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Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

-Ying Chao,1 Yih-Ru Wu,1 Kuo-Hsuan Chang,1 Ming-Chung Lee,3 Guey-Jen Lee-Chen,2 and Chiung-Mei Chen1 1Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine ... and Kuo-Hsuan Chang commented on the experiment design. Ming-Chung Lee provided CHM materials for this study. All authors approved the final version of the manuscript. I-Cheng Chen and Te-Hsien Lin

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Alzheimer’s disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation of tau, is the most common cause of dementia among older people. Generation of patient-specific neurons by induced pluripotent stem cell (iPSC) technology facilitates exploration of the disease features in live human neurons from AD patients. In this study, we...

Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

/ 11 Author Contributions Conceptualization: Yu-hua Huang, Yi-Chun Chen. Data curation: Chiung-Mei Chen, Kuo-Hsuan Chang, Huei-Wen Chen. Formal analysis: Yu-hua Huang, Huei-Wen Chen. Methodology ... : Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang. Project administration: Yi-Chun Chen. Supervision: Yi-Chun Chen. Writing ± original draft: Yu-hua Huang. Writing ± review & editing: Yi-Chun Chen. 9

A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy

authors declare no conflicts of interests. Author Contributions Conceptualization: Jung-Lung Hsu, Hui-Ching Hsu, Yi-Ching Weng, Ai-Lun Lo, Kuo Hsuan Chang, Hong-Shiu Chang, Hung-Chou Kuo, Chin-Chang ... Huang, Long-Sun Ro. Data curation: Ming-Feng Liao. Funding acquisition: Long-Sun Ro. Investigation: Ming-Feng Liao, Hui-Ching Hsu, Yi-Ching Weng, Ai-Lun Lo, Kuo-Hsuan Chang, Hong-Shiu Chang, Hung-Chou

Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome

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Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous deep intracerebral hemorrhage (SDICH) is a devastating stroke subtype. The causes of SDICH are heterogeneous. Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the development of aneurysm and may increase risks of intracerebral hemorrhage. MMP activities are modulated by their endogenous inhibitors, tissue inhibitors...

Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients

Background Huntington's disease (HD) is caused by expanded CAG repeats encoding a polyglutamine tract in the huntingtin (HTT) protein. A number of differentially-expressed protein molecules have been identified in striatum of HD animal models. Here we examined if the expression changes could be visualized in the peripheral leukocytes of HD patients and pre-symptomatic HD (PreHD...

Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

Background Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the central nervous system with different pathogenesis, brain lesion patterns, and treatment strategies. However, it is still difficult to distinguish these two disease entities by neuroimaging studies. Herein, we attempt to differentiate NMOSD from MS by comparing...

Clinical Correlations of Motor and Somatosensory Evoked Potentials in Neuromyelitis Optica

Background Motor and somatosensory evoked potentials (MEPs and SSEPs) are sensitive tools for detecting subclinical lesions, assessing disease severity, and determining the prognosis for outcomes of patients with inflammatory neurological diseases such as multiple sclerosis. However, their roles in neuromyelitis optica (NMO), a severe inflammatory neurological disease that...

Painful ophthalmoplegia with normal cranial imaging

Background Painful ophthalmoplegia with normal cranial imaging is rare and confined to limited etiologies. In this study, we aimed to elucidate these causes by evaluating clinical presentations and treatment responses. Methods Cases of painful ophthalmoplegia with normal cranial MRI at a single center between January 2001 and June 2011 were retrospectively reviewed. Diagnoses of...

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population

A single nucleotide polymorphism GRN rs5848 (3′UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson’s disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold...

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3

 Ventura Copyright © 2013 Kuo-Hsuan Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3

 Ventura Copyright © 2013 Kuo-Hsuan Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Genetic Variants of LRRK2 in Taiwanese Parkinson’s Disease

Genetic variants of leucine-rich repeat kinase 2 (LRRK2) were reported to alter the risk for Parkinson’s disease (PD). However, the genetic spectrum of LRRK2 variants has not been clearly disclosed yet in Taiwanese population. Herein, we sequenced LRRK2 coding region in 70 Taiwanese early onset PD patients (age at onset ≤ 50), and found six amino acid-changing single nucleotide...

Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome

Background The underlying change of gene network expression of Guillain-Barré syndrome (GBS) remains elusive. We sought to identify GBS-associated gene networks and signaling pathways by analyzing the transcriptional profile of leukocytes in the patients with GBS. Methods and Findings Quantitative global gene expression microarray analysis of peripheral blood leukocytes was...