Advanced search    

Search: authors:"Lara M Mangravite"

11 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

Alzheimer’s disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and...

Integrative Modeling of eQTLs and Cis-Regulatory Elements Suggests Mechanisms Underlying Cell Type Specificity of eQTLs

Genetic variants in cis-regulatory elements or trans-acting regulators frequently influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL) mapping has paralleled the adoption of genome-wide association studies (GWAS) for the analysis of complex traits and disease in humans. Under the hypothesis...

A community approach to mortality prediction in sepsis via gene expression analysis

Ephraim L. Tsalik 12 13 Lara M. Mangravite 6 7 15 0 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, MA 02142 USA 1 Marie Bashir Institute for Infectious Diseases

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Lara M. Mangravite 4 Mette A. Peters 4 Jessica D. Tenenbaum 5 J. Will Thompson 6 Rima Kaddurah-Daouk 0 0 Department of Psychiatry and Behavioral Sciences, and the Duke Institute for Brain Sciences, Duke

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism

3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway and is inhibited by statins, a class of cholesterol-lowering drugs. Expression of an alternatively spliced HMGCR transcript lacking exon 13, HMGCR13(−), has been implicated in the variation of plasma LDL-cholesterol (LDL-C) and is the single most...

RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin

Although statin drugs are generally efficacious for lowering plasma LDL-cholesterol levels, there is considerable variability in response. To identify candidate genes that may contribute to this variation, we used an unbiased genome-wide filter approach that was applied to 10,149 genes expressed in immortalized lymphoblastoid cell lines (LCLs) derived from 480 participants of the...

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that...

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

Background Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs) contributing to this variation, we performed a combined analysis of genome-wide association (GWA) results from three trials of statin efficacy. Methods and Principal Findings Bayesian and standard...

Prediction of human population responses to toxic compounds by a collaborative competition

), RWTH Aachen University, Aachen, Germany. Federica Eduati, Lara M Mangravite, Tao Wang & Hao Tang These authors contributed equally to this work. AffiliationsEuropean Molecular Biology Laboratory ... , Chinese Academy of Sciences, Beijing, China.Shihua Zhang & Junfei ZhaoConsortiaThe NIEHS-NCATS-UNC DREAM Toxicogenetics CollaborationFederica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

Oliva , Yuanfang Guan and Lara M. Mangravite in the author list. This has now been corrected in the HTML; the PDF version of the paper was correct from the time of publication 12 Gopalacharyulu, Mohsen

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

K. Gregersen, Stephen Friend, Robert Plenge, Gustavo Stolovitzky, Baldo Oliva, Yuanfang Guan and Lara M. Mangravite in the author list. This has now been corrected in the HTML; the PDF version of the ... , Baldo Oliva, Yuanfang Guan & Lara M. Mangravite These authors contributed equally to this work AffiliationsSage Bionetworks, Seattle, Washington 98115, USASolveig K. Sieberts, Abhishek Pratap, Christine