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Incident Detection of High-Risk Human Papillomavirus Infections in a Cohort of High-Risk Women Aged 25–65 Years

Background. The risk of incident high-risk human papillomavirus (HR-HPV) infection associated with recent sexual behaviors is undefined in mid-adult women (defined as women aged 25–65 years). Methods. Triannually, 420 female online daters aged 25–65 years submitted vaginal specimens for HPV testing and completed health and sexual behavior questionnaires. The cumulative incidence...

High Rates of Incident and Prevalent Anal Human Papillomavirus Infection Among Young Men Who Have Sex With Men

Background. There are few published estimates of anal human papillomavirus (HPV) infection rates among young men who have sex with men (YMSM). Methods. We estimated incidence and prevalence of type-specific anal HPV infection using clinician-collected anal swabs for HPV DNA testing obtained during a 1-year prospective study of 94 YMSM (mean age, 21 years) in Seattle. Results...

Response: Re: Human Papillomavirus Type 16 and 18 Variants: Race-Related Distribution and Persistence

haplotypes may be associated with inadequate immune presentation of epitopes encoded by particular HPV variants, thereby affecting their capacity to become established or to replicate. LONG FU XI LAURA A ... . KOUTSKY The work was supported by Public Health Service grant CA 84396 to L. F. Xi. Dr Koutsky is currently conducting research sponsored by Merck. The study protocol was approved by the institutional

Serum Antibody Response Following Genital α9 Human Papillomavirus Infection in Young Men

Background. Although the prevalence of human papillomavirus (HPV) genital infection is similarly high in males and females, seroprevalence is lower in males. This study assessed rates and determinants of seroconversion after detection of genital HPV infection in young men. Methods. We investigated HPV type-specific seroconversion in a cohort of heterosexual male university...

Inverse Association between Methylation of Human Papillomavirus Type 16 DNA and Risk of Cervical Intraepithelial Neoplasia Grades 2 or 3

Background The clinical relevance of human papillomavirus type 16 (HPV16) DNA methylation has not been well documented, although its role in modulation of viral transcription is recognized. Methods Study subjects were 211 women attending Planned Parenthood clinics in Western Washington for routine Papanicolaou screening who were HPV16 positive at the screening and/or subsequent...

Human Papillomavirus Type 16 Variants in Paired Enrollment and Follow-up Cervical Samples: Implications for a Proper Understanding of Type-Specific Persistent Infections

Prospective studies of the persistence of human papilloma-virus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant...

Re: Specific Antibody Levels at the Cervix During the Menstrual Cycle of Women Vaccinated With Human Papillomavirus 16 Virus-Like Particles

vaccine efficacy, it will be important to assess the duration of HPV16 L1 VLP vaccine efficacy over a longer period of follow-up. ELIAV BARR LAURA A. KOUTSKY REFERENCES NOTES Editors note: E. Barr is an

Comparison of Incident Cervical and Vulvar/Vaginal Human Papillomavirus Infections in Newly Sexually Active Young Women

Rachel L. Winer James P. Hughes Qinghua Feng 0 Sandra O'Reilly Nancy B. Kiviat 0 Laura A. Koutsky 0 Pathology, University of Washington , Seattle Vulvar/vaginal human papillomavirus (HPV) infections

Development of Genital Warts after Incident Detection of Human Papillomavirus Infection in Young Men

Determining the rate at which men develop genital warts after infection with alpha genus human papillomavirus (HPV) types will provide important information for the design of prevention strategies. We conducted a cohort study of 18–21-year-old men who underwent triannual genital examinations. The 24-month cumulative genital wart incidence was 57.9% (95% confidence interval [CI...

Viral Load in the Natural History of Human Papillomavirus Type 16 Infection: A Nested Case–Control Study

Background. Viral load may influence the course of human papillomavirus type 16 (HPV-16) infection. Methods. This case-control study was nested within the 2-year Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study, in which women were followed semiannually for HPV and cervical intraepithelial neoplasia (CIN). Case...

Human Papillomavirus (HPV) Type 16 and Type 18 DNA Loads at Baseline and Persistence of Type-Specific Infection during a 2-Year Follow-Up

BackgroundStudies of viral load–associated persistence of human papillomavirus (HPV) infection are rare, with inconsistent results reported MethodsThe study subjects were 741 and 289 women who were positive for HPV type 16 (HPV-16) and HPV type 18 (HPV-18), respectively, at the time of enrollment into in the ASCUS-LSIL (Atypical Squamous Cells of Undetermined Significance–Low...

Effect of Cervical Cytologic Status on the Association between Human Papillomavirus Type 16 DNA Load and the Risk of Cervical Intraepithelial Neoplasia Grade 3

Background. Although correlations between cervical cytologic status and both human papillomavirus (HPV) load and histopathologic status are recognized, it is largely undetermined whether the association between the HPV DNA load and the risk of cervical intraepithelial neoplasia grade 3 (CIN-3) differs on the basis of cervical cytologic findings. Methods. Study subjects were 821...

Antibody Responses in Oral Fluid after Administration of Prophylactic Human Papillomavirus Vaccines

We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference...

Risk of Female Human Papillomavirus Acquisition Associated with First Male Sex Partner

Rachel L. Winer Qinghua Feng James P. Hughes 0 Sandra O'Reilly Nancy B. Kiviat Laura A. Koutsky 0 Biostatistics, University of Washington , Seattle - To quantify the risk of human papillomavirus

Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 after Loop Electrosurgical Excision Procedure Associated with Human Papillomavirus Type 16 Variants

Identification of factors associated with risk of relapse after treatment for high-grade cervical intraepithelial neoplasia (CIN) has important clinical implications. Study subjects were women participating in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study who were treated for CIN3 by loop electrosurgical...

Influence of Loop Electrosurgical Excision Procedure on Subsequent Acquisition of New Human Papillomavirus Infections

BackgroundThe impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described MethodsThe acquisition of new HPV infections was compared in HPV-positive women who underwent colposcopy and were treated by LEEP (n = 195) and those who were untreated (n...

Persistence of Genital Human Papillomavirus Infection in a Long-Term Follow-Up Study of Female University Students

Background. Little is known about the epidemiology of human papillomavirus (HPV) infections that persist for more than a few years. Methods. Four to 12 years after participation in a longitudinal study of incident HPV infection, a cohort of former university students returned for a follow-up visit that included HPV genotyping of cervical and vulvovaginal swab specimens and...

Human Papillomavirus Type 16 and 18 Variants: Race-Related Distribution and Persistence

Background: Analogous to the geographic distribution of variants of human papillomavirus (HPV) types, the distribution and persistence of these variants among infected individuals may be related to the racial composition of a population living in one geographic region. Methods: We studied 1114 women in the United States participating in the Atypical Squamous Cells of Undetermined...