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Search: authors:"Kramer, Barnett S"

13 papers found.
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Lung Cancer Risk and Demographic Characteristics of Current 20–29 Pack-Year Smokers: Implications for Screening

Based on current recommendations, 30+ pack-years of smoking are required for eligibility for low-dose CT (LDCT) lung cancer screening; former smokers must have quit within 15 years. We investigated whether current smokers with 20 to 29 pack-years have similar lung cancer risks as eligible former smokers and also whether they have a different demographic profile.

Surrogate Endpoint Analysis: An Exercise in Extrapolation

Surrogate endpoints offer the hope of smaller or shorter cancer trials. It is, however, important to realize they come at the cost of an unverifiable extrapolation that could lead to misleading conclusions. With cancer prevention, the focus is on hypothesis testing in small surrogate endpoint trials before deciding whether to proceed to a large prevention trial. However, it is...