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Pain Clinic in Tibet, China: A Single-Center Retrospective Study

Copyright © 2019 Le Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... during the current study are available from the corresponding author on reasonable request. Conflicts of Interest The authors declare that they have no conflicts of interest. Authors’ Contributions Both Le

Pain Clinic in Tibet, China: A Single-Center Retrospective Study

Copyright © 2019 Le Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... during the current study are available from the corresponding author on reasonable request. Conflicts of Interest The authors declare that they have no conflicts of interest. Authors’ Contributions Both Le

Risk factors for prolonged hypotension in patients with pheochromocytoma undergoing laparoscopic adrenalectomy: a single-center retrospective study

, P.R. ChinaShubin Wu, Weiyun Chen, Le Shen, Li Xu, Afang Zhu & Yuguang Huang AuthorsSearch for Shubin Wu in:Nature Research journals • PubMed • Google Scholar Search for Weiyun Chen in:Nature Research ... journals • PubMed • Google Scholar Search for Le Shen in:Nature Research journals • PubMed • Google Scholar Search for Li Xu in:Nature Research journals • PubMed • Google Scholar Search for Afang Zhu

Risk factors of post-operative severe hyperlactatemia and lactic acidosis following laparoscopic resection for pheochromocytoma

AffiliationsDepartment of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, P.R. ChinaShubin Wu, Weiyun Chen, Le Shen, Li Xu ... , Afang Zhu & Yuguang Huang AuthorsSearch for Shubin Wu in:Nature Research journals • PubMed • Google Scholar Search for Weiyun Chen in:Nature Research journals • PubMed • Google Scholar Search for Le

Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy

clinically significant. Acknowledgments We thank Prof. Yong He and Dr. Zhijiang Wang for their assistance in the research design and data analysis. Author Contributions Data curation: Tangmi Yuan, Le Shen ... , Yuguang Huang. Formal analysis: Tao Wang, Naishi Li, Hui You, Tixian Xiao. Project administration: Feng Feng, Chao Ma. Resources: Peiyao Liu, Le Shen, Yuguang Huang. Writing ± original draft: Juan Li

Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1

The pathogenesis of diabetic neuropathic pain is complicated and its underlying mechanisms remain unclear. Calmodulin-dependent protein kinases (CaMKs) IV (CaMKIV), one of CaMKs, regulates several transcription factors in pain mechanisms. High-mobility group box 1 (HMGB1) is a key mediator in diabetic neuropathic pain. This study aims to find the roles and mechanisms of CaMIV in...

Claudin-2-dependent paracellular channels are dynamically gated

Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured. We report a novel trans-tight junction patch clamp technique that detects flux across individual claudin-2 channels within the tight...

Prior Image Guided Undersampled Dual Energy Reconstruction with Piecewise Polynomial Function Constraint

Dual energy CT has the ability to give more information about the test object by reconstructing the attenuation factors under different energies. These images under different energies share identical structures but different attenuation factors. By referring to the fully sampled low-energy image, we show that it is possible to greatly reduce the sampling rate of the high-energy...

Prior Image Guided Undersampled Dual Energy Reconstruction with Piecewise Polynomial Function Constraint

Dual energy CT has the ability to give more information about the test object by reconstructing the attenuation factors under different energies. These images under different energies share identical structures but different attenuation factors. By referring to the fully sampled low-energy image, we show that it is possible to greatly reduce the sampling rate of the high-energy...

Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol

Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis. Treatment with statins, inhibitors of cholesterol synthesis, activates intestinal SREBP2, which may hinder their cholesterol-lowering effects. Overactivation of SREBP2 in mouse liver was shown to have no effect on plasma cholesterol. However, the influence of...

A porous defense: the leaky epithelial barrier in intestinal disease

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. This intestinal barrier is compromised in a number of intestinal diseases, most notably inflammatory bowel disease. In vitro studies have demonstrated that cytokines elaborated by immune cells can cause the mucosal barrier to become leaky; these cytokines are...