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193 papers found.
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Predictable chronic mild stress promotes recovery from LPS-induced depression

Clinical depression is frequently comorbid with chronic inflammatory disease, and neuroinflammation is currently proposed as a key mechanism in major depressive disorders. Different from unpredictable chronic stress, which is a well-established animal model for depression, predictable chronic mild stress (PCMS), a routine stress experienced in day-to-day life, has been...

Nanosecond pulsed electric fields enhanced chondrogenic potential of mesenchymal stem cells via JNK/CREB-STAT3 signaling pathway

BackgroundNanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on short pulse duration and high field strength, such as effective cancer therapy. However, little is known about their effects on the differentiation of stem cells...

Global transcriptome analysis of H5N1 influenza virus-infected human cells

BackgroundInfluenza A virus (IAV) belongs to the Orthomyxoviridae family. IAV causes a highly contagious respiratory disease in humans that exacts severe economic losses globally. The virus uses strategies developed to exploit and subvert cellular proteins and pathways to increase its own replication and to inhibit antiviral immune response.ResultsA/bar-headed goose/Qinghai/1...

Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats

BackgroundApelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting its therapeutic benefit. The aim of this study is to create a new approach to treat type 2 diabetes by inducing prolonged expression of apelin in Wharton’s jelly...

Increasing Permeability of Coal Seam and Improving Gas Drainage Using a Liquid Carbon Dioxide Phase Transition Explosive Technology

. Authors’ Contributions Wenrui He performed the technological development and the program design and prepared and edited the manuscript. Fulian He revised and reviewed the manuscript. Kun Zhang, Yongqiang

Comparing Digital Phase-Locked Loop and Kalman Filter for Clock Tracking in Ultrawideband Location System

For timing and synchronization system, digital phase-locked loop (DPLL) and Kalman filter all have been widely used as the clock tracking and clock correction schemes for the similar structure and properties. This paper compares the two schemes used for ultrawideband (UWB) location system. The improved Kalman filter is more immune to interference.

Comparing Digital Phase-Locked Loop and Kalman Filter for Clock Tracking in Ultrawideband Location System

For timing and synchronization system, digital phase-locked loop (DPLL) and Kalman filter all have been widely used as the clock tracking and clock correction schemes for the similar structure and properties. This paper compares the two schemes used for ultrawideband (UWB) location system. The improved Kalman filter is more immune to interference.

Virtual Simulation Analysis of Rigid-Flexible Coupling Dynamics of Shearer with Clearance

A model for virtual simulation analysis of the rigid-flexible coupling of a shearer has been developed with the objective of addressing problems associated with lifetime mismatch and low reliability of pin rows of a scraper conveyor and the corresponding support mechanism of a shearer. Simulations were performed using the experimental roller load as stimulus. Results of the...

Virtual Simulation Analysis of Rigid-Flexible Coupling Dynamics of Shearer with Clearance

Street, Chaoyang District, Beijing City 100120, China Correspondence should be addressed to Kun Zhang; moc.361@gninoailnukgnahz Received 30 October 2017; Revised 4 February 2018; Accepted 20 February

Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population

Zhang. Data curation: Kun Zhang. Formal analysis: Kun Zhang. Project administration: Jun Zhang. Resources: Yangjun Zhu, Zhan Wang, Zijun Li. Writing ± original draft: Wei Huang. Writing ± review

Feasibility and transcriptomic analysis of betalain production by biomembrane surface fermentation of Penicillium novae-zelandiae

In this study, a biomembrane surface fermentation was used to produce red pigments of Penicillium novae-zelandiae, and the significant improvement in pigment production by the addition of 0.4 g/L of tyrosine demonstrated that the red pigments probably contained betalain. Therefore, one red pigment was purified, and identified as 2-decarboxybetanin by high-resolution mass...

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

Mesenchymal stem cells have been at the forefront of regenerative medicine for many years. Exosomes, which are nanovesicles involved in intercellular communication and the transportation of genetic material transportation that can be released by mesenchymal stem cells, have been recently reported to play a role in cell-free therapy of many diseases, including myocardial...

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

Mesenchymal stem cells have been at the forefront of regenerative medicine for many years. Exosomes, which are nanovesicles involved in intercellular communication and the transportation of genetic material transportation that can be released by mesenchymal stem cells, have been recently reported to play a role in cell-free therapy of many diseases, including myocardial...

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the...

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the...

Equivalent model optimization with cyclic correction approximation method considering parasitic effect for thermoelectric coolers

As thermoelectric coolers (TECs) have become highly integrated in high-heat-flux chips and high-power devices, the parasitic effect between component layers has become increasingly obvious. In this paper, a cyclic correction method for the TEC model is proposed using the equivalent parameters of the proposed simplified model, which were refined from the intrinsic parameters and...