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Control of the negative IRES trans-acting factor KHSRP by ubiquitination

Cells and viruses can utilize internal ribosome entry sites (IRES) to drive translation when cap-dependent translation is inhibited by stress or viral factors. IRES trans-acting factors (ITAFs) are known to participate in such cap-independent translation, but there are gaps in the understanding as to how ITAFs, particularly negative ITAFs, regulate IRES-driven translation. This...

Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach

information Author notes Ya-Ju Hsieh and Kun-Yi Chien contributed equally to this work. AffiliationsMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, TaiwanYa-Ju Hsieh ... , Kun-Yi Chien & Jau-Song YuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanKun-Yi Chien, I-Fang Yang, Chia-Chun Wu, Tung-Yung Huang & Jau-Song

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

• Google ScholarSearch for Xiao-min Wang in:Nature Research journals • PubMed • Google ScholarSearch for Kun-Yi Chien in:Nature Research journals • PubMed • Google ScholarSearch for Qiao Wu in:Nature

The Hsp90-Dependent Proteome Is Conserved and Enriched for Hub Proteins with High Levels of Protein–Protein Connectivity

Hsp90 is one of the most abundant and conserved proteins in the cell. Reduced levels or activity of Hsp90 causes defects in many cellular processes and also reveals genetic and nongenetic variation within a population. Despite information about Hsp90 protein–protein interactions, a global view of the Hsp90-regulated proteome in yeast is unavailable. To investigate the degree of...

Identification of the lamin A/C phosphoepitope recognized by the antibody P-STM in mitotic HeLa S3 cells

, Lang-Ming Chi, and Kun-Yi Chien performed mass spectrometry-based proteome analyses; Jeng-Ting Chen and Shih-Jie Lin carried out the immunoassays; Jau-Song Yu participated in study design and