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Search: authors:"Lars Leidolt"

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Focal T2 and FLAIR hyperintensities within the infarcted area: A suitable marker for patient selection for treatment?

P. Klinger-Gratz, Lars Leidolt, Matthias F. Lang, Gerhard Schroth, Pasquale Mordasini, Mirjam R. Heldner, Marie-Luise Mono, Rebekka Kurmann, Monika Buehlmann, Urs Fischer, Marcel Arnold, Jan Gralla ... , Heinrich P. Mattle, Marwan El-Koussy, Simon Jung. Marwan El-Koussy, Simon Jung. Formal analysis: Julia Meisterernst, Pascal P. Klinger-Gratz, Lars Leidolt, Heinrich P. Mattle, Investigation: Urs Fischer

Significant Artifact Reduction at 1.5T and 3T MRI by the Use of a Cochlear Implant with Removable Magnet: An Experimental Human Cadaver Study

Objective Cochlear implants (CIs) are standard treatment for postlingually deafened individuals and prelingually deafened children. This human cadaver study evaluated diagnostic usefulness, image quality and artifacts in 1.5T and 3T magnetic resonance (MR) brain scans after CI with a removable magnet. Methods Three criteria (diagnostic usefulness, image quality, artifacts) were...

Optimal Dose Levels in Screening Chest CT for Unimpaired Detection and Volumetry of Lung Nodules, with and without Computer Assisted Detection at Minimal Patient Radiation

Objectives The aim of this phantom study was to minimize the radiation dose by finding the best combination of low tube current and low voltage that would result in accurate volume measurements when compared to standard CT imaging without significantly decreasing the sensitivity of detecting lung nodules both with and without the assistance of CAD. Methods An anthropomorphic...

Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

Background Deletions of the mitochondrial DNA (mtDNA) accumulate to high levels in dopaminergic neurons of the substantia nigra pars compacta (SNc) in normal aging and in patients with Parkinson's disease (PD). Human nigral neurons characteristically contain the pigment neuromelanin (NM), which is believed to alter the cellular redox-status. The impact of neuronal pigmentation...