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Dimeric structure of p300/CBP associated factor

Background p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones. However, relatively little is known about the regulation of the enzymatic activity of PCAF. Results Here we present two dimeric structures of the PCAF...

A Cytokine–Cytokine Interaction in the Assembly of Higher-Order Structure and Activation of the Interleukine-3:Receptor Complex

regions could enhance the specific activity of IL-3 significantly under physiological conditions (Kunmei Ji and Zhigang Liu, data not shown). Mutations on interface IV have also been shown to disrupt the