DNA Patient safety  Klaus Pantel and Heidi Schwarzenbach should

Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients

Volkmar Müller in:Nature Research journals • PubMed • Google Scholar Search for Leticia Oliviera-Ferrer in:Nature Research journals • PubMed • Google Scholar Search for Klaus Pantel in:Nature Research ... Framework Programme (FP7/2007-2013). Author information AffiliationsDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, GermanyQingtao Ni, Ines Stevic, Chi Pan, Klaus

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases

The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung...

Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer

Here we describe the establishment and characterization of an AR+, PSMA+, ERG+, PTEN−/−, CHD1+/− patient-derived xenograft (PDX) model termed ‘C5’, which has been developed from a 60 years old patient suffering from castration-resistant prostate cancer (CRPC). The patient underwent radical prostatectomy, showed early tumor marker PSA recurrence and, one year after surgery...

Intraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases

Circulating tumor cells (CTC) have been studied extensively in various tumor types and are a well-established prognosticator in colorectal cancer (CRC). This is the first study to isolate CTC directly from the tumor outflow in secondary lung tumors. For this purpose in 24 patients with CRC who underwent pulmonary metastasectomy in curative intent blood was drawn intraoperatively...

Circulating DNA as biomarker in breast cancer

As the release of tumor-associated DNA into blood circulation is a common event in patients with cancer, screening of plasma or serum DNA may provide information on genetic and epigenetic profiles associated with breast cancer development, progression, and response to therapy. Quantitative testing of circulating DNA can reflect tumor burden, and molecular characterization of...

Breast cancer brain metastases: biology and new clinical perspectives

Because of improvements in the treatment of patients with metastatic breast cancer, the development of brain metastases (BM) has become a major limitation of life expectancy and quality of life for many breast cancer patients. The improvement of management strategies for BM is thus an important clinical challenge, especially among high-risk patients such as human epidermal growth...

Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients

Background The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progression might help to optimize treatment decisions. In this context, characterization of circulating tumor cells (CTCs) could be of relevance since metastatic tissue...

Improved Detection of Circulating Tumor Cells in Metastatic Colorectal Cancer by the Combination of the CellSearch® System and the AdnaTest®

Colorectal cancer (CRC) is one of the major causes of cancer-related death and reliable blood-based prognostic biomarkers are urgently needed. The enumeration and molecular characterization of circulating tumor cells (CTCs) has gained increasing interest in clinical practice. CTC detection by CellSearch® has already been correlated to an unfavorable outcome in metastatic CRC...

Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells

Background Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and metastatic relapse. Using expression profiling on early stage primary breast tumors, low IRX2 expression was previously shown to be associated with the presence of...

Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases

, Hamburg, GermanySabine Riethdorf, Stefan Werner, Simon A. Joosse, Klaus Pantel & Harriet WikmanDepartment of Trauma-, Hand- and Reconstructive Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg ... • Google Scholar Search for Klaus Pantel in:Nature Research journals • PubMed • Google Scholar Search for Harriet Wikman in:Nature Research journals • PubMed • Google Scholar Search for Sven O. Eicker

Catch and Release: rare cell analysis from a functionalised medical wire

Enumeration and especially molecular characterization of circulating tumour cells (CTCs) holds great promise for cancer management. We tested a modified type of an in vivo enrichment device (Catch&Release) for its ability to bind and detach cancer cells for the purpose of single-cell molecular downstream analysis in vitro. The evaluation showed that single–cell analysis using...

Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells

Pantel 0 Udo Schumacher Wolfgang Deppert 0 Florian Wegwitz 0 0 Institute for Tumor Biology, University Medical Center Hamburg-Eppendorf (UKE) , D-20246 Hamburg , Germany Background: Experimental analysis

Advances in circulating tumor cells (ACTC): from basic research to clinical practice

comparison studies between different methodologies for CTC isolation and detection were intensely discussed. In the opening plenary lecture, Klaus Pantel (UKE, Hamburg, Germany) pointed out that early changes

A Versatile Microarray Platform for Capturing Rare Cells

Technology. Author information Author notesMichael Hirtz, Anna Haller & Tobias M. Gorges These authors contributed equally to this work. Klaus Pantel & Harald Fuchs These authors jointly supervised this ... for Volkmar Müller in:Nature Research journals • PubMed • Google ScholarSearch for Klaus Pantel in:Nature Research journals • PubMed • Google ScholarSearch for Harald Fuchs in:Nature Research journals

Improved detection of circulating tumor cells in non-metastatic high-risk prostate cancer patients

Prues Martine Mazel Athina Markou Evi Lianidou Sven Peine Catherine Alix-Panabi?res Sabine Riethdorf Burkhard Beyer Thorsten Schlomm Klaus Pantel OPEN The relevance of blood-based assays to monitor ... the organisation ERA-NET on Translational Cancer Research (TRANSCAN) with the project title ?Circulating Tumor Cells as Biomarker for Minimal Residual Disease in Prostate Cancer?, CTC-SCAN (Klaus Pantel

Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein

Background As cancer-testis MAGE-A antigens are targets for tumor immunotherapy, it is important to study the regulation of their expression in cancers. This regulation appears to be rather complex and at the moment controversial. Although it is generally accepted that MAGE-A expression is controlled by epigenetics, the exact mechanisms of that control remain poorly understood...